Structural covariance in schizophrenia and first-episode psychosis: An approach based on graph analysis
Abstract Schizophrenia is a neurodevelopmental disorder that produces abnormalities across different brain regions. Measuring structural covariance with MRI is a well-established approach to investigate common changes in distinct systems. We investigated structural covariance in schizophrenia in a l...
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| Veröffentlicht in: | Journal of psychiatric research 2015-12, Vol.71, p.89-96 |
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| creator | Zugman, André Assunção, Idaiane Vieira, Gilson Gadelha, Ary White, Thomas P Oliveira, Pedro Paulo M Noto, Cristiano Crossley, Nicolas Mcguire, Philip Cordeiro, Quirino Belangero, Sintia I.O Bressan, Rodrigo A Jackowski, Andrea P Sato, João Ricardo |
| description | Abstract Schizophrenia is a neurodevelopmental disorder that produces abnormalities across different brain regions. Measuring structural covariance with MRI is a well-established approach to investigate common changes in distinct systems. We investigated structural covariance in schizophrenia in a large Brazilian sample of individuals with chronic schizophrenia (n = 143), First Episode Psychosis (n = 32), and matched healthy controls (n = 82) using a combination of graph analysis and computational neuroanatomy. Firstly, we proposed the connectivity-closeness and integrity-closeness centrality measures and them compared healthy controls with chronic schizophrenia regarding these metrics. We then conducted a second analysis on the mapped regions comparing the pairwise difference between the three groups. Our results show that compared with controls, both patient groups (in pairwise comparisons) had a reduced integrity-closeness in pars orbitalis and insula, suggesting that the relationship between these areas and other brain regions is increased in schizophrenia. No differences were found between the First Episode Psychosis and Schizophrenia groups. Since in schizophrenia the brain is affected as a whole, this may mirror that these regions may be related to the generalized structural alteration seen in schizophrenia. |
| doi_str_mv | 10.1016/j.jpsychires.2015.09.018 |
| format | Article |
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Measuring structural covariance with MRI is a well-established approach to investigate common changes in distinct systems. We investigated structural covariance in schizophrenia in a large Brazilian sample of individuals with chronic schizophrenia (n = 143), First Episode Psychosis (n = 32), and matched healthy controls (n = 82) using a combination of graph analysis and computational neuroanatomy. Firstly, we proposed the connectivity-closeness and integrity-closeness centrality measures and them compared healthy controls with chronic schizophrenia regarding these metrics. We then conducted a second analysis on the mapped regions comparing the pairwise difference between the three groups. Our results show that compared with controls, both patient groups (in pairwise comparisons) had a reduced integrity-closeness in pars orbitalis and insula, suggesting that the relationship between these areas and other brain regions is increased in schizophrenia. No differences were found between the First Episode Psychosis and Schizophrenia groups. Since in schizophrenia the brain is affected as a whole, this may mirror that these regions may be related to the generalized structural alteration seen in schizophrenia.</description><identifier>ISSN: 0022-3956</identifier><identifier>EISSN: 1879-1379</identifier><identifier>DOI: 10.1016/j.jpsychires.2015.09.018</identifier><identifier>PMID: 26458012</identifier><language>eng</language><publisher>England: Elsevier Ltd</publisher><subject>Acute Disease ; Adult ; Brain - pathology ; Brazil ; Chronic Disease ; Female ; Graph analysis ; Humans ; Image Processing, Computer-Assisted - methods ; Magnetic Resonance Imaging - methods ; Male ; Neuroimaging ; Psychiatric Status Rating Scales ; Psychiatry ; Psychotic Disorders - pathology ; Schizophrenia ; Schizophrenia - pathology ; Structural covariance</subject><ispartof>Journal of psychiatric research, 2015-12, Vol.71, p.89-96</ispartof><rights>Elsevier Ltd</rights><rights>2015 Elsevier Ltd</rights><rights>Copyright © 2015 Elsevier Ltd. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c429t-e390e9c833ad42d98d18765f650642e766b0882d1a1a785df09658e65555dab3</citedby><cites>FETCH-LOGICAL-c429t-e390e9c833ad42d98d18765f650642e766b0882d1a1a785df09658e65555dab3</cites><orcidid>0000-0002-6126-7759</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.jpsychires.2015.09.018$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3548,27923,27924,45994</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26458012$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Zugman, André</creatorcontrib><creatorcontrib>Assunção, Idaiane</creatorcontrib><creatorcontrib>Vieira, Gilson</creatorcontrib><creatorcontrib>Gadelha, Ary</creatorcontrib><creatorcontrib>White, Thomas P</creatorcontrib><creatorcontrib>Oliveira, Pedro Paulo M</creatorcontrib><creatorcontrib>Noto, Cristiano</creatorcontrib><creatorcontrib>Crossley, Nicolas</creatorcontrib><creatorcontrib>Mcguire, Philip</creatorcontrib><creatorcontrib>Cordeiro, Quirino</creatorcontrib><creatorcontrib>Belangero, Sintia I.O</creatorcontrib><creatorcontrib>Bressan, Rodrigo A</creatorcontrib><creatorcontrib>Jackowski, Andrea P</creatorcontrib><creatorcontrib>Sato, João Ricardo</creatorcontrib><title>Structural covariance in schizophrenia and first-episode psychosis: An approach based on graph analysis</title><title>Journal of psychiatric research</title><addtitle>J Psychiatr Res</addtitle><description>Abstract Schizophrenia is a neurodevelopmental disorder that produces abnormalities across different brain regions. Measuring structural covariance with MRI is a well-established approach to investigate common changes in distinct systems. We investigated structural covariance in schizophrenia in a large Brazilian sample of individuals with chronic schizophrenia (n = 143), First Episode Psychosis (n = 32), and matched healthy controls (n = 82) using a combination of graph analysis and computational neuroanatomy. Firstly, we proposed the connectivity-closeness and integrity-closeness centrality measures and them compared healthy controls with chronic schizophrenia regarding these metrics. We then conducted a second analysis on the mapped regions comparing the pairwise difference between the three groups. Our results show that compared with controls, both patient groups (in pairwise comparisons) had a reduced integrity-closeness in pars orbitalis and insula, suggesting that the relationship between these areas and other brain regions is increased in schizophrenia. No differences were found between the First Episode Psychosis and Schizophrenia groups. Since in schizophrenia the brain is affected as a whole, this may mirror that these regions may be related to the generalized structural alteration seen in schizophrenia.</description><subject>Acute Disease</subject><subject>Adult</subject><subject>Brain - pathology</subject><subject>Brazil</subject><subject>Chronic Disease</subject><subject>Female</subject><subject>Graph analysis</subject><subject>Humans</subject><subject>Image Processing, Computer-Assisted - methods</subject><subject>Magnetic Resonance Imaging - methods</subject><subject>Male</subject><subject>Neuroimaging</subject><subject>Psychiatric Status Rating Scales</subject><subject>Psychiatry</subject><subject>Psychotic Disorders - pathology</subject><subject>Schizophrenia</subject><subject>Schizophrenia - pathology</subject><subject>Structural covariance</subject><issn>0022-3956</issn><issn>1879-1379</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkUFv1DAQhS0EokvhLyAfuSS1ndixOSCVCgpSJQ7t3fLak65DNg6epNLy6-tlC0ic8GV8ePNm3jeEUM5qzri6GOphxoPfxQxYC8ZlzUzNuH5GNlx3puJNZ56TDWNCVI2R6oy8QhwYY53g7UtyJlQrNeNiQ-5vl7z6Zc1upD49uBzd5IHGiWKx_5nmXYYpOuqmQPuYcalgjpgC0F8LJIz4nl5O1M1zTs7v6NYhBJomep_dvCt9bjwU0Wvyoncjwpunek7uPn-6u_pS3Xy7_np1eVP5Vphi3hgGxuumcaEVwehQ8ijZK8lUK6BTasu0FoE77jotQ8-MkhqULC-4bXNO3p1syzY_VsDF7iN6GEc3QVrR8k6YpjVC8CLVJ6nPCTFDb-cc9y4fLGf2SNkO9i9le6RsmbGFcml9-zRl3e4h_Gn8jbUIPp4EUKI-RMgWfYQCNhQvv9iQ4v9M-fCPiR_jFL0bv8MBcEhrLnBLJovCMnt7vPbx2FyWX2fa5hFIRKld</recordid><startdate>20151201</startdate><enddate>20151201</enddate><creator>Zugman, André</creator><creator>Assunção, Idaiane</creator><creator>Vieira, Gilson</creator><creator>Gadelha, Ary</creator><creator>White, Thomas P</creator><creator>Oliveira, Pedro Paulo M</creator><creator>Noto, Cristiano</creator><creator>Crossley, Nicolas</creator><creator>Mcguire, Philip</creator><creator>Cordeiro, Quirino</creator><creator>Belangero, Sintia I.O</creator><creator>Bressan, Rodrigo A</creator><creator>Jackowski, Andrea P</creator><creator>Sato, João Ricardo</creator><general>Elsevier Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-6126-7759</orcidid></search><sort><creationdate>20151201</creationdate><title>Structural covariance in schizophrenia and first-episode psychosis: An approach based on graph analysis</title><author>Zugman, André ; Assunção, Idaiane ; Vieira, Gilson ; Gadelha, Ary ; White, Thomas P ; Oliveira, Pedro Paulo M ; Noto, Cristiano ; Crossley, Nicolas ; Mcguire, Philip ; Cordeiro, Quirino ; Belangero, Sintia I.O ; Bressan, Rodrigo A ; Jackowski, Andrea P ; Sato, João Ricardo</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c429t-e390e9c833ad42d98d18765f650642e766b0882d1a1a785df09658e65555dab3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Acute Disease</topic><topic>Adult</topic><topic>Brain - pathology</topic><topic>Brazil</topic><topic>Chronic Disease</topic><topic>Female</topic><topic>Graph analysis</topic><topic>Humans</topic><topic>Image Processing, Computer-Assisted - methods</topic><topic>Magnetic Resonance Imaging - methods</topic><topic>Male</topic><topic>Neuroimaging</topic><topic>Psychiatric Status Rating Scales</topic><topic>Psychiatry</topic><topic>Psychotic Disorders - pathology</topic><topic>Schizophrenia</topic><topic>Schizophrenia - pathology</topic><topic>Structural covariance</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Zugman, André</creatorcontrib><creatorcontrib>Assunção, Idaiane</creatorcontrib><creatorcontrib>Vieira, Gilson</creatorcontrib><creatorcontrib>Gadelha, Ary</creatorcontrib><creatorcontrib>White, Thomas P</creatorcontrib><creatorcontrib>Oliveira, Pedro Paulo M</creatorcontrib><creatorcontrib>Noto, Cristiano</creatorcontrib><creatorcontrib>Crossley, Nicolas</creatorcontrib><creatorcontrib>Mcguire, Philip</creatorcontrib><creatorcontrib>Cordeiro, Quirino</creatorcontrib><creatorcontrib>Belangero, Sintia I.O</creatorcontrib><creatorcontrib>Bressan, Rodrigo A</creatorcontrib><creatorcontrib>Jackowski, Andrea P</creatorcontrib><creatorcontrib>Sato, João Ricardo</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of psychiatric research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zugman, André</au><au>Assunção, Idaiane</au><au>Vieira, Gilson</au><au>Gadelha, Ary</au><au>White, Thomas P</au><au>Oliveira, Pedro Paulo M</au><au>Noto, Cristiano</au><au>Crossley, Nicolas</au><au>Mcguire, Philip</au><au>Cordeiro, Quirino</au><au>Belangero, Sintia I.O</au><au>Bressan, Rodrigo A</au><au>Jackowski, Andrea P</au><au>Sato, João Ricardo</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Structural covariance in schizophrenia and first-episode psychosis: An approach based on graph analysis</atitle><jtitle>Journal of psychiatric research</jtitle><addtitle>J Psychiatr Res</addtitle><date>2015-12-01</date><risdate>2015</risdate><volume>71</volume><spage>89</spage><epage>96</epage><pages>89-96</pages><issn>0022-3956</issn><eissn>1879-1379</eissn><abstract>Abstract Schizophrenia is a neurodevelopmental disorder that produces abnormalities across different brain regions. Measuring structural covariance with MRI is a well-established approach to investigate common changes in distinct systems. We investigated structural covariance in schizophrenia in a large Brazilian sample of individuals with chronic schizophrenia (n = 143), First Episode Psychosis (n = 32), and matched healthy controls (n = 82) using a combination of graph analysis and computational neuroanatomy. Firstly, we proposed the connectivity-closeness and integrity-closeness centrality measures and them compared healthy controls with chronic schizophrenia regarding these metrics. We then conducted a second analysis on the mapped regions comparing the pairwise difference between the three groups. Our results show that compared with controls, both patient groups (in pairwise comparisons) had a reduced integrity-closeness in pars orbitalis and insula, suggesting that the relationship between these areas and other brain regions is increased in schizophrenia. 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| ispartof | Journal of psychiatric research, 2015-12, Vol.71, p.89-96 |
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| subjects | Acute Disease Adult Brain - pathology Brazil Chronic Disease Female Graph analysis Humans Image Processing, Computer-Assisted - methods Magnetic Resonance Imaging - methods Male Neuroimaging Psychiatric Status Rating Scales Psychiatry Psychotic Disorders - pathology Schizophrenia Schizophrenia - pathology Structural covariance |
| title | Structural covariance in schizophrenia and first-episode psychosis: An approach based on graph analysis |
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