Chemical and physical properties of carbonated hydroxyapatite affect breast cancer cell behavior

[Display omitted] Breast microcalcifications are routinely explored for mammographic detection of breast cancer and are primarily composed of non-stoichiometric hydroxyapatite (Ca10−x(PO4)6−x(CO3)x(OH)2−x) (HA). Interestingly, HA morphology and carbonate substitution vary in malignant vs. benign les...

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Veröffentlicht in:	Acta biomaterialia 2015-09, Vol.24, p.333-342
Hauptverfasser:	Choi, Siyoung, Coonrod, Scott, Estroff, Lara, Fischbach, Claudia
Format:	Artikel
Sprache:	eng
Schlagworte:	Breast Breast cancer malignancy Breast Neoplasms - metabolism Breast Neoplasms - pathology Cancer Carbonate contents Carbonates Carbonates - pharmacokinetics Carbonates - pharmacology Culture Culture platform Durapatite - pharmacokinetics Durapatite - pharmacology Female Humans Hydroxyapatite Interleukin-8 - metabolism Mammography MCF-7 Cells Microcalcifications Morphology Neoplasm Proteins - metabolism Platforms Secretions
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