Inverse Agonist of Estrogen-Related Receptor γ Enhances Sodium Iodide Symporter Function Through Mitogen-Activated Protein Kinase Signaling in Anaplastic Thyroid Cancer Cells

Anaplastic thyroid cancer (ATC), a rare thyroid cancer with poor prognosis, is associated with insufficient function of the sodium iodide symporter (NIS). Estrogen-related receptor γ (ERRγ) is a member of the orphan nuclear receptors with important functions in cell development and homeostasis. Howe...

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Veröffentlicht in:	Journal of Nuclear Medicine 2015-11, Vol.56 (11), p.1690-1696
Hauptverfasser:	Singh, Thoudam Debraj, Jeong, Shin Young, Lee, Sang-Woo, Ha, Jeoung-Hee, Lee, In-Kyu, Kim, Seong Heon, Kim, Jina, Cho, Sung Jin, Ahn, Byeong-Cheol, Lee, Jaetae, Jeon, Young Hyun
Format:	Artikel
Sprache:	eng
Schlagworte:	Blotting, Western Cell Line, Tumor Estrogen Receptor Modulators - pharmacology Humans Iodine Radioisotopes - metabolism MAP Kinase Signaling System - drug effects Mitogen-Activated Protein Kinases - antagonists & inhibitors Protein Kinase Inhibitors - pharmacology Receptors, Estrogen - drug effects Symporters - metabolism Tamoxifen - analogs & derivatives Tamoxifen - pharmacology Tamoxifen - therapeutic use Thyroid Carcinoma, Anaplastic - metabolism Thyroid Neoplasms - metabolism Tumor Stem Cell Assay
Online-Zugang:	Volltext
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