A Chimeric Cetuximab-Functionalized Corona as a Potent Delivery System for Microtubule-Destabilizing Nanocomplexes to Hepatocellular Carcinoma Cells: A Focus on EGFR and Tubulin Intracellular Dynamics

In this study, we have developed microtubule destabilizing agents combretastatin A4 (CA4) or 2-methoxyestradiol (2ME) encapsulated poly(d,l-lactide-co-glycolide)-b-poly(ethylene glycol) (PLGA-b-PEG) nanocomplexes for targeted delivery to human hepatocellular carcinoma (HCC) cells. An epidermal gro...

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Veröffentlicht in:	Molecular pharmaceutics 2015-11, Vol.12 (11), p.3908-3923
Hauptverfasser:	Poojari, Radhika, Kini, Sudarshan, Srivastava, Rohit, Panda, Dulal
Format:	Artikel
Sprache:	eng
Schlagworte:	Antineoplastic Agents - chemistry Antineoplastic Agents - pharmacology Apoptosis - drug effects Blotting, Western Carcinoma, Hepatocellular - drug therapy Carcinoma, Hepatocellular - metabolism Carcinoma, Hepatocellular - pathology Cell Movement - drug effects Cell Proliferation - drug effects Cetuximab - chemistry Cetuximab - pharmacology Drug Delivery Systems Fluorescent Antibody Technique Histones - metabolism Humans Liver Neoplasms - drug therapy Liver Neoplasms - metabolism Liver Neoplasms - pathology Microtubules Nanocomposites - chemistry Polyethylene Glycols - chemistry Polyglactin 910 - chemistry Receptor, Epidermal Growth Factor - metabolism Tubulin - metabolism Tumor Cells, Cultured
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