Retinoic acid induces macrophage cholesterol efflux and inhibits atherosclerotic plaque formation in apoE-deficient mice

It has been suggested that retinoic acid (RA) has a potential role in the prevention of atherosclerotic CVD. In the present study, we used J774A.1 cell lines and primary peritoneal macrophages to investigate the protective effects of RA on foam cell formation and atherogenesis in apoE-deficient (apo...

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Veröffentlicht in:	British journal of nutrition 2015-08, Vol.114 (4), p.509-518
Hauptverfasser:	Zhou, Wenjing, Lin, Jiacheng, Chen, Hongen, Wang, Jingjing, Liu, Yan, Xia, Min
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Aorta Apolipoproteins E - genetics Apolipoproteins E - metabolism Atherosclerosis Atherosclerosis - metabolism Atherosclerosis - pathology Atherosclerosis - prevention & control ATP Binding Cassette Transporter 1 - metabolism Cell Line Cholesterol Cholesterol - metabolism Cholesterol, LDL - blood Diet, High-Fat Foam Cells - metabolism Lipoproteins, LDL - metabolism Liver X Receptors Macrophages, Peritoneal - drug effects Macrophages, Peritoneal - metabolism Male Mice, Knockout Molecular Nutrition Orphan Nuclear Receptors - metabolism Plaque, Atherosclerotic - metabolism Plaque, Atherosclerotic - prevention & control Rodents Tretinoin - pharmacology Tretinoin - therapeutic use Up-Regulation Vitamin A
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