Design and synthesis of pyrrole–5-(2,6-dichlorobenzyl)sulfonylindolin-2-ones with C-3′ side chains as potent Met kinase inhibitors

Pyrrole–5-(2,6-dichlorobenzyl)sulfonylindolin-2-ones of scaffold 4 with various C-3′ side chains were designed as potent Met kinase inhibitors. Structural optimization led to compounds 10 , 20 , and 22–24 which demonstrated subnanomolar IC 50 values in the biochemical assay. The potent compound 20 i...

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Veröffentlicht in:	RSC advances 2014-01, Vol.4 (103), p.58990-58998
Hauptverfasser:	Liu, Chia-Wei, Lai, Chun-Liang, Lin, Yu-Hsiang, Teng, Li-Wei, Yang, Sheng-chuan, Wei, Win-Yin, Lin, Shu Fu, Yang, Ju-Ying, Huang, Hung-Jyun, Wang, Ru-Wen, Chiang, Chao-Cheng, Lee, Mei-Hui, Wang, Yu-Chuan, Chuang, Shih-Hsien, Chang, Jia-Ming, Lee, Ying-Shuan E., Huang, Jiann-Jyh
Format:	Artikel
Sprache:	eng
Schlagworte:	Biochemistry Computation Computer simulation Inhibitors Kinases Optimization Scaffolds Synthesis
Online-Zugang:	Volltext
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