Pd-catalyzed direct C2-acylation and C2,C7-diacylation of indoles: pyrimidine as an easily removable C–H directing group
Pyrimidine is successfully used as an easily removable C(sp 2 )–H directing group for the synthesis of 2-acyl indoles and 2,7-diacyl indoles through direct C–H functionalization using a Pd-catalyst from 1-(pyrimidin-2-yl)-1 H -indoles and aldehydes. Easy removal of the pyrimidine directing group usi...
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| Veröffentlicht in: | RSC advances 2015-01, Vol.5 (36), p.28292-28298 |
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| container_end_page | 28298 |
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| container_issue | 36 |
| container_start_page | 28292 |
| container_title | RSC advances |
| container_volume | 5 |
| creator | Kumar, Govindharaj Sekar, Govindasamy |
| description | Pyrimidine is successfully used as an easily removable C(sp
2
)–H directing group for the synthesis of 2-acyl indoles and 2,7-diacyl indoles through direct C–H functionalization using a Pd-catalyst from 1-(pyrimidin-2-yl)-1
H
-indoles and aldehydes. Easy removal of the pyrimidine directing group using EtONa in DMSO provides C2-acyl indoles. |
| doi_str_mv | 10.1039/C4RA15162C |
| format | Article |
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2
)–H directing group for the synthesis of 2-acyl indoles and 2,7-diacyl indoles through direct C–H functionalization using a Pd-catalyst from 1-(pyrimidin-2-yl)-1
H
-indoles and aldehydes. Easy removal of the pyrimidine directing group using EtONa in DMSO provides C2-acyl indoles.</abstract><doi>10.1039/C4RA15162C</doi><tpages>7</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 2046-2069 |
| ispartof | RSC advances, 2015-01, Vol.5 (36), p.28292-28298 |
| issn | 2046-2069 2046-2069 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1730070306 |
| source | Royal Society Of Chemistry Journals 2008- |
| subjects | Aldehydes Indoles Palladium Pyrimidines Synthesis |
| title | Pd-catalyzed direct C2-acylation and C2,C7-diacylation of indoles: pyrimidine as an easily removable C–H directing group |
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