Chronic toxicity of diethylenetriamine pentaacetic acid to crimson-spotted rainbowfish (Melanotaenia fluviatilis) : Effects on reproduction, condition, and ethoxyresorufin O-deethylase activity
The chronic effects of the chelating agent diethylenetriamine pentaacetic acid (DTPA) on reproduction, condition factor, liver somatic index (LSI), gonad somatic index (GSI), and ethoxyresorufin O-deethylase (EROD) activity of adult Australian crimson-spotted rainbowfish (Melanotaenia fluviatilis) w...
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| Veröffentlicht in: | Ecotoxicology and environmental safety 1999-05, Vol.43 (1), p.74-82 |
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| description | The chronic effects of the chelating agent diethylenetriamine pentaacetic acid (DTPA) on reproduction, condition factor, liver somatic index (LSI), gonad somatic index (GSI), and ethoxyresorufin O-deethylase (EROD) activity of adult Australian crimson-spotted rainbowfish (Melanotaenia fluviatilis) were assessed. Breeding groups of three females and two males were exposed to 0, 1, 10, or 100 mg/liter DTPA (nominal) in a 28-day "static-renewal" experiment. Overall, the toxicity of DTPA to adult crimson-spotted rainbowfish was relatively low. Reproduction was not affected at concentrations up to 100 mg/liter DTPA, although an early effect on hatchability was potentially attributed to direct toxicity to rainbowfish eggs. DTPA also had little effect on the condition of adult rainbowfish, with condition factor and GSI being unaffected at concentrations up to 100 mg/liter, the latter finding supporting the reproduction results. However, LSI in male rainbowfish exposed to 100 mg/liter was significantly lower than in those exposed to 1 mg/liter DTPA (P |
| doi_str_mv | 10.1006/eesa.1999.1768 |
| format | Article |
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A ; AHOKAS, J. T ; HOLDWAY, D. A</creator><creatorcontrib>VAN DAM, R. A ; AHOKAS, J. T ; HOLDWAY, D. A</creatorcontrib><description>The chronic effects of the chelating agent diethylenetriamine pentaacetic acid (DTPA) on reproduction, condition factor, liver somatic index (LSI), gonad somatic index (GSI), and ethoxyresorufin O-deethylase (EROD) activity of adult Australian crimson-spotted rainbowfish (Melanotaenia fluviatilis) were assessed. Breeding groups of three females and two males were exposed to 0, 1, 10, or 100 mg/liter DTPA (nominal) in a 28-day "static-renewal" experiment. Overall, the toxicity of DTPA to adult crimson-spotted rainbowfish was relatively low. Reproduction was not affected at concentrations up to 100 mg/liter DTPA, although an early effect on hatchability was potentially attributed to direct toxicity to rainbowfish eggs. DTPA also had little effect on the condition of adult rainbowfish, with condition factor and GSI being unaffected at concentrations up to 100 mg/liter, the latter finding supporting the reproduction results. However, LSI in male rainbowfish exposed to 100 mg/liter was significantly lower than in those exposed to 1 mg/liter DTPA (P</=0.05), but not controls. LSI was not affected in female rainbowfish. The major effect of exposure to DTPA was an approximate 50% inhibition of EROD activity in female rainbowfish exposed to 100 mg/liter DTPA (mean+/-SE: 6.39+/-1.56 pmol/min/mg protein) compared with controls (12.29+/-1.80 pmol/min/mg protein; P</=0.05). DTPA had no effect on EROD activity in male rainbowfish. The apparent inhibition of EROD by DTPA appears to be the first such effect of a chelating agent to be reported in the external literature, and may have consequences for aquatic organisms exposed to multiple-contaminant situations. However, the concentration of DTPA required to produce inhibition of EROD activity (i.e., 100 mg/liter) is not likely to occur in Australian aquatic environments, and thus the risk to fish appears minimal. The lowest-observed-effect and no-observed-effect concentrations of DTPA (nominal) for adult crimson-spotted rainbowfish were 100 and 10 mg/liter, respectively.</description><identifier>ISSN: 0147-6513</identifier><identifier>EISSN: 1090-2414</identifier><identifier>DOI: 10.1006/eesa.1999.1768</identifier><identifier>PMID: 10330324</identifier><identifier>CODEN: EESADV</identifier><language>eng</language><publisher>San Diego, CA: Elsevier</publisher><subject>Agnatha. Pisces ; Animal, plant and microbial ecology ; Animals ; Applied ecology ; Biological and medical sciences ; Chelating Agents - toxicity ; Cytochrome P-450 CYP1A1 - metabolism ; Ecotoxicology, biological effects of pollution ; Effects of pollution and side effects of pesticides on vertebrates ; Female ; Fishes - metabolism ; Fishes - physiology ; Fundamental and applied biological sciences. Psychology ; Gonads - anatomy & histology ; Gonads - drug effects ; Liver - anatomy & histology ; Liver - drug effects ; Male ; Melanotaenia fluviatilis ; Organ Size - drug effects ; Ovum - drug effects ; Pentetic Acid - toxicity ; Reproduction - drug effects ; Time Factors</subject><ispartof>Ecotoxicology and environmental safety, 1999-05, Vol.43 (1), p.74-82</ispartof><rights>1999 INIST-CNRS</rights><rights>Copyright 1999 Academic Press.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27923,27924</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1878257$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10330324$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>VAN DAM, R. A</creatorcontrib><creatorcontrib>AHOKAS, J. T</creatorcontrib><creatorcontrib>HOLDWAY, D. A</creatorcontrib><title>Chronic toxicity of diethylenetriamine pentaacetic acid to crimson-spotted rainbowfish (Melanotaenia fluviatilis) : Effects on reproduction, condition, and ethoxyresorufin O-deethylase activity</title><title>Ecotoxicology and environmental safety</title><addtitle>Ecotoxicol Environ Saf</addtitle><description>The chronic effects of the chelating agent diethylenetriamine pentaacetic acid (DTPA) on reproduction, condition factor, liver somatic index (LSI), gonad somatic index (GSI), and ethoxyresorufin O-deethylase (EROD) activity of adult Australian crimson-spotted rainbowfish (Melanotaenia fluviatilis) were assessed. Breeding groups of three females and two males were exposed to 0, 1, 10, or 100 mg/liter DTPA (nominal) in a 28-day "static-renewal" experiment. Overall, the toxicity of DTPA to adult crimson-spotted rainbowfish was relatively low. Reproduction was not affected at concentrations up to 100 mg/liter DTPA, although an early effect on hatchability was potentially attributed to direct toxicity to rainbowfish eggs. DTPA also had little effect on the condition of adult rainbowfish, with condition factor and GSI being unaffected at concentrations up to 100 mg/liter, the latter finding supporting the reproduction results. However, LSI in male rainbowfish exposed to 100 mg/liter was significantly lower than in those exposed to 1 mg/liter DTPA (P</=0.05), but not controls. LSI was not affected in female rainbowfish. The major effect of exposure to DTPA was an approximate 50% inhibition of EROD activity in female rainbowfish exposed to 100 mg/liter DTPA (mean+/-SE: 6.39+/-1.56 pmol/min/mg protein) compared with controls (12.29+/-1.80 pmol/min/mg protein; P</=0.05). DTPA had no effect on EROD activity in male rainbowfish. The apparent inhibition of EROD by DTPA appears to be the first such effect of a chelating agent to be reported in the external literature, and may have consequences for aquatic organisms exposed to multiple-contaminant situations. However, the concentration of DTPA required to produce inhibition of EROD activity (i.e., 100 mg/liter) is not likely to occur in Australian aquatic environments, and thus the risk to fish appears minimal. The lowest-observed-effect and no-observed-effect concentrations of DTPA (nominal) for adult crimson-spotted rainbowfish were 100 and 10 mg/liter, respectively.</description><subject>Agnatha. Pisces</subject><subject>Animal, plant and microbial ecology</subject><subject>Animals</subject><subject>Applied ecology</subject><subject>Biological and medical sciences</subject><subject>Chelating Agents - toxicity</subject><subject>Cytochrome P-450 CYP1A1 - metabolism</subject><subject>Ecotoxicology, biological effects of pollution</subject><subject>Effects of pollution and side effects of pesticides on vertebrates</subject><subject>Female</subject><subject>Fishes - metabolism</subject><subject>Fishes - physiology</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Gonads - anatomy & histology</subject><subject>Gonads - drug effects</subject><subject>Liver - anatomy & histology</subject><subject>Liver - drug effects</subject><subject>Male</subject><subject>Melanotaenia fluviatilis</subject><subject>Organ Size - drug effects</subject><subject>Ovum - drug effects</subject><subject>Pentetic Acid - toxicity</subject><subject>Reproduction - drug effects</subject><subject>Time Factors</subject><issn>0147-6513</issn><issn>1090-2414</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1999</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqF0T1vFDEQgGELgcgl0FIiFwgFiT38sd5d06FT-JCC0kB9mvWOdYP27MP2htzP459hkUOUqezi0ei1h7EXUqylEN07xAxraa1dy74bHrGVFFY0qpXtY7YSsu2bzkh9xs5z_iGE0MKYp-xMCq2FVu2K_d7sUgzkeIl35KgcefR8Iiy744wBSyLYU0B-wFAAHJZKwdFUPXeJ9jmGJh9iKTjxBBTG-MtT3vHLrzhDiAUwEHA_L7cEhWbKb_h7fuU9upJ5DDzhIcVpcYVieMtdDBPdXyFMvFbEu2PCHNPiKfCbZsK_ZZCxVhS6rcHP2BMPc8bnp_OCff949W3zubm--fRl8-G6OWhlS2MlKDe0MBo0QrWjHbz33SCUMrr1esS-leiElLpTTtjRWIPge4mgvZe90hfs9f3cGvxzwVy2e8oO5_pMjEveVmOlEuZh2BopreofhroTdXmiwpcnuIx7nLaH-vGQjtt_a6zg1QlAdjD7BMFR_u-GflCm138AI16xGg</recordid><startdate>19990501</startdate><enddate>19990501</enddate><creator>VAN DAM, R. A</creator><creator>AHOKAS, J. T</creator><creator>HOLDWAY, D. A</creator><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7QH</scope><scope>7ST</scope><scope>C1K</scope><scope>SOI</scope><scope>7TV</scope><scope>7U7</scope><scope>7UA</scope><scope>F1W</scope><scope>H97</scope><scope>L.G</scope></search><sort><creationdate>19990501</creationdate><title>Chronic toxicity of diethylenetriamine pentaacetic acid to crimson-spotted rainbowfish (Melanotaenia fluviatilis) : Effects on reproduction, condition, and ethoxyresorufin O-deethylase activity</title><author>VAN DAM, R. A ; AHOKAS, J. T ; HOLDWAY, D. A</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p329t-91a2c84ab5e5024b98fff68022534f3be741ec011362c09b595eaf71ea3ff1723</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1999</creationdate><topic>Agnatha. Pisces</topic><topic>Animal, plant and microbial ecology</topic><topic>Animals</topic><topic>Applied ecology</topic><topic>Biological and medical sciences</topic><topic>Chelating Agents - toxicity</topic><topic>Cytochrome P-450 CYP1A1 - metabolism</topic><topic>Ecotoxicology, biological effects of pollution</topic><topic>Effects of pollution and side effects of pesticides on vertebrates</topic><topic>Female</topic><topic>Fishes - metabolism</topic><topic>Fishes - physiology</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Gonads - anatomy & histology</topic><topic>Gonads - drug effects</topic><topic>Liver - anatomy & histology</topic><topic>Liver - drug effects</topic><topic>Male</topic><topic>Melanotaenia fluviatilis</topic><topic>Organ Size - drug effects</topic><topic>Ovum - drug effects</topic><topic>Pentetic Acid - toxicity</topic><topic>Reproduction - drug effects</topic><topic>Time Factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>VAN DAM, R. A</creatorcontrib><creatorcontrib>AHOKAS, J. T</creatorcontrib><creatorcontrib>HOLDWAY, D. A</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>Aqualine</collection><collection>Environment Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Environment Abstracts</collection><collection>Pollution Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Water Resources Abstracts</collection><collection>ASFA: Aquatic Sciences and Fisheries Abstracts</collection><collection>Aquatic Science & Fisheries Abstracts (ASFA) 3: Aquatic Pollution & Environmental Quality</collection><collection>Aquatic Science & Fisheries Abstracts (ASFA) Professional</collection><jtitle>Ecotoxicology and environmental safety</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>VAN DAM, R. A</au><au>AHOKAS, J. T</au><au>HOLDWAY, D. A</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Chronic toxicity of diethylenetriamine pentaacetic acid to crimson-spotted rainbowfish (Melanotaenia fluviatilis) : Effects on reproduction, condition, and ethoxyresorufin O-deethylase activity</atitle><jtitle>Ecotoxicology and environmental safety</jtitle><addtitle>Ecotoxicol Environ Saf</addtitle><date>1999-05-01</date><risdate>1999</risdate><volume>43</volume><issue>1</issue><spage>74</spage><epage>82</epage><pages>74-82</pages><issn>0147-6513</issn><eissn>1090-2414</eissn><coden>EESADV</coden><abstract>The chronic effects of the chelating agent diethylenetriamine pentaacetic acid (DTPA) on reproduction, condition factor, liver somatic index (LSI), gonad somatic index (GSI), and ethoxyresorufin O-deethylase (EROD) activity of adult Australian crimson-spotted rainbowfish (Melanotaenia fluviatilis) were assessed. Breeding groups of three females and two males were exposed to 0, 1, 10, or 100 mg/liter DTPA (nominal) in a 28-day "static-renewal" experiment. Overall, the toxicity of DTPA to adult crimson-spotted rainbowfish was relatively low. Reproduction was not affected at concentrations up to 100 mg/liter DTPA, although an early effect on hatchability was potentially attributed to direct toxicity to rainbowfish eggs. DTPA also had little effect on the condition of adult rainbowfish, with condition factor and GSI being unaffected at concentrations up to 100 mg/liter, the latter finding supporting the reproduction results. However, LSI in male rainbowfish exposed to 100 mg/liter was significantly lower than in those exposed to 1 mg/liter DTPA (P</=0.05), but not controls. LSI was not affected in female rainbowfish. The major effect of exposure to DTPA was an approximate 50% inhibition of EROD activity in female rainbowfish exposed to 100 mg/liter DTPA (mean+/-SE: 6.39+/-1.56 pmol/min/mg protein) compared with controls (12.29+/-1.80 pmol/min/mg protein; P</=0.05). DTPA had no effect on EROD activity in male rainbowfish. The apparent inhibition of EROD by DTPA appears to be the first such effect of a chelating agent to be reported in the external literature, and may have consequences for aquatic organisms exposed to multiple-contaminant situations. However, the concentration of DTPA required to produce inhibition of EROD activity (i.e., 100 mg/liter) is not likely to occur in Australian aquatic environments, and thus the risk to fish appears minimal. The lowest-observed-effect and no-observed-effect concentrations of DTPA (nominal) for adult crimson-spotted rainbowfish were 100 and 10 mg/liter, respectively.</abstract><cop>San Diego, CA</cop><pub>Elsevier</pub><pmid>10330324</pmid><doi>10.1006/eesa.1999.1768</doi><tpages>9</tpages></addata></record> |
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| ispartof | Ecotoxicology and environmental safety, 1999-05, Vol.43 (1), p.74-82 |
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| language | eng |
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| source | MEDLINE; ScienceDirect Journals (5 years ago - present) |
| subjects | Agnatha. Pisces Animal, plant and microbial ecology Animals Applied ecology Biological and medical sciences Chelating Agents - toxicity Cytochrome P-450 CYP1A1 - metabolism Ecotoxicology, biological effects of pollution Effects of pollution and side effects of pesticides on vertebrates Female Fishes - metabolism Fishes - physiology Fundamental and applied biological sciences. Psychology Gonads - anatomy & histology Gonads - drug effects Liver - anatomy & histology Liver - drug effects Male Melanotaenia fluviatilis Organ Size - drug effects Ovum - drug effects Pentetic Acid - toxicity Reproduction - drug effects Time Factors |
| title | Chronic toxicity of diethylenetriamine pentaacetic acid to crimson-spotted rainbowfish (Melanotaenia fluviatilis) : Effects on reproduction, condition, and ethoxyresorufin O-deethylase activity |
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