Pharmacokinetics of meglumine antimoniate after administration of a multiple dose in dogs experimentally infected with Leishmania infantum

Pharmacokinetics of meglumine antimoniate in dogs with experimentally induced leishmaniosis has been investigated. After infection, dogs received a dose of 75 mg kg −1 of meglumine antimoniate twice daily by subcutaneous injection for 10 days. Blood samples were collected throughout the treatment. N...

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Veröffentlicht in:	Veterinary parasitology 1998-02, Vol.75 (1), p.33-40
Hauptverfasser:	Valladares, Josep-Enric, Riera, Cristina, Alberola, Jordi, Gállego, Montserrat, Portús, Montserrat, Cristòfol, Carles, Franquelo, Carme, Arboix, Margarita
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis of Variance Animals Antibodies, Protozoan - blood Antiprotozoal Agents - administration & dosage Antiprotozoal Agents - pharmacokinetics Antiprotozoal Agents - therapeutic use Control methods—Protozoa Dog Dog Diseases Dogs Drug Administration Schedule Injections, Subcutaneous Leishmania infantum Leishmaniasis, Visceral - blood Leishmaniasis, Visceral - drug therapy Leishmaniasis, Visceral - veterinary Male Meglumine - administration & dosage Meglumine - pharmacokinetics Meglumine - therapeutic use Meglumine Antimoniate Metabolic Clearance Rate Organometallic Compounds - administration & dosage Organometallic Compounds - pharmacokinetics Organometallic Compounds - therapeutic use Pharmacokinetics
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