Curcumin loaded and protective system based on complex of κ-carrageenan and lysozyme
A facile approach to fabricate micro-complex in moderate condition via self-assembly of κ-carrageenan (CRG) and lysozyme (Lys) was investigated for the first time to encapsulate and protect curcumin. The interaction between CRG and Lys, size and morphology were studied by zeta potential, UV–vis spec...
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| Veröffentlicht in: | Food research international 2014-05, Vol.59, p.61-66 |
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| creator | Xu, Wei Jin, Weiping Zhang, Chunlan Li, Zhenshun Lin, Liufeng Huang, Qing Ye, Shuxin Li, Bin |
| description | A facile approach to fabricate micro-complex in moderate condition via self-assembly of κ-carrageenan (CRG) and lysozyme (Lys) was investigated for the first time to encapsulate and protect curcumin. The interaction between CRG and Lys, size and morphology were studied by zeta potential, UV–vis spectroscopy, circular dichroism (CD), scanning electron microscope (SEM), transmission electron microscopy (TEM) and X-ray photoelectron spectroscopy (XPS). A tentative interactive model was proposed for polysaccharide and protein. The results indicated that the spherical shaped CRG/Lys complex with 1μm diameter was spontaneously formed by one spot incubating. Both CRG and Lys were participated in forming the shell of micro-complex synthesized through physical interactions. The encapsulation efficiency (EE) and loading capacity (LC) of curcumin for the CRG/Lys complex prepared with CRG/Lys ratio 2:1 were 71±0.02% and 50.71±0.71μgml−1 respectively. The stability of curcumin loaded in complex was improved about 2.7fold, 2fold and 1.7fold when disposed with 80°C treatment for 1min, 60°C treatment for 30min and ultraviolet radiation for 2h. DPPH measurement verified the protection of bioactivity as encapsulated. The worthwhile endeavor elucidated proteins/polysaccharides complex was feasible to solubilize and protect sensitive amphiphilic bioactive compounds and has extensive potential in food and medicinal application with various purposes.
•CRG/Lys complex was spontaneously formed by one spot incubating.•A tentative interactive model was proposed for CRG/Lys complex formation.•The stability and bioactive of curcumin loaded was significantly improved. |
| doi_str_mv | 10.1016/j.foodres.2014.01.059 |
| format | Article |
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•CRG/Lys complex was spontaneously formed by one spot incubating.•A tentative interactive model was proposed for CRG/Lys complex formation.•The stability and bioactive of curcumin loaded was significantly improved.</description><identifier>ISSN: 0963-9969</identifier><identifier>EISSN: 1873-7145</identifier><identifier>DOI: 10.1016/j.foodres.2014.01.059</identifier><language>eng</language><publisher>Kidlington: Elsevier Ltd</publisher><subject>Biological and medical sciences ; Curcumin ; Dichroism ; Encapsulation ; Food industries ; Foods ; Fundamental and applied biological sciences. Psychology ; Lysozyme ; Polysaccharides ; Protection ; Proteins ; Scanning electron microscopy ; Self assembly ; Stability ; κ-Carrageenan</subject><ispartof>Food research international, 2014-05, Vol.59, p.61-66</ispartof><rights>2014 Elsevier Ltd</rights><rights>2015 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c405t-7a3a032b8d81d581ea321471dc3fd3dc3f6332358b9331b5c6fe40108da66c543</citedby><cites>FETCH-LOGICAL-c405t-7a3a032b8d81d581ea321471dc3fd3dc3f6332358b9331b5c6fe40108da66c543</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.foodres.2014.01.059$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=28399393$$DView record in Pascal Francis$$Hfree_for_read</backlink></links><search><creatorcontrib>Xu, Wei</creatorcontrib><creatorcontrib>Jin, Weiping</creatorcontrib><creatorcontrib>Zhang, Chunlan</creatorcontrib><creatorcontrib>Li, Zhenshun</creatorcontrib><creatorcontrib>Lin, Liufeng</creatorcontrib><creatorcontrib>Huang, Qing</creatorcontrib><creatorcontrib>Ye, Shuxin</creatorcontrib><creatorcontrib>Li, Bin</creatorcontrib><title>Curcumin loaded and protective system based on complex of κ-carrageenan and lysozyme</title><title>Food research international</title><description>A facile approach to fabricate micro-complex in moderate condition via self-assembly of κ-carrageenan (CRG) and lysozyme (Lys) was investigated for the first time to encapsulate and protect curcumin. The interaction between CRG and Lys, size and morphology were studied by zeta potential, UV–vis spectroscopy, circular dichroism (CD), scanning electron microscope (SEM), transmission electron microscopy (TEM) and X-ray photoelectron spectroscopy (XPS). A tentative interactive model was proposed for polysaccharide and protein. The results indicated that the spherical shaped CRG/Lys complex with 1μm diameter was spontaneously formed by one spot incubating. Both CRG and Lys were participated in forming the shell of micro-complex synthesized through physical interactions. The encapsulation efficiency (EE) and loading capacity (LC) of curcumin for the CRG/Lys complex prepared with CRG/Lys ratio 2:1 were 71±0.02% and 50.71±0.71μgml−1 respectively. The stability of curcumin loaded in complex was improved about 2.7fold, 2fold and 1.7fold when disposed with 80°C treatment for 1min, 60°C treatment for 30min and ultraviolet radiation for 2h. DPPH measurement verified the protection of bioactivity as encapsulated. The worthwhile endeavor elucidated proteins/polysaccharides complex was feasible to solubilize and protect sensitive amphiphilic bioactive compounds and has extensive potential in food and medicinal application with various purposes.
•CRG/Lys complex was spontaneously formed by one spot incubating.•A tentative interactive model was proposed for CRG/Lys complex formation.•The stability and bioactive of curcumin loaded was significantly improved.</description><subject>Biological and medical sciences</subject><subject>Curcumin</subject><subject>Dichroism</subject><subject>Encapsulation</subject><subject>Food industries</subject><subject>Foods</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Lysozyme</subject><subject>Polysaccharides</subject><subject>Protection</subject><subject>Proteins</subject><subject>Scanning electron microscopy</subject><subject>Self assembly</subject><subject>Stability</subject><subject>κ-Carrageenan</subject><issn>0963-9969</issn><issn>1873-7145</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><recordid>eNqFkM9u1DAQxi1UJLZbHgEpFyQuSWcycRKfEFpRQKrEhZ4trz1BXiXxYmcrlkfrQ_BMeNlVr53DzGG-b_78hHiHUCFge7urhhBc5FTVgE0FWIFUr8QK-47KDht5JVagWiqVatUbcZ3SDgBa2amVeNgcoj1Mfi7GYBy7wsyu2MewsF38IxfpmBaeiq1JuRfmwoZpP_LvIgzF36fSmhjNT-bZzP-N4zGFP8eJb8TrwYyJ317qWjzcff6x-Vref__ybfPpvrQNyKXsDBmgetu7Hp3skQ3V2HToLA2OTrklqkn2W0WEW2nbgRtA6J1pWysbWosP57n54l8HTouefLI8jmbmcEgaOwLMAd3LUkkZpgTVZ6k8S20MKUUe9D76ycSjRtAn4nqnL8T1ibgG1Jl49r2_rDDJmnGIZrY-PZvrnpSi_MlafDzrOKN59Bx1sp5ny87HjF274F_Y9A-zKZnl</recordid><startdate>20140501</startdate><enddate>20140501</enddate><creator>Xu, Wei</creator><creator>Jin, Weiping</creator><creator>Zhang, Chunlan</creator><creator>Li, Zhenshun</creator><creator>Lin, Liufeng</creator><creator>Huang, Qing</creator><creator>Ye, Shuxin</creator><creator>Li, Bin</creator><general>Elsevier Ltd</general><general>Elsevier</general><scope>IQODW</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>8FD</scope><scope>F28</scope><scope>FR3</scope></search><sort><creationdate>20140501</creationdate><title>Curcumin loaded and protective system based on complex of κ-carrageenan and lysozyme</title><author>Xu, Wei ; Jin, Weiping ; Zhang, Chunlan ; Li, Zhenshun ; Lin, Liufeng ; Huang, Qing ; Ye, Shuxin ; Li, Bin</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c405t-7a3a032b8d81d581ea321471dc3fd3dc3f6332358b9331b5c6fe40108da66c543</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Biological and medical sciences</topic><topic>Curcumin</topic><topic>Dichroism</topic><topic>Encapsulation</topic><topic>Food industries</topic><topic>Foods</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Lysozyme</topic><topic>Polysaccharides</topic><topic>Protection</topic><topic>Proteins</topic><topic>Scanning electron microscopy</topic><topic>Self assembly</topic><topic>Stability</topic><topic>κ-Carrageenan</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Xu, Wei</creatorcontrib><creatorcontrib>Jin, Weiping</creatorcontrib><creatorcontrib>Zhang, Chunlan</creatorcontrib><creatorcontrib>Li, Zhenshun</creatorcontrib><creatorcontrib>Lin, Liufeng</creatorcontrib><creatorcontrib>Huang, Qing</creatorcontrib><creatorcontrib>Ye, Shuxin</creatorcontrib><creatorcontrib>Li, Bin</creatorcontrib><collection>Pascal-Francis</collection><collection>CrossRef</collection><collection>Technology Research Database</collection><collection>ANTE: Abstracts in New Technology & Engineering</collection><collection>Engineering Research Database</collection><jtitle>Food research international</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Xu, Wei</au><au>Jin, Weiping</au><au>Zhang, Chunlan</au><au>Li, Zhenshun</au><au>Lin, Liufeng</au><au>Huang, Qing</au><au>Ye, Shuxin</au><au>Li, Bin</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Curcumin loaded and protective system based on complex of κ-carrageenan and lysozyme</atitle><jtitle>Food research international</jtitle><date>2014-05-01</date><risdate>2014</risdate><volume>59</volume><spage>61</spage><epage>66</epage><pages>61-66</pages><issn>0963-9969</issn><eissn>1873-7145</eissn><abstract>A facile approach to fabricate micro-complex in moderate condition via self-assembly of κ-carrageenan (CRG) and lysozyme (Lys) was investigated for the first time to encapsulate and protect curcumin. The interaction between CRG and Lys, size and morphology were studied by zeta potential, UV–vis spectroscopy, circular dichroism (CD), scanning electron microscope (SEM), transmission electron microscopy (TEM) and X-ray photoelectron spectroscopy (XPS). A tentative interactive model was proposed for polysaccharide and protein. The results indicated that the spherical shaped CRG/Lys complex with 1μm diameter was spontaneously formed by one spot incubating. Both CRG and Lys were participated in forming the shell of micro-complex synthesized through physical interactions. The encapsulation efficiency (EE) and loading capacity (LC) of curcumin for the CRG/Lys complex prepared with CRG/Lys ratio 2:1 were 71±0.02% and 50.71±0.71μgml−1 respectively. The stability of curcumin loaded in complex was improved about 2.7fold, 2fold and 1.7fold when disposed with 80°C treatment for 1min, 60°C treatment for 30min and ultraviolet radiation for 2h. DPPH measurement verified the protection of bioactivity as encapsulated. The worthwhile endeavor elucidated proteins/polysaccharides complex was feasible to solubilize and protect sensitive amphiphilic bioactive compounds and has extensive potential in food and medicinal application with various purposes.
•CRG/Lys complex was spontaneously formed by one spot incubating.•A tentative interactive model was proposed for CRG/Lys complex formation.•The stability and bioactive of curcumin loaded was significantly improved.</abstract><cop>Kidlington</cop><pub>Elsevier Ltd</pub><doi>10.1016/j.foodres.2014.01.059</doi><tpages>6</tpages></addata></record> |
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| subjects | Biological and medical sciences Curcumin Dichroism Encapsulation Food industries Foods Fundamental and applied biological sciences. Psychology Lysozyme Polysaccharides Protection Proteins Scanning electron microscopy Self assembly Stability κ-Carrageenan |
| title | Curcumin loaded and protective system based on complex of κ-carrageenan and lysozyme |
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