Acute Myelogenous Leukemia with Cuplike Nuclei
Based on the morphology of the blasts, it is difficult to determine cell lineage. [...]we performed immunophenotyping by flow cytometry on the peripheral blood specimen. A high correlation of cuplike nuclei and NPM1 mutation has been demonstrated by various studies.11-13 NPM1 mutations are further a...
Gespeichert in:
| Veröffentlicht in: | Laboratory medicine 2015-11, Vol.46 (4), p.e93-e97 |
|---|---|
| Hauptverfasser: | , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | e97 |
|---|---|
| container_issue | 4 |
| container_start_page | e93 |
| container_title | Laboratory medicine |
| container_volume | 46 |
| creator | Robinson, Erica Van Siclen, Carleen |
| description | Based on the morphology of the blasts, it is difficult to determine cell lineage. [...]we performed immunophenotyping by flow cytometry on the peripheral blood specimen. A high correlation of cuplike nuclei and NPM1 mutation has been demonstrated by various studies.11-13 NPM1 mutations are further associated with a normal karyotype, an internal tandem duplication of the FLT3 gene, a higher white blood cell (WBC) count in the peripheral blood, a higher fraction of blasts in the bone marrow, lower expression of CD34 antigen, and female sex.4,9 Many of these characteristics are similar to our patient's leukemic expression. |
| doi_str_mv | 10.1309/LMXC433INJAYLSTD |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1728675172</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><oup_id>10.1309/LMXC433INJAYLSTD</oup_id><sourcerecordid>3930490021</sourcerecordid><originalsourceid>FETCH-LOGICAL-c405t-d6e5857cbc260b5866c6ab4bb76bb886fec5aebe6f9dec0bffef2378e8f9d3093</originalsourceid><addsrcrecordid>eNqFkM1Lw0AQxRdRbK3ePUnAiyCpu0n2I8cSvyppPVhBTyG7ndW0SROzWaT_vVtaPfTiaZjh9x5vHkLnBA9JiOObdPKWRGE4nj6N3tOX2e0B6pM4Cn3OQ3yI-hhj7lMc8B46MWbh1ihmwTHqBYySAMesj4YjZTvwJmso6w9Y1dZ4KdglVEXufRfdp5fYpiyW4E2tKqE4RUc6Lw2c7eYAvd7fzZJHP31-GCej1FcRpp0_Z0AF5UqqgGFJBWOK5TKSkjMphWAaFM1BAtPxHBSWWoMOQi5AuIN7LBygq61v09ZfFkyXVYVRUJb5ClzGjPBAME7dcOjlHrqobbty6RxFY8IJ4RtDvKVUWxvTgs6atqjydp0RnG26zPa7dJKLnbGVFcz_BL_lOeB6C9S2-d_uB5xffWw</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1759171179</pqid></control><display><type>article</type><title>Acute Myelogenous Leukemia with Cuplike Nuclei</title><source>MEDLINE</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>Oxford University Press Journals All Titles (1996-Current)</source><source>Alma/SFX Local Collection</source><creator>Robinson, Erica ; Van Siclen, Carleen</creator><creatorcontrib>Robinson, Erica ; Van Siclen, Carleen</creatorcontrib><description>Based on the morphology of the blasts, it is difficult to determine cell lineage. [...]we performed immunophenotyping by flow cytometry on the peripheral blood specimen. A high correlation of cuplike nuclei and NPM1 mutation has been demonstrated by various studies.11-13 NPM1 mutations are further associated with a normal karyotype, an internal tandem duplication of the FLT3 gene, a higher white blood cell (WBC) count in the peripheral blood, a higher fraction of blasts in the bone marrow, lower expression of CD34 antigen, and female sex.4,9 Many of these characteristics are similar to our patient's leukemic expression.</description><identifier>ISSN: 0007-5027</identifier><identifier>EISSN: 1943-7730</identifier><identifier>DOI: 10.1309/LMXC433INJAYLSTD</identifier><identifier>PMID: 26512096</identifier><language>eng</language><publisher>Oxford, UK: Oxford University Press</publisher><subject>Aged ; Antigens ; Biopsy ; Blood ; Bone marrow ; Cell cycle ; Cell Nucleus - pathology ; Classification ; Diagnosis, Differential ; Flow Cytometry ; Genes ; Humans ; Kinases ; Laboratories ; Leukemia ; Leukemia, Myeloid, Acute - diagnosis ; Leukemia, Myeloid, Acute - genetics ; Leukemia, Myeloid, Acute - pathology ; Leukemia, Myeloid, Acute - physiopathology ; Male ; Morphology ; Mutation ; Patients</subject><ispartof>Laboratory medicine, 2015-11, Vol.46 (4), p.e93-e97</ispartof><rights>American Society of Clinical Pathologists 2015</rights><rights>Copyright American Society for Clinical Pathology Fall 2015</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c405t-d6e5857cbc260b5866c6ab4bb76bb886fec5aebe6f9dec0bffef2378e8f9d3093</citedby><cites>FETCH-LOGICAL-c405t-d6e5857cbc260b5866c6ab4bb76bb886fec5aebe6f9dec0bffef2378e8f9d3093</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26512096$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Robinson, Erica</creatorcontrib><creatorcontrib>Van Siclen, Carleen</creatorcontrib><title>Acute Myelogenous Leukemia with Cuplike Nuclei</title><title>Laboratory medicine</title><addtitle>Lab Med</addtitle><description>Based on the morphology of the blasts, it is difficult to determine cell lineage. [...]we performed immunophenotyping by flow cytometry on the peripheral blood specimen. A high correlation of cuplike nuclei and NPM1 mutation has been demonstrated by various studies.11-13 NPM1 mutations are further associated with a normal karyotype, an internal tandem duplication of the FLT3 gene, a higher white blood cell (WBC) count in the peripheral blood, a higher fraction of blasts in the bone marrow, lower expression of CD34 antigen, and female sex.4,9 Many of these characteristics are similar to our patient's leukemic expression.</description><subject>Aged</subject><subject>Antigens</subject><subject>Biopsy</subject><subject>Blood</subject><subject>Bone marrow</subject><subject>Cell cycle</subject><subject>Cell Nucleus - pathology</subject><subject>Classification</subject><subject>Diagnosis, Differential</subject><subject>Flow Cytometry</subject><subject>Genes</subject><subject>Humans</subject><subject>Kinases</subject><subject>Laboratories</subject><subject>Leukemia</subject><subject>Leukemia, Myeloid, Acute - diagnosis</subject><subject>Leukemia, Myeloid, Acute - genetics</subject><subject>Leukemia, Myeloid, Acute - pathology</subject><subject>Leukemia, Myeloid, Acute - physiopathology</subject><subject>Male</subject><subject>Morphology</subject><subject>Mutation</subject><subject>Patients</subject><issn>0007-5027</issn><issn>1943-7730</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNqFkM1Lw0AQxRdRbK3ePUnAiyCpu0n2I8cSvyppPVhBTyG7ndW0SROzWaT_vVtaPfTiaZjh9x5vHkLnBA9JiOObdPKWRGE4nj6N3tOX2e0B6pM4Cn3OQ3yI-hhj7lMc8B46MWbh1ihmwTHqBYySAMesj4YjZTvwJmso6w9Y1dZ4KdglVEXufRfdp5fYpiyW4E2tKqE4RUc6Lw2c7eYAvd7fzZJHP31-GCej1FcRpp0_Z0AF5UqqgGFJBWOK5TKSkjMphWAaFM1BAtPxHBSWWoMOQi5AuIN7LBygq61v09ZfFkyXVYVRUJb5ClzGjPBAME7dcOjlHrqobbty6RxFY8IJ4RtDvKVUWxvTgs6atqjydp0RnG26zPa7dJKLnbGVFcz_BL_lOeB6C9S2-d_uB5xffWw</recordid><startdate>20151101</startdate><enddate>20151101</enddate><creator>Robinson, Erica</creator><creator>Van Siclen, Carleen</creator><general>Oxford University Press</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8C1</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>M1P</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>20151101</creationdate><title>Acute Myelogenous Leukemia with Cuplike Nuclei</title><author>Robinson, Erica ; Van Siclen, Carleen</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c405t-d6e5857cbc260b5866c6ab4bb76bb886fec5aebe6f9dec0bffef2378e8f9d3093</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Aged</topic><topic>Antigens</topic><topic>Biopsy</topic><topic>Blood</topic><topic>Bone marrow</topic><topic>Cell cycle</topic><topic>Cell Nucleus - pathology</topic><topic>Classification</topic><topic>Diagnosis, Differential</topic><topic>Flow Cytometry</topic><topic>Genes</topic><topic>Humans</topic><topic>Kinases</topic><topic>Laboratories</topic><topic>Leukemia</topic><topic>Leukemia, Myeloid, Acute - diagnosis</topic><topic>Leukemia, Myeloid, Acute - genetics</topic><topic>Leukemia, Myeloid, Acute - pathology</topic><topic>Leukemia, Myeloid, Acute - physiopathology</topic><topic>Male</topic><topic>Morphology</topic><topic>Mutation</topic><topic>Patients</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Robinson, Erica</creatorcontrib><creatorcontrib>Van Siclen, Carleen</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Public Health Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>Laboratory medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Robinson, Erica</au><au>Van Siclen, Carleen</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Acute Myelogenous Leukemia with Cuplike Nuclei</atitle><jtitle>Laboratory medicine</jtitle><addtitle>Lab Med</addtitle><date>2015-11-01</date><risdate>2015</risdate><volume>46</volume><issue>4</issue><spage>e93</spage><epage>e97</epage><pages>e93-e97</pages><issn>0007-5027</issn><eissn>1943-7730</eissn><abstract>Based on the morphology of the blasts, it is difficult to determine cell lineage. [...]we performed immunophenotyping by flow cytometry on the peripheral blood specimen. A high correlation of cuplike nuclei and NPM1 mutation has been demonstrated by various studies.11-13 NPM1 mutations are further associated with a normal karyotype, an internal tandem duplication of the FLT3 gene, a higher white blood cell (WBC) count in the peripheral blood, a higher fraction of blasts in the bone marrow, lower expression of CD34 antigen, and female sex.4,9 Many of these characteristics are similar to our patient's leukemic expression.</abstract><cop>Oxford, UK</cop><pub>Oxford University Press</pub><pmid>26512096</pmid><doi>10.1309/LMXC433INJAYLSTD</doi><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0007-5027 |
| ispartof | Laboratory medicine, 2015-11, Vol.46 (4), p.e93-e97 |
| issn | 0007-5027 1943-7730 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1728675172 |
| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Oxford University Press Journals All Titles (1996-Current); Alma/SFX Local Collection |
| subjects | Aged Antigens Biopsy Blood Bone marrow Cell cycle Cell Nucleus - pathology Classification Diagnosis, Differential Flow Cytometry Genes Humans Kinases Laboratories Leukemia Leukemia, Myeloid, Acute - diagnosis Leukemia, Myeloid, Acute - genetics Leukemia, Myeloid, Acute - pathology Leukemia, Myeloid, Acute - physiopathology Male Morphology Mutation Patients |
| title | Acute Myelogenous Leukemia with Cuplike Nuclei |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-29T17%3A49%3A29IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Acute%20Myelogenous%20Leukemia%20with%20Cuplike%20Nuclei&rft.jtitle=Laboratory%20medicine&rft.au=Robinson,%20Erica&rft.date=2015-11-01&rft.volume=46&rft.issue=4&rft.spage=e93&rft.epage=e97&rft.pages=e93-e97&rft.issn=0007-5027&rft.eissn=1943-7730&rft_id=info:doi/10.1309/LMXC433INJAYLSTD&rft_dat=%3Cproquest_cross%3E3930490021%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1759171179&rft_id=info:pmid/26512096&rft_oup_id=10.1309/LMXC433INJAYLSTD&rfr_iscdi=true |