Evaluation of a Kinetic Model for Computer Simulation of Growth and Fermentation by Scheffersomyces (Pichia) stipitis Fed D-Xylose
Scheffersomyces (formly Pichia) stipitis is a potential biocatalyst for converting lignocelluloses to ethanol because the yeast natively ferments xylose. An unstructured kinetic model based upon a system of linear differential equations has been formulated that describes growth and ethanol productio...
Gespeichert in:
| Veröffentlicht in: | Biotechnology and bioengineering 2014-08, Vol.111 (8), p.1532-1540 |
|---|---|
| Hauptverfasser: | , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 1540 |
|---|---|
| container_issue | 8 |
| container_start_page | 1532 |
| container_title | Biotechnology and bioengineering |
| container_volume | 111 |
| creator | Slininger, P. J Dien, B. S Lomont, J. M Bothast, R. J Ladisch, M. R Okos, M. R |
| description | Scheffersomyces (formly Pichia) stipitis is a potential biocatalyst for converting lignocelluloses to ethanol because the yeast natively ferments xylose. An unstructured kinetic model based upon a system of linear differential equations has been formulated that describes growth and ethanol production as functions of ethanol, oxygen, and xylose concentrations for both growth and fermentation stages. The model was validated for various growth conditions including batch, cell recycle, batch with in situ ethanol removal and fed-batch. Integrating basic kinetic and physiological yeast properties, the model is an important predictive tool for simulating and optimizing various culture conditions and evaluating various bioreactor designs for ethanol production. |
| doi_str_mv | 10.1002/bit.25215 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1730086620</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>3366963401</sourcerecordid><originalsourceid>FETCH-LOGICAL-c6215-c0ea109bfe6b5b98699d0bba079fb4dda29291bb60f7e1646e199583bf2e20d83</originalsourceid><addsrcrecordid>eNqN0s1u1DAUBeAIgegPLHgBsMSmXaS9duI4XpahHaoWGGmmojvLTmzGJYkHO2mZLU-Oh7QjhITKKpby3SPdq5MkrzAcYQByrGx_RCjB9Emyi4GzFAiHp3-8d5K9EG4AgJVF8TzZITnFPMvy3eTn6a1sBtlb1yFnkEQXttO9rdBHV-sGGefRxLWrodcezW07NFs69e6uXyLZ1ehM-1Z3_fhLrdG8WmpjtA-uXVc6oIOZrZZWHqLQ25XtbYgTNXqfXq8bF_SL5JmRTdAv77_7ydXZ6WLyIb38PD2fnFymVRFXSyvQMi6kjC4UVbwsOK9BKQmMG5XXtSSccKxUAYZpXOSFxpzTMlOGaAJ1me0nB2Puyrvvgw69aG2odNPITrshCMwygHgfAo_TgpWUMhZv-CilNOcUCKX_QXOcsRzKTerbv-iNG3wXz7NRGSt5RlhUh6OqvAvBayNW3rbSrwUGsWmGiM0Qv5sR7ev7xEG1ut7KhypEcDyCO9vo9b-TxLvzxUNkOk7Y0Osf2wnpv4mCZYyKL5-mYraYLy4yMhPX0b8ZvZFOyK_eBnE1J4ApAAZWxOV_AZPe2Qk</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1543789327</pqid></control><display><type>article</type><title>Evaluation of a Kinetic Model for Computer Simulation of Growth and Fermentation by Scheffersomyces (Pichia) stipitis Fed D-Xylose</title><source>MEDLINE</source><source>Wiley Online Library Journals Frontfile Complete</source><creator>Slininger, P. J ; Dien, B. S ; Lomont, J. M ; Bothast, R. J ; Ladisch, M. R ; Okos, M. R</creator><creatorcontrib>Slininger, P. J ; Dien, B. S ; Lomont, J. M ; Bothast, R. J ; Ladisch, M. R ; Okos, M. R</creatorcontrib><description>Scheffersomyces (formly Pichia) stipitis is a potential biocatalyst for converting lignocelluloses to ethanol because the yeast natively ferments xylose. An unstructured kinetic model based upon a system of linear differential equations has been formulated that describes growth and ethanol production as functions of ethanol, oxygen, and xylose concentrations for both growth and fermentation stages. The model was validated for various growth conditions including batch, cell recycle, batch with in situ ethanol removal and fed-batch. Integrating basic kinetic and physiological yeast properties, the model is an important predictive tool for simulating and optimizing various culture conditions and evaluating various bioreactor designs for ethanol production.</description><identifier>ISSN: 1097-0290</identifier><identifier>ISSN: 0006-3592</identifier><identifier>EISSN: 1097-0290</identifier><identifier>DOI: 10.1002/bit.25215</identifier><identifier>PMID: 24519334</identifier><identifier>CODEN: BIBIAU</identifier><language>eng</language><publisher>United States: Blackwell Publishing Ltd</publisher><subject>batch fermentation ; Biocatalysts ; bioreactors ; cell recycle ; Computer Simulation ; Differential equations ; equations ; Ethanol ; Ethanol - metabolism ; ethanol fermentation ; ethanol production ; ethanol stripping ; Ethyl alcohol ; fed-batch ; Fermentation ; Kinetics ; lignocellulose ; linear models ; Mathematical models ; microbial growth ; model validation ; Models, Biological ; oxygen ; Oxygen - metabolism ; Pichia ; Pichia - growth & development ; Pichia - metabolism ; Pichia stipitis ; Scheffersomyces stipitis ; Simulation ; simulation models ; Xylose ; Xylose - metabolism ; Yeast ; yeasts</subject><ispartof>Biotechnology and bioengineering, 2014-08, Vol.111 (8), p.1532-1540</ispartof><rights>2014 Wiley Periodicals, Inc.</rights><rights>Copyright John Wiley and Sons, Limited Aug 2014</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c6215-c0ea109bfe6b5b98699d0bba079fb4dda29291bb60f7e1646e199583bf2e20d83</citedby><cites>FETCH-LOGICAL-c6215-c0ea109bfe6b5b98699d0bba079fb4dda29291bb60f7e1646e199583bf2e20d83</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fbit.25215$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fbit.25215$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24519334$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Slininger, P. J</creatorcontrib><creatorcontrib>Dien, B. S</creatorcontrib><creatorcontrib>Lomont, J. M</creatorcontrib><creatorcontrib>Bothast, R. J</creatorcontrib><creatorcontrib>Ladisch, M. R</creatorcontrib><creatorcontrib>Okos, M. R</creatorcontrib><title>Evaluation of a Kinetic Model for Computer Simulation of Growth and Fermentation by Scheffersomyces (Pichia) stipitis Fed D-Xylose</title><title>Biotechnology and bioengineering</title><addtitle>Biotechnol. Bioeng</addtitle><description>Scheffersomyces (formly Pichia) stipitis is a potential biocatalyst for converting lignocelluloses to ethanol because the yeast natively ferments xylose. An unstructured kinetic model based upon a system of linear differential equations has been formulated that describes growth and ethanol production as functions of ethanol, oxygen, and xylose concentrations for both growth and fermentation stages. The model was validated for various growth conditions including batch, cell recycle, batch with in situ ethanol removal and fed-batch. Integrating basic kinetic and physiological yeast properties, the model is an important predictive tool for simulating and optimizing various culture conditions and evaluating various bioreactor designs for ethanol production.</description><subject>batch fermentation</subject><subject>Biocatalysts</subject><subject>bioreactors</subject><subject>cell recycle</subject><subject>Computer Simulation</subject><subject>Differential equations</subject><subject>equations</subject><subject>Ethanol</subject><subject>Ethanol - metabolism</subject><subject>ethanol fermentation</subject><subject>ethanol production</subject><subject>ethanol stripping</subject><subject>Ethyl alcohol</subject><subject>fed-batch</subject><subject>Fermentation</subject><subject>Kinetics</subject><subject>lignocellulose</subject><subject>linear models</subject><subject>Mathematical models</subject><subject>microbial growth</subject><subject>model validation</subject><subject>Models, Biological</subject><subject>oxygen</subject><subject>Oxygen - metabolism</subject><subject>Pichia</subject><subject>Pichia - growth & development</subject><subject>Pichia - metabolism</subject><subject>Pichia stipitis</subject><subject>Scheffersomyces stipitis</subject><subject>Simulation</subject><subject>simulation models</subject><subject>Xylose</subject><subject>Xylose - metabolism</subject><subject>Yeast</subject><subject>yeasts</subject><issn>1097-0290</issn><issn>0006-3592</issn><issn>1097-0290</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqN0s1u1DAUBeAIgegPLHgBsMSmXaS9duI4XpahHaoWGGmmojvLTmzGJYkHO2mZLU-Oh7QjhITKKpby3SPdq5MkrzAcYQByrGx_RCjB9Emyi4GzFAiHp3-8d5K9EG4AgJVF8TzZITnFPMvy3eTn6a1sBtlb1yFnkEQXttO9rdBHV-sGGefRxLWrodcezW07NFs69e6uXyLZ1ehM-1Z3_fhLrdG8WmpjtA-uXVc6oIOZrZZWHqLQ25XtbYgTNXqfXq8bF_SL5JmRTdAv77_7ydXZ6WLyIb38PD2fnFymVRFXSyvQMi6kjC4UVbwsOK9BKQmMG5XXtSSccKxUAYZpXOSFxpzTMlOGaAJ1me0nB2Puyrvvgw69aG2odNPITrshCMwygHgfAo_TgpWUMhZv-CilNOcUCKX_QXOcsRzKTerbv-iNG3wXz7NRGSt5RlhUh6OqvAvBayNW3rbSrwUGsWmGiM0Qv5sR7ev7xEG1ut7KhypEcDyCO9vo9b-TxLvzxUNkOk7Y0Osf2wnpv4mCZYyKL5-mYraYLy4yMhPX0b8ZvZFOyK_eBnE1J4ApAAZWxOV_AZPe2Qk</recordid><startdate>201408</startdate><enddate>201408</enddate><creator>Slininger, P. J</creator><creator>Dien, B. S</creator><creator>Lomont, J. M</creator><creator>Bothast, R. J</creator><creator>Ladisch, M. R</creator><creator>Okos, M. R</creator><general>Blackwell Publishing Ltd</general><general>Wiley Subscription Services, Inc</general><scope>FBQ</scope><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QF</scope><scope>7QO</scope><scope>7QQ</scope><scope>7SC</scope><scope>7SE</scope><scope>7SP</scope><scope>7SR</scope><scope>7T7</scope><scope>7TA</scope><scope>7TB</scope><scope>7U5</scope><scope>8BQ</scope><scope>8FD</scope><scope>C1K</scope><scope>F28</scope><scope>FR3</scope><scope>H8D</scope><scope>H8G</scope><scope>JG9</scope><scope>JQ2</scope><scope>KR7</scope><scope>L7M</scope><scope>L~C</scope><scope>L~D</scope><scope>P64</scope><scope>7X8</scope><scope>7S9</scope><scope>L.6</scope></search><sort><creationdate>201408</creationdate><title>Evaluation of a Kinetic Model for Computer Simulation of Growth and Fermentation by Scheffersomyces (Pichia) stipitis Fed D-Xylose</title><author>Slininger, P. J ; Dien, B. S ; Lomont, J. M ; Bothast, R. J ; Ladisch, M. R ; Okos, M. R</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c6215-c0ea109bfe6b5b98699d0bba079fb4dda29291bb60f7e1646e199583bf2e20d83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>batch fermentation</topic><topic>Biocatalysts</topic><topic>bioreactors</topic><topic>cell recycle</topic><topic>Computer Simulation</topic><topic>Differential equations</topic><topic>equations</topic><topic>Ethanol</topic><topic>Ethanol - metabolism</topic><topic>ethanol fermentation</topic><topic>ethanol production</topic><topic>ethanol stripping</topic><topic>Ethyl alcohol</topic><topic>fed-batch</topic><topic>Fermentation</topic><topic>Kinetics</topic><topic>lignocellulose</topic><topic>linear models</topic><topic>Mathematical models</topic><topic>microbial growth</topic><topic>model validation</topic><topic>Models, Biological</topic><topic>oxygen</topic><topic>Oxygen - metabolism</topic><topic>Pichia</topic><topic>Pichia - growth & development</topic><topic>Pichia - metabolism</topic><topic>Pichia stipitis</topic><topic>Scheffersomyces stipitis</topic><topic>Simulation</topic><topic>simulation models</topic><topic>Xylose</topic><topic>Xylose - metabolism</topic><topic>Yeast</topic><topic>yeasts</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Slininger, P. J</creatorcontrib><creatorcontrib>Dien, B. S</creatorcontrib><creatorcontrib>Lomont, J. M</creatorcontrib><creatorcontrib>Bothast, R. J</creatorcontrib><creatorcontrib>Ladisch, M. R</creatorcontrib><creatorcontrib>Okos, M. R</creatorcontrib><collection>AGRIS</collection><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Aluminium Industry Abstracts</collection><collection>Biotechnology Research Abstracts</collection><collection>Ceramic Abstracts</collection><collection>Computer and Information Systems Abstracts</collection><collection>Corrosion Abstracts</collection><collection>Electronics & Communications Abstracts</collection><collection>Engineered Materials Abstracts</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Materials Business File</collection><collection>Mechanical & Transportation Engineering Abstracts</collection><collection>Solid State and Superconductivity Abstracts</collection><collection>METADEX</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ANTE: Abstracts in New Technology & Engineering</collection><collection>Engineering Research Database</collection><collection>Aerospace Database</collection><collection>Copper Technical Reference Library</collection><collection>Materials Research Database</collection><collection>ProQuest Computer Science Collection</collection><collection>Civil Engineering Abstracts</collection><collection>Advanced Technologies Database with Aerospace</collection><collection>Computer and Information Systems Abstracts Academic</collection><collection>Computer and Information Systems Abstracts Professional</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><collection>AGRICOLA</collection><collection>AGRICOLA - Academic</collection><jtitle>Biotechnology and bioengineering</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Slininger, P. J</au><au>Dien, B. S</au><au>Lomont, J. M</au><au>Bothast, R. J</au><au>Ladisch, M. R</au><au>Okos, M. R</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Evaluation of a Kinetic Model for Computer Simulation of Growth and Fermentation by Scheffersomyces (Pichia) stipitis Fed D-Xylose</atitle><jtitle>Biotechnology and bioengineering</jtitle><addtitle>Biotechnol. Bioeng</addtitle><date>2014-08</date><risdate>2014</risdate><volume>111</volume><issue>8</issue><spage>1532</spage><epage>1540</epage><pages>1532-1540</pages><issn>1097-0290</issn><issn>0006-3592</issn><eissn>1097-0290</eissn><coden>BIBIAU</coden><abstract>Scheffersomyces (formly Pichia) stipitis is a potential biocatalyst for converting lignocelluloses to ethanol because the yeast natively ferments xylose. An unstructured kinetic model based upon a system of linear differential equations has been formulated that describes growth and ethanol production as functions of ethanol, oxygen, and xylose concentrations for both growth and fermentation stages. The model was validated for various growth conditions including batch, cell recycle, batch with in situ ethanol removal and fed-batch. Integrating basic kinetic and physiological yeast properties, the model is an important predictive tool for simulating and optimizing various culture conditions and evaluating various bioreactor designs for ethanol production.</abstract><cop>United States</cop><pub>Blackwell Publishing Ltd</pub><pmid>24519334</pmid><doi>10.1002/bit.25215</doi><tpages>9</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1097-0290 |
| ispartof | Biotechnology and bioengineering, 2014-08, Vol.111 (8), p.1532-1540 |
| issn | 1097-0290 0006-3592 1097-0290 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1730086620 |
| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | batch fermentation Biocatalysts bioreactors cell recycle Computer Simulation Differential equations equations Ethanol Ethanol - metabolism ethanol fermentation ethanol production ethanol stripping Ethyl alcohol fed-batch Fermentation Kinetics lignocellulose linear models Mathematical models microbial growth model validation Models, Biological oxygen Oxygen - metabolism Pichia Pichia - growth & development Pichia - metabolism Pichia stipitis Scheffersomyces stipitis Simulation simulation models Xylose Xylose - metabolism Yeast yeasts |
| title | Evaluation of a Kinetic Model for Computer Simulation of Growth and Fermentation by Scheffersomyces (Pichia) stipitis Fed D-Xylose |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-12T21%3A19%3A38IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Evaluation%20of%20a%20Kinetic%20Model%20for%20Computer%20Simulation%20of%20Growth%20and%20Fermentation%20by%20Scheffersomyces%20(Pichia)%20stipitis%20Fed%20D-Xylose&rft.jtitle=Biotechnology%20and%20bioengineering&rft.au=Slininger,%20P.%20J&rft.date=2014-08&rft.volume=111&rft.issue=8&rft.spage=1532&rft.epage=1540&rft.pages=1532-1540&rft.issn=1097-0290&rft.eissn=1097-0290&rft.coden=BIBIAU&rft_id=info:doi/10.1002/bit.25215&rft_dat=%3Cproquest_cross%3E3366963401%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1543789327&rft_id=info:pmid/24519334&rfr_iscdi=true |