Exosomes derived from miR-122-modified adipose tissue-derived MSCs increase chemosensitivity of hepatocellular carcinoma

Hepatocellular carcinoma (HCC) displays high resistance to conventional chemotherapy. Considering that microRNA-122 (miR-122) performs an essential function to promote chemosensitivity of HCC cells, an effective vehicle-mediated miR-122 delivery may represent a promising strategy for HCC chemotherap...

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Veröffentlicht in:	Journal of hematology and oncology 2015-10, Vol.8, p.122-122
Hauptverfasser:	Lou, Guohua, Song, Xiuli, Yang, Fan, Wu, Shanshan, Wang, Jing, Chen, Zhi, Liu, Yanning
Format:	Artikel
Sprache:	eng
Schlagworte:	Adipose Tissue - cytology Adult Animals Antineoplastic Agents - pharmacology Apoptosis Apoptosis - drug effects Apoptosis - genetics Blotting, Western Body fat Carcinoma, Hepatocellular - drug therapy Carcinoma, Hepatocellular - genetics Carcinoma, Hepatocellular - pathology Cell cycle Cell Survival - drug effects Cell Survival - genetics Exosomes - genetics Female Gene Expression Regulation, Neoplastic - drug effects Gene Expression Regulation, Neoplastic - genetics Genes Hematology Hep G2 Cells Humans Liver cancer Liver Neoplasms - drug therapy Liver Neoplasms - genetics Liver Neoplasms - pathology Male Mesenchymal Stromal Cells - metabolism Mice, Inbred BALB C Mice, Nude MicroRNAs MicroRNAs - genetics Microscopy, Confocal Niacinamide - analogs & derivatives Niacinamide - pharmacology Oncology Phenylurea Compounds - pharmacology Proteins Reverse Transcriptase Polymerase Chain Reaction Xenograft Model Antitumor Assays
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