Transition-metal-catalyzed intramolecular cyclization of amido(hetero)arylboronic acid aldehydes to isoquinolinones and derivatives

We report an innovative and simple three step high yielding synthesis of a library of 14 chiral isoquinolinone and azepinone derivatives with benzyl, pyridyl and thiophene cores starting from amidoarylboronic acid aldehydes. These products have potential for treating neurodegenerative diseases. The...

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Veröffentlicht in:	RSC advances 2015-01, Vol.5 (26), p.20108-20114
Hauptverfasser:	Marques, C. S., Peixoto, D., Burke, A. J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Aldehydes Catalysis Catalysts Derivatives Neurological diseases Pathways Synthesis Thiophenes
Online-Zugang:	Volltext
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