Novel Inorganic Gatekeeper Strategy for Obtaining Controlled Release in Mesoporous Silica Nanoparticles

A relatively facile and adjustable approach was investigated to synthesize mesoporous silica nanoparticles (MSNs) with a thin controllable solid silica-cap (sSiO2) outer layer that prevented unwanted degradation for controlled drug release because the sSiO2 turned out to degrade gradually. Ibuprofen...

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Veröffentlicht in:	Chemistry letters 2014, Vol.43 (6), p.854-856
Hauptverfasser:	Peng, Ce, Alec, Nicol, Zhao, Miaomiao, Cai, Qiang, Yao, Youwei, Wang, Xiumei, Sun, Xiaodan
Format:	Artikel
Sprache:	eng
Schlagworte:	Adjustable Controlled release Degradation Ibuprofen Nanoparticles Silicon dioxide Stability Strategy
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creator	Peng, Ce Alec, Nicol Zhao, Miaomiao Cai, Qiang Yao, Youwei Wang, Xiumei Sun, Xiaodan
description	A relatively facile and adjustable approach was investigated to synthesize mesoporous silica nanoparticles (MSNs) with a thin controllable solid silica-cap (sSiO2) outer layer that prevented unwanted degradation for controlled drug release because the sSiO2 turned out to degrade gradually. Ibuprofen (IBU) and calcium ions were loaded to evaluate the efficiency of this system. This sSiO2-capped degradation strategy for controlled release could easily be extended to other pH- or temperature-responsive MSN systems and applications.
doi_str_mv	10.1246/cl.140142
format	Article
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source	Oxford University Press Journals All Titles (1996-Current)
subjects	Adjustable Controlled release Degradation Ibuprofen Nanoparticles Silicon dioxide Stability Strategy
title	Novel Inorganic Gatekeeper Strategy for Obtaining Controlled Release in Mesoporous Silica Nanoparticles
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