Diastereoselective synthesis of substituted diaziridines from simple ketones and aldehydes

Diastereoselective synthesis of substituted diaziridines from simple ketones and aldehydes

Diastereopure substituted diaziridines from simple ketones, aldehydes and amines are here reported. These important chemical scaffolds are obtained in the presence of a weak inorganic base and hydroxylamine O-sulfonic acid (HOSA). This method introduces three stereocenters in one step to provide a w...

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Veröffentlicht in:Chemical communications (Cambridge, England) England), 2015-09, Vol.51 (70), p.13511-13514
Hauptverfasser: Beebe, Alexander W, Dohmeier, Emma F, Moura-Letts, Gustavo
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Sprache:eng
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Aldehydes
Amines
Hydroxides
Ketones
Scaffolds
Synthesis
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container_title Chemical communications (Cambridge, England)
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creator Beebe, Alexander W
Dohmeier, Emma F
Moura-Letts, Gustavo
description Diastereopure substituted diaziridines from simple ketones, aldehydes and amines are here reported. These important chemical scaffolds are obtained in the presence of a weak inorganic base and hydroxylamine O-sulfonic acid (HOSA). This method introduces three stereocenters in one step to provide a wide variety of substituted diaziridines with high yields and diastereoselectivities.
doi_str_mv 10.1039/c5cc04813c
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source Royal Society Of Chemistry Journals 2008-; Alma/SFX Local Collection
subjects Aldehydes
Amines
Hydroxides
Ketones
Scaffolds
Synthesis
title Diastereoselective synthesis of substituted diaziridines from simple ketones and aldehydes
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