Screening and Characterization of Hydrate Forms of T-3256336, a Novel Inhibitor of Apoptosis (IAP) Protein Antagonist

Different crystal packing of hydrates from anhydrate crystals leads to different physical properties, such as solubility and stability. Investigation of the potential of varied hydrate formation, and understanding the stability in an anhydrous/hydrate system, are crucial to prevent an undesired tran...

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Veröffentlicht in:	Chemical & pharmaceutical bulletin 2015/11/01, Vol.63(11), pp.858-865
Hauptverfasser:	Takeuchi, Shoko, Kojima, Takashi, Hashimoto, Kentaro, Saito, Bunnai, Sumi, Hiroyuki, Ishikawa, Tomoyasu, Ikeda, Yukihiro
Format:	Artikel
Sprache:	eng
Schlagworte:	Calorimetry, Differential Scanning Crystallography, X-Ray Drug Discovery Drug Stability Humans Humidity hydrate inhibitor of apoptosis (IAP) protein Inhibitor of Apoptosis Proteins - antagonists & inhibitors Models, Molecular Oligopeptides - chemistry Phase Transition Pyrazines - chemistry Solubility T-3256336 Water - chemistry water activity
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