Effects of oral intake of plasmacytoid dendritic cells-stimulative lactic acid bacterial strain on pathogenesis of influenza-like illness and immunological response to influenza virus
Lactococcus lactis ssp. lactis JCM5805 has been shown to be a rare lactic acid bacterium that can activate plasmacytoid dendritic cells in both murine and human species. In this study, we carried out a randomised placebo-controlled double-blind experiment to evaluate its effect on the pathogenesis o...
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| Veröffentlicht in: | British journal of nutrition 2015-09, Vol.114 (5), p.727-733 |
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| creator | Sugimura, Tetsu Takahashi, Hitoshi Jounai, Kenta Ohshio, Konomi Kanayama, Masaya Tazumi, Kyoko Tanihata, Yoko Miura, Yutaka Fujiwara, Daisuke Yamamoto, Norio |
| description | Lactococcus lactis ssp. lactis JCM5805 has been shown to be a rare lactic acid bacterium that can activate plasmacytoid dendritic cells in both murine and human species. In this study, we carried out a randomised placebo-controlled double-blind experiment to evaluate its effect on the pathogenesis of influenza-like illness during the winter season. A total of 213 volunteers were divided into two groups, which received either yogurt made with L. lactis JCM5805 or a placebo beverage daily for 10 weeks. In the JCM5805 group, the cumulative incidence days of ‘cough’ and ‘feverishness’, which are defined as major symptoms of an influenza-like illness, were significantly decreased compared with the placebo group. In addition, peripheral blood mononuclear cells prepared from volunteers were cultured in the presence of inactivated human influenza virus A/H1N1 (A/PR/8/34). IFN-α elicited by A/H1N1 tended to be higher in the JCM5805 group compared with the placebo group, and an IFN-α-inducible antiviral factor, interferon-stimulated gene 15 (ISG15), elicited by A/H1N1 was significantly higher in the JCM5805 group compared with the placebo group after the intake period. These results suggest that intake of JCM5805 is able to prevent the pathogenesis of an influenza-like illness via enhancement of an IFN-α-mediated response to the influenza virus. |
| doi_str_mv | 10.1017/S0007114515002408 |
| format | Article |
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In this study, we carried out a randomised placebo-controlled double-blind experiment to evaluate its effect on the pathogenesis of influenza-like illness during the winter season. A total of 213 volunteers were divided into two groups, which received either yogurt made with L. lactis JCM5805 or a placebo beverage daily for 10 weeks. In the JCM5805 group, the cumulative incidence days of ‘cough’ and ‘feverishness’, which are defined as major symptoms of an influenza-like illness, were significantly decreased compared with the placebo group. In addition, peripheral blood mononuclear cells prepared from volunteers were cultured in the presence of inactivated human influenza virus A/H1N1 (A/PR/8/34). IFN-α elicited by A/H1N1 tended to be higher in the JCM5805 group compared with the placebo group, and an IFN-α-inducible antiviral factor, interferon-stimulated gene 15 (ISG15), elicited by A/H1N1 was significantly higher in the JCM5805 group compared with the placebo group after the intake period. These results suggest that intake of JCM5805 is able to prevent the pathogenesis of an influenza-like illness via enhancement of an IFN-α-mediated response to the influenza virus.</description><identifier>ISSN: 0007-1145</identifier><identifier>EISSN: 1475-2662</identifier><identifier>DOI: 10.1017/S0007114515002408</identifier><identifier>PMID: 26234407</identifier><language>eng</language><publisher>Cambridge, UK: Cambridge University Press</publisher><subject>Acids ; Administration, Oral ; Adult ; Bacteria ; Cells ; Cells, Cultured ; Dendritic Cells - immunology ; Double-Blind Method ; Humans ; Immunology ; Influenza ; Influenza A virus ; Influenza A Virus, H1N1 Subtype ; Influenza virus ; Influenza, Human - immunology ; Influenza, Human - metabolism ; Influenza, Human - prevention & control ; Influenza, Human - virology ; Interferon-alpha - metabolism ; Lactic Acid ; Lactococcus lactis ; Lactococcus lactis - immunology ; Leukocytes, Mononuclear - immunology ; Leukocytes, Mononuclear - metabolism ; Middle Aged ; Nutritional Immunology ; Pathogenesis ; Probiotics ; Seasons ; Yogurt - microbiology</subject><ispartof>British journal of nutrition, 2015-09, Vol.114 (5), p.727-733</ispartof><rights>Copyright © The Authors 2015</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c585t-15c8e225187b486b9da72323c88c548dc7cf7620743cdbe0cde16a8eca2f20fb3</citedby><cites>FETCH-LOGICAL-c585t-15c8e225187b486b9da72323c88c548dc7cf7620743cdbe0cde16a8eca2f20fb3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.cambridge.org/core/product/identifier/S0007114515002408/type/journal_article$$EHTML$$P50$$Gcambridge$$H</linktohtml><link.rule.ids>164,315,781,785,27929,27930,55633</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26234407$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Sugimura, Tetsu</creatorcontrib><creatorcontrib>Takahashi, Hitoshi</creatorcontrib><creatorcontrib>Jounai, Kenta</creatorcontrib><creatorcontrib>Ohshio, Konomi</creatorcontrib><creatorcontrib>Kanayama, Masaya</creatorcontrib><creatorcontrib>Tazumi, Kyoko</creatorcontrib><creatorcontrib>Tanihata, Yoko</creatorcontrib><creatorcontrib>Miura, Yutaka</creatorcontrib><creatorcontrib>Fujiwara, Daisuke</creatorcontrib><creatorcontrib>Yamamoto, Norio</creatorcontrib><title>Effects of oral intake of plasmacytoid dendritic cells-stimulative lactic acid bacterial strain on pathogenesis of influenza-like illness and immunological response to influenza virus</title><title>British journal of nutrition</title><addtitle>Br J Nutr</addtitle><description>Lactococcus lactis ssp. lactis JCM5805 has been shown to be a rare lactic acid bacterium that can activate plasmacytoid dendritic cells in both murine and human species. In this study, we carried out a randomised placebo-controlled double-blind experiment to evaluate its effect on the pathogenesis of influenza-like illness during the winter season. A total of 213 volunteers were divided into two groups, which received either yogurt made with L. lactis JCM5805 or a placebo beverage daily for 10 weeks. In the JCM5805 group, the cumulative incidence days of ‘cough’ and ‘feverishness’, which are defined as major symptoms of an influenza-like illness, were significantly decreased compared with the placebo group. In addition, peripheral blood mononuclear cells prepared from volunteers were cultured in the presence of inactivated human influenza virus A/H1N1 (A/PR/8/34). IFN-α elicited by A/H1N1 tended to be higher in the JCM5805 group compared with the placebo group, and an IFN-α-inducible antiviral factor, interferon-stimulated gene 15 (ISG15), elicited by A/H1N1 was significantly higher in the JCM5805 group compared with the placebo group after the intake period. These results suggest that intake of JCM5805 is able to prevent the pathogenesis of an influenza-like illness via enhancement of an IFN-α-mediated response to the influenza virus.</description><subject>Acids</subject><subject>Administration, Oral</subject><subject>Adult</subject><subject>Bacteria</subject><subject>Cells</subject><subject>Cells, Cultured</subject><subject>Dendritic Cells - immunology</subject><subject>Double-Blind Method</subject><subject>Humans</subject><subject>Immunology</subject><subject>Influenza</subject><subject>Influenza A virus</subject><subject>Influenza A Virus, H1N1 Subtype</subject><subject>Influenza virus</subject><subject>Influenza, Human - immunology</subject><subject>Influenza, Human - metabolism</subject><subject>Influenza, Human - prevention & control</subject><subject>Influenza, Human - virology</subject><subject>Interferon-alpha - metabolism</subject><subject>Lactic Acid</subject><subject>Lactococcus lactis</subject><subject>Lactococcus lactis - immunology</subject><subject>Leukocytes, Mononuclear - immunology</subject><subject>Leukocytes, Mononuclear - metabolism</subject><subject>Middle Aged</subject><subject>Nutritional Immunology</subject><subject>Pathogenesis</subject><subject>Probiotics</subject><subject>Seasons</subject><subject>Yogurt - microbiology</subject><issn>0007-1145</issn><issn>1475-2662</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNqNkstu1TAQhi0EoqcHHoANssSGTcC3xD5LVLWAVIlF23Xk2JODi2MH26nUvhivh0MPF1EhsbE9-r_5RzMehF5Q8oYSKt9eEEIkpaKlLSFMEPUIbaiQbcO6jj1Gm1VuVv0IHed8XUNFye4pOmId40IQuUHfTscRTMk4jjgm7bELRX-BNZy9zpM2tyU6iy0Em1xxBhvwPje5uGnxurgbwF6bVdCmckN9Q3LVKJekXcAx4FmXz3EPAbL7UceF0S8Q7nTjXS3lvK9SxjpY7KZpCdHHvTPVIkGeY8iAS_ydhG9cWvIz9GTUPsPzw71FV2enlycfmvNP7z-evDtvTKva0tDWKGCspUoOQnXDzmrJOONGKdMKZY00o-wYkYIbOwAxFminFRjNRkbGgW_R63vfOcWvC-TSTy6vI9AB4pJ7KnkdPadK_AfKZLfbqW5FX_2FXsclhdpIpSjjLeX13CJ6T5kUc04w9nNyk063PSX9ugD9gwWoOS8Pzsswgf2V8fPHK8APpnoakrN7-KP2P22_A-ShvkM</recordid><startdate>20150914</startdate><enddate>20150914</enddate><creator>Sugimura, Tetsu</creator><creator>Takahashi, Hitoshi</creator><creator>Jounai, Kenta</creator><creator>Ohshio, Konomi</creator><creator>Kanayama, Masaya</creator><creator>Tazumi, Kyoko</creator><creator>Tanihata, Yoko</creator><creator>Miura, Yutaka</creator><creator>Fujiwara, Daisuke</creator><creator>Yamamoto, Norio</creator><general>Cambridge University Press</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QP</scope><scope>7RV</scope><scope>7T5</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8C1</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AN0</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB0</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>MBDVC</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope><scope>7QL</scope><scope>7T7</scope><scope>7U9</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>20150914</creationdate><title>Effects of oral intake of plasmacytoid dendritic cells-stimulative lactic acid bacterial strain on pathogenesis of influenza-like illness and immunological response to influenza virus</title><author>Sugimura, Tetsu ; Takahashi, Hitoshi ; Jounai, Kenta ; Ohshio, Konomi ; Kanayama, Masaya ; Tazumi, Kyoko ; Tanihata, Yoko ; Miura, Yutaka ; Fujiwara, Daisuke ; Yamamoto, Norio</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c585t-15c8e225187b486b9da72323c88c548dc7cf7620743cdbe0cde16a8eca2f20fb3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Acids</topic><topic>Administration, Oral</topic><topic>Adult</topic><topic>Bacteria</topic><topic>Cells</topic><topic>Cells, Cultured</topic><topic>Dendritic Cells - 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Academic</collection><jtitle>British journal of nutrition</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sugimura, Tetsu</au><au>Takahashi, Hitoshi</au><au>Jounai, Kenta</au><au>Ohshio, Konomi</au><au>Kanayama, Masaya</au><au>Tazumi, Kyoko</au><au>Tanihata, Yoko</au><au>Miura, Yutaka</au><au>Fujiwara, Daisuke</au><au>Yamamoto, Norio</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effects of oral intake of plasmacytoid dendritic cells-stimulative lactic acid bacterial strain on pathogenesis of influenza-like illness and immunological response to influenza virus</atitle><jtitle>British journal of nutrition</jtitle><addtitle>Br J Nutr</addtitle><date>2015-09-14</date><risdate>2015</risdate><volume>114</volume><issue>5</issue><spage>727</spage><epage>733</epage><pages>727-733</pages><issn>0007-1145</issn><eissn>1475-2662</eissn><abstract>Lactococcus lactis ssp. lactis JCM5805 has been shown to be a rare lactic acid bacterium that can activate plasmacytoid dendritic cells in both murine and human species. In this study, we carried out a randomised placebo-controlled double-blind experiment to evaluate its effect on the pathogenesis of influenza-like illness during the winter season. A total of 213 volunteers were divided into two groups, which received either yogurt made with L. lactis JCM5805 or a placebo beverage daily for 10 weeks. In the JCM5805 group, the cumulative incidence days of ‘cough’ and ‘feverishness’, which are defined as major symptoms of an influenza-like illness, were significantly decreased compared with the placebo group. In addition, peripheral blood mononuclear cells prepared from volunteers were cultured in the presence of inactivated human influenza virus A/H1N1 (A/PR/8/34). IFN-α elicited by A/H1N1 tended to be higher in the JCM5805 group compared with the placebo group, and an IFN-α-inducible antiviral factor, interferon-stimulated gene 15 (ISG15), elicited by A/H1N1 was significantly higher in the JCM5805 group compared with the placebo group after the intake period. These results suggest that intake of JCM5805 is able to prevent the pathogenesis of an influenza-like illness via enhancement of an IFN-α-mediated response to the influenza virus.</abstract><cop>Cambridge, UK</cop><pub>Cambridge University Press</pub><pmid>26234407</pmid><doi>10.1017/S0007114515002408</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Acids Administration, Oral Adult Bacteria Cells Cells, Cultured Dendritic Cells - immunology Double-Blind Method Humans Immunology Influenza Influenza A virus Influenza A Virus, H1N1 Subtype Influenza virus Influenza, Human - immunology Influenza, Human - metabolism Influenza, Human - prevention & control Influenza, Human - virology Interferon-alpha - metabolism Lactic Acid Lactococcus lactis Lactococcus lactis - immunology Leukocytes, Mononuclear - immunology Leukocytes, Mononuclear - metabolism Middle Aged Nutritional Immunology Pathogenesis Probiotics Seasons Yogurt - microbiology |
| title | Effects of oral intake of plasmacytoid dendritic cells-stimulative lactic acid bacterial strain on pathogenesis of influenza-like illness and immunological response to influenza virus |
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