Highly regio- and diastereoselective construction of spirocyclopenteneoxindole phosphonates through a phosphine-catalyzed [3 + 2] annulation reaction

Highly regio- and diastereoselective construction of spirocyclopenteneoxindole phosphonates through a phosphine-catalyzed [3 + 2] annulation reaction

A phosphine-catalyzed [3 + 2] annulation of MBH phosphonates with isatylidene malononitriles is developed. The described method, which is different from most traditional phosphorus ylide intermediate reaction modes of MBH carbonates with isatylidene malononitriles, represents a novel approach to hig...

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Veröffentlicht in:RSC advances 2014-01, Vol.4 (108), p.63246-63253
Hauptverfasser: Yu, Chengbin, Zheng, Weiping, Zhan, Junchen, Sun, Yuchao, Miao, Zhiwei
Format: Artikel
Sprache:eng
Schlagworte:
Carbonates
Chemical reactions
Construction
Malononitrile
Organic chemistry
Phosphonates
Phosphorus
Synthesis
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Beschreibung
Zusammenfassung:A phosphine-catalyzed [3 + 2] annulation of MBH phosphonates with isatylidene malononitriles is developed. The described method, which is different from most traditional phosphorus ylide intermediate reaction modes of MBH carbonates with isatylidene malononitriles, represents a novel approach to highly regioselective and diastereoselective synthesis of spirocyclopenteneoxindole phosphonates.
ISSN:2046-2069
2046-2069
DOI:10.1039/C4RA12997K