Enzyme-catalysed regio- and enantioselective preparative scale synthesis of (S)-2-hydroxy alkanones

α-Hydroxy alkanones were synthesised with high enantiomeric purity by stereoselective enzyme-catalysed diketone reduction. Both diketone reduction and cofactor regeneration were accomplished with purified carbonyl reductase from Candida parapsilosis (CPCR2). The reaction products were isolated by co...

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Veröffentlicht in:	RSC advances 2015-01, Vol.5 (48), p.38271-38276
Hauptverfasser:	Loderer, C., Ansorge-Schumacher, M. B.
Format:	Artikel
Sprache:	eng
Schlagworte:	Aliphatic compounds Biotransformation Candida Column chromatography Diketones Optical properties Optical rotation Reduction
Online-Zugang:	Volltext
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