Tumor Necrosis Factor-α Mediates Osteopenia Caused by Depletion of Antioxidants

We recently found that estrogen deficiency leads to a lowering of thiol antioxidant defenses in rodent bone. Moreover, administration of agents that increase the concentration in bone of glutathione, the main intracellular antioxidant, prevented estrogen-deficiency bone loss, whereas depletion of gl...

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Veröffentlicht in:	Endocrinology (Philadelphia) 2005-01, Vol.146 (1), p.113-118
Hauptverfasser:	Jagger, C. J, Lean, J. M, Davies, J. T, Chambers, T. J
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antimetabolites - pharmacology Antioxidants Antioxidants - metabolism Biological and medical sciences Bone Diseases, Metabolic - chemically induced Bone Diseases, Metabolic - etiology Bone Diseases, Metabolic - prevention & control Bone growth Bone loss Bone Resorption Buthionine sulfoximine Buthionine Sulfoximine - pharmacology Depletion Diseases of the osteoarticular system Estrogens Estrogens - deficiency Fundamental and applied biological sciences. Psychology Gene expression Glutathione Glutathione - deficiency Intracellular signalling Medical sciences Mice Mice, Inbred Strains Mice, Knockout Oophorectomy Osteogenesis Osteopenia Osteoporosis. Osteomalacia. Paget disease Ovariectomy Reactive oxygen species Receptors Receptors, Tumor Necrosis Factor - chemistry Receptors, Tumor Necrosis Factor - metabolism Signal Transduction Solubility Sulfhydryl Compounds - antagonists & inhibitors Tumor Necrosis Factor-alpha - metabolism Tumor necrosis factor-α Vertebrates: endocrinology
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