Cell death in the rat hippocampus in a model of prenatal brain injury: time course and expression of death-related proteins

Survival rates have increased dramatically for very premature (gestational week 24–28) infants. However, many of these infants grow up to have profound cognitive, motor and behavioral impairments due to brain damage. We have developed a novel model of prenatal infant gray matter injury. During the n...

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Veröffentlicht in:	Neuroscience 2004, Vol.129 (2), p.393-402
Hauptverfasser:	Nuñez, J.L., McCarthy, M.M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Animals, Newborn Apoptosis - physiology bax bcl-2 bcl-2-Associated X Protein Biological and medical sciences Blotting, Western Brain Damage, Chronic - etiology Brain Damage, Chronic - metabolism Brain Damage, Chronic - pathology Caspase 9 Caspases - biosynthesis Cell Death - physiology Dentate Gyrus - pathology Fetal Diseases - metabolism Fetal Diseases - pathology Fundamental and applied biological sciences. Psychology GABA GABA Agonists - pharmacology GABA Agonists - toxicity GABA-A Receptor Agonists Hippocampus - pathology Immunohistochemistry In Situ Nick-End Labeling Muscimol - pharmacology Muscimol - toxicity Necrosis - pathology Nerve Tissue Proteins - metabolism Proto-Oncogene Proteins c-bcl-2 - biosynthesis Rats Rats, Sprague-Dawley Vertebrates: nervous system and sense organs
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