Characterization of Novel Inhibitors of Cyclin-Dependent Kinases

In epithelial cells progression through the G1 phase of the cell cycle and preparing the cell for the S phase is regulated by cyclin D1-cdk4. Cells that express the retinoblastoma protein (pRb) are dependent on cyclin D1-cdk4 activity for their proliferation while cells that do not express pRb are n...

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Veröffentlicht in:	Biochemical and biophysical research communications 1999-07, Vol.260 (3), p.768-774
Hauptverfasser:	Kent, Lorraine L., Hull-Campbell, Nicolina E., Lau, Ted, Wu, John C., Thompson, Stewart A., Nori, Mukund
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine Triphosphate - metabolism anticancer agents Antineoplastic Agents - chemistry Antineoplastic Agents - pharmacology Antineoplastic Agents - therapeutic use Benzoic Acid - chemistry Benzoic Acid - pharmacology Benzoic Acid - therapeutic use Blotting, Western Breast Neoplasms - drug therapy Breast Neoplasms - enzymology Breast Neoplasms - metabolism Breast Neoplasms - pathology Cdk4 Cell Division - drug effects Cyclin D1 - antagonists & inhibitors Cyclin D1 - metabolism Cyclin-Dependent Kinase 4 Cyclin-Dependent Kinases - antagonists & inhibitors Cyclin-Dependent Kinases - isolation & purification Cyclin-Dependent Kinases - metabolism Drug Screening Assays, Antitumor Enzyme Inhibitors - chemistry Enzyme Inhibitors - pharmacology Enzyme Inhibitors - therapeutic use Humans Indoles - chemistry Indoles - pharmacology Indoles - therapeutic use inhibitors Inhibitory Concentration 50 Kinetics novel pRb Proto-Oncogene Proteins Retinoblastoma Protein - genetics Retinoblastoma Protein - metabolism Substrate Specificity Tumor Cells, Cultured Urea - chemistry Urea - pharmacology Urea - therapeutic use
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