Interaction of benztropine and haloperidol actions on rat substantia nigra dopamine cell electrophysiological activity in vivo

Despite the known efficacy of antimuscarinic agents in treating dopamine-related movement disorders, their effects on dopamine cell activity have not been well studied. We investigated the effects of systemically administered benztropine, an antimuscarinic agent that also inhibits the dopamine trans...

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Veröffentlicht in:	Brain research bulletin 1999-01, Vol.48 (2), p.219-222
Hauptverfasser:	Todd, Christopher L, Grace, Anthony A
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylcholine Acute dystonia Animals Antipsychotic drugs Benztropine - pharmacology Biological and medical sciences Dopamine Dopamine Antagonists - pharmacology Dopamine transporter Dose-Response Relationship, Drug Drug Interactions Electrophysiology Extrapyramidal side effects Haloperidol - pharmacology Male Medical sciences Muscarinic Muscarinic Antagonists - pharmacology Neuropharmacology Pharmacology. Drug treatments Psycholeptics: tranquillizer, neuroleptic Psychology. Psychoanalysis. Psychiatry Psychopharmacology Rats Rats, Sprague-Dawley Single-unit recording Substantia Nigra - cytology Substantia Nigra - drug effects Substantia Nigra - physiology
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