Gabapentin attenuates neuropathic pain and improves nerve myelination after chronic sciatic constriction in rats

•Gabapentin improves myelin basic protein expression in the injured sciatic nerve.•Gabapentin ameliorates neuropathic pain behaviors.•Gabapentin has a dual role in improving neuropathic pain and nerve myelination following sciatic nerve injury. Gabapentin (GBP) is an anti-convulsive drug often used...

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Veröffentlicht in:	Neuroscience letters 2015-10, Vol.607, p.52-58
Hauptverfasser:	Câmara, Carlos C., Araújo, Celina V., de Sousa, Kalina Kelma Oliveira, Brito, Gerly A.C., Vale, Mariana L., Raposo, Ramon da Silva, Mendonça, Fabiana Evaristo, Mietto, Bruno S., Martinez, Ana Maria B., Oriá, Reinaldo B.
Format:	Artikel
Sprache:	eng
Schlagworte:	Amines - pharmacology Amines - therapeutic use Animals Anticonvulsants - pharmacology Anticonvulsants - therapeutic use Constriction, Pathologic Cyclohexanecarboxylic Acids - pharmacology Cyclohexanecarboxylic Acids - therapeutic use Gabapentin gamma-Aminobutyric Acid - pharmacology gamma-Aminobutyric Acid - therapeutic use Male Myelin Basic Protein - metabolism Nerve myelination Nerve Regeneration Neuralgia - drug therapy Neuralgia - etiology Neuralgia - physiopathology Neuropathic pain Rats, Wistar Sciatic nerve Sciatic Nerve - drug effects Sciatic Nerve - injuries Sciatic Nerve - metabolism
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