Lipiduria – with special relevance to Fabry disease
Examination of the urine under the microscope using polarised light is invaluable for detecting and identifying lipid particles. Attention to the shape of these Maltese cross bearing bodies can distinguish conventional fat particles from Fabry bodies with great sensitivity and specificity across a w...
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| Veröffentlicht in: | Clinical chemistry and laboratory medicine 2015-11, Vol.53 (2), p.1465-1470 |
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| container_title | Clinical chemistry and laboratory medicine |
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| creator | Becker, Gavin J. Nicholls, Kathleen |
| description | Examination of the urine under the microscope using polarised light is invaluable for detecting and identifying lipid particles. Attention to the shape of these Maltese cross bearing bodies can distinguish conventional fat particles from Fabry bodies with great sensitivity and specificity across a wide phenotypic spectrum. This could be a cheap and rapid tool for screening subjects suspected of having Fabry disease for renal involvement. It remains to be seen whether there is value in integrating polarised light into automated urine microscopy machines, but potentially this could greatly help the pathologist or nephrologist in identifying unusual urinary particles, and broaden the capacity for larger scale screening. |
| doi_str_mv | 10.1515/cclm-2015-0499 |
| format | Article |
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Attention to the shape of these Maltese cross bearing bodies can distinguish conventional fat particles from Fabry bodies with great sensitivity and specificity across a wide phenotypic spectrum. This could be a cheap and rapid tool for screening subjects suspected of having Fabry disease for renal involvement. It remains to be seen whether there is value in integrating polarised light into automated urine microscopy machines, but potentially this could greatly help the pathologist or nephrologist in identifying unusual urinary particles, and broaden the capacity for larger scale screening.</description><identifier>ISSN: 1434-6621</identifier><identifier>EISSN: 1437-4331</identifier><identifier>DOI: 10.1515/cclm-2015-0499</identifier><identifier>PMID: 26124059</identifier><language>eng</language><publisher>Germany: De Gruyter</publisher><subject>albuminuria ; Fabry ; Fabry Disease - urine ; Humans ; Kidney - chemistry ; Kidney - physiology ; Lipids - urine ; lipiduria ; microscopy ; Microscopy - methods ; renal ; Sensitivity and Specificity ; Urinalysis - methods</subject><ispartof>Clinical chemistry and laboratory medicine, 2015-11, Vol.53 (2), p.1465-1470</ispartof><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c391t-7272fff6e36cbff0fb65ea37a85851290af0049e3eb96bd51bb0b06019ffd9ef3</citedby><cites>FETCH-LOGICAL-c391t-7272fff6e36cbff0fb65ea37a85851290af0049e3eb96bd51bb0b06019ffd9ef3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.degruyter.com/document/doi/10.1515/cclm-2015-0499/pdf$$EPDF$$P50$$Gwalterdegruyter$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.degruyter.com/document/doi/10.1515/cclm-2015-0499/html$$EHTML$$P50$$Gwalterdegruyter$$Hfree_for_read</linktohtml><link.rule.ids>314,776,780,27901,27902,66497,68281</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26124059$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Becker, Gavin J.</creatorcontrib><creatorcontrib>Nicholls, Kathleen</creatorcontrib><title>Lipiduria – with special relevance to Fabry disease</title><title>Clinical chemistry and laboratory medicine</title><addtitle>Clin Chem Lab Med</addtitle><description>Examination of the urine under the microscope using polarised light is invaluable for detecting and identifying lipid particles. 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It remains to be seen whether there is value in integrating polarised light into automated urine microscopy machines, but potentially this could greatly help the pathologist or nephrologist in identifying unusual urinary particles, and broaden the capacity for larger scale screening.</description><subject>albuminuria</subject><subject>Fabry</subject><subject>Fabry Disease - urine</subject><subject>Humans</subject><subject>Kidney - chemistry</subject><subject>Kidney - physiology</subject><subject>Lipids - urine</subject><subject>lipiduria</subject><subject>microscopy</subject><subject>Microscopy - methods</subject><subject>renal</subject><subject>Sensitivity and Specificity</subject><subject>Urinalysis - methods</subject><issn>1434-6621</issn><issn>1437-4331</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kL1OwzAURi0EoqWwMqKMLCn-Tz0hVFFAqsQCs2Un15AqaYKdUHXjHXhDngSHFjam-w3nfrr3IHRO8JQIIq7yvKpTiolIMVfqAI0JZ1nKGSOHP5mnUlIyQichrHDEBM-O0YhKQjkWaozEsmzLovelSb4-PpNN2b0moYW8NFXioYJ3s84h6ZpkYazfJkUZwAQ4RUfOVAHO9nOCnhe3T_P7dPl49zC_WaY5U6RLM5pR55wEJnPrHHZWCjAsMzMxE4QqbByOZwMDq6QtBLEWWywxUc4VChyboMtdb-ubtx5Cp-sy5FBVZg1NHzTJGMY0fssjOt2huW9C8OB068va-K0mWA-q9KBKD6r0oCouXOy7e1tD8Yf_uonA9Q7YmKoDX8CL77cx6FXT-3V8-59mwQINhEvBvgHCLXn1</recordid><startdate>20151101</startdate><enddate>20151101</enddate><creator>Becker, Gavin J.</creator><creator>Nicholls, Kathleen</creator><general>De Gruyter</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20151101</creationdate><title>Lipiduria – with special relevance to Fabry disease</title><author>Becker, Gavin J. ; Nicholls, Kathleen</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c391t-7272fff6e36cbff0fb65ea37a85851290af0049e3eb96bd51bb0b06019ffd9ef3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>albuminuria</topic><topic>Fabry</topic><topic>Fabry Disease - urine</topic><topic>Humans</topic><topic>Kidney - chemistry</topic><topic>Kidney - physiology</topic><topic>Lipids - urine</topic><topic>lipiduria</topic><topic>microscopy</topic><topic>Microscopy - methods</topic><topic>renal</topic><topic>Sensitivity and Specificity</topic><topic>Urinalysis - methods</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Becker, Gavin J.</creatorcontrib><creatorcontrib>Nicholls, Kathleen</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Clinical chemistry and laboratory medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Becker, Gavin J.</au><au>Nicholls, Kathleen</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Lipiduria – with special relevance to Fabry disease</atitle><jtitle>Clinical chemistry and laboratory medicine</jtitle><addtitle>Clin Chem Lab Med</addtitle><date>2015-11-01</date><risdate>2015</risdate><volume>53</volume><issue>2</issue><spage>1465</spage><epage>1470</epage><pages>1465-1470</pages><issn>1434-6621</issn><eissn>1437-4331</eissn><abstract>Examination of the urine under the microscope using polarised light is invaluable for detecting and identifying lipid particles. 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| ispartof | Clinical chemistry and laboratory medicine, 2015-11, Vol.53 (2), p.1465-1470 |
| issn | 1434-6621 1437-4331 |
| language | eng |
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| source | MEDLINE; De Gruyter journals |
| subjects | albuminuria Fabry Fabry Disease - urine Humans Kidney - chemistry Kidney - physiology Lipids - urine lipiduria microscopy Microscopy - methods renal Sensitivity and Specificity Urinalysis - methods |
| title | Lipiduria – with special relevance to Fabry disease |
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