Physiological time structure of the tibialis anterior motor activity during sleep in mice, rats and humans
Summary The validation of rodent models for restless legs syndrome (Willis–Ekbom disease) and periodic limb movements during sleep requires knowledge of physiological limb motor activity during sleep in rodents. This study aimed to determine the physiological time structure of tibialis anterior acti...
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| Veröffentlicht in: | Journal of sleep research 2015-12, Vol.24 (6), p.695-701 |
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| creator | Silvani, Alessandro Martire, Viviana LO Salvadè, Agnese Bastianini, Stefano Ferri, Raffaele Berteotti, Chiara Baracchi, Francesca Pace, Marta Bassetti, Claudio L. Zoccoli, Giovanna Manconi, Mauro |
| description | Summary
The validation of rodent models for restless legs syndrome (Willis–Ekbom disease) and periodic limb movements during sleep requires knowledge of physiological limb motor activity during sleep in rodents. This study aimed to determine the physiological time structure of tibialis anterior activity during sleep in mice and rats, and compare it with that of healthy humans. Wild‐type mice (n = 9) and rats (n = 8) were instrumented with electrodes for recording the electroencephalogram and electromyogram of neck muscles and both tibialis anterior muscles. Healthy human subjects (31 ± 1 years, n = 21) underwent overnight polysomnography. An algorithm for automatic scoring of tibialis anterior electromyogram events of mice and rats during non‐rapid eye movement sleep was developed and validated. Visual scoring assisted by this algorithm had inter‐rater sensitivity of 92–95% and false‐positive rates of 13–19% in mice and rats. The distribution of the time intervals between consecutive tibialis anterior electromyogram events during non‐rapid eye movement sleep had a single peak extending up to 10 s in mice, rats and human subjects. The tibialis anterior electromyogram events separated by intervals |
| doi_str_mv | 10.1111/jsr.12319 |
| format | Article |
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The validation of rodent models for restless legs syndrome (Willis–Ekbom disease) and periodic limb movements during sleep requires knowledge of physiological limb motor activity during sleep in rodents. This study aimed to determine the physiological time structure of tibialis anterior activity during sleep in mice and rats, and compare it with that of healthy humans. Wild‐type mice (n = 9) and rats (n = 8) were instrumented with electrodes for recording the electroencephalogram and electromyogram of neck muscles and both tibialis anterior muscles. Healthy human subjects (31 ± 1 years, n = 21) underwent overnight polysomnography. An algorithm for automatic scoring of tibialis anterior electromyogram events of mice and rats during non‐rapid eye movement sleep was developed and validated. Visual scoring assisted by this algorithm had inter‐rater sensitivity of 92–95% and false‐positive rates of 13–19% in mice and rats. The distribution of the time intervals between consecutive tibialis anterior electromyogram events during non‐rapid eye movement sleep had a single peak extending up to 10 s in mice, rats and human subjects. The tibialis anterior electromyogram events separated by intervals <10 s mainly occurred in series of two‐three events, their occurrence rate in humans being lower than in mice and similar to that in rats. In conclusion, this study proposes reliable rules for scoring tibialis anterior electromyogram events during non‐rapid eye movement sleep in mice and rats, demonstrating that their physiological time structure is similar to that of healthy young human subjects. These results strengthen the basis for translational rodent models of periodic limb movements during sleep and restless legs syndrome/Willis–Ekbom disease.</description><identifier>ISSN: 0962-1105</identifier><identifier>EISSN: 1365-2869</identifier><identifier>DOI: 10.1111/jsr.12319</identifier><identifier>PMID: 26118726</identifier><language>eng</language><publisher>England</publisher><subject>Adult ; Algorithms ; animal ; Animals ; computer‐assisted detection ; Disease Models, Animal ; Electroencephalography ; Electromyography ; Female ; Healthy Volunteers ; Humans ; Leg - physiology ; Male ; Mice ; Mice, Inbred C57BL ; Movement - physiology ; Muscle, Skeletal - physiology ; nocturnal myoclonus ; normative data ; Polysomnography ; Rats ; Rats, Sprague-Dawley ; Restless Legs Syndrome - physiopathology ; Sleep - physiology ; sleep related movement disorders ; Time Factors</subject><ispartof>Journal of sleep research, 2015-12, Vol.24 (6), p.695-701</ispartof><rights>2015 European Sleep Research Society</rights><rights>2015 European Sleep Research Society.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4619-4c3db1da3bd7caac81567e91bb7b9a1dceb9bf747af3bfc8f8671e6b6a34b843</citedby><cites>FETCH-LOGICAL-c4619-4c3db1da3bd7caac81567e91bb7b9a1dceb9bf747af3bfc8f8671e6b6a34b843</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fjsr.12319$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fjsr.12319$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,1427,27901,27902,45550,45551,46384,46808</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26118726$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Silvani, Alessandro</creatorcontrib><creatorcontrib>Martire, Viviana LO</creatorcontrib><creatorcontrib>Salvadè, Agnese</creatorcontrib><creatorcontrib>Bastianini, Stefano</creatorcontrib><creatorcontrib>Ferri, Raffaele</creatorcontrib><creatorcontrib>Berteotti, Chiara</creatorcontrib><creatorcontrib>Baracchi, Francesca</creatorcontrib><creatorcontrib>Pace, Marta</creatorcontrib><creatorcontrib>Bassetti, Claudio L.</creatorcontrib><creatorcontrib>Zoccoli, Giovanna</creatorcontrib><creatorcontrib>Manconi, Mauro</creatorcontrib><title>Physiological time structure of the tibialis anterior motor activity during sleep in mice, rats and humans</title><title>Journal of sleep research</title><addtitle>J Sleep Res</addtitle><description>Summary
The validation of rodent models for restless legs syndrome (Willis–Ekbom disease) and periodic limb movements during sleep requires knowledge of physiological limb motor activity during sleep in rodents. This study aimed to determine the physiological time structure of tibialis anterior activity during sleep in mice and rats, and compare it with that of healthy humans. Wild‐type mice (n = 9) and rats (n = 8) were instrumented with electrodes for recording the electroencephalogram and electromyogram of neck muscles and both tibialis anterior muscles. Healthy human subjects (31 ± 1 years, n = 21) underwent overnight polysomnography. An algorithm for automatic scoring of tibialis anterior electromyogram events of mice and rats during non‐rapid eye movement sleep was developed and validated. Visual scoring assisted by this algorithm had inter‐rater sensitivity of 92–95% and false‐positive rates of 13–19% in mice and rats. The distribution of the time intervals between consecutive tibialis anterior electromyogram events during non‐rapid eye movement sleep had a single peak extending up to 10 s in mice, rats and human subjects. The tibialis anterior electromyogram events separated by intervals <10 s mainly occurred in series of two‐three events, their occurrence rate in humans being lower than in mice and similar to that in rats. In conclusion, this study proposes reliable rules for scoring tibialis anterior electromyogram events during non‐rapid eye movement sleep in mice and rats, demonstrating that their physiological time structure is similar to that of healthy young human subjects. These results strengthen the basis for translational rodent models of periodic limb movements during sleep and restless legs syndrome/Willis–Ekbom disease.</description><subject>Adult</subject><subject>Algorithms</subject><subject>animal</subject><subject>Animals</subject><subject>computer‐assisted detection</subject><subject>Disease Models, Animal</subject><subject>Electroencephalography</subject><subject>Electromyography</subject><subject>Female</subject><subject>Healthy Volunteers</subject><subject>Humans</subject><subject>Leg - physiology</subject><subject>Male</subject><subject>Mice</subject><subject>Mice, Inbred C57BL</subject><subject>Movement - physiology</subject><subject>Muscle, Skeletal - physiology</subject><subject>nocturnal myoclonus</subject><subject>normative data</subject><subject>Polysomnography</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><subject>Restless Legs Syndrome - physiopathology</subject><subject>Sleep - physiology</subject><subject>sleep related movement disorders</subject><subject>Time Factors</subject><issn>0962-1105</issn><issn>1365-2869</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kMtOwzAQAC0EoqVw4AeQjyARms3DTo6o4qlKIOg9sp1N68pJiu2A8vektHDDh7W0mp3DEHIO4Q0Mb7p29gaiGPIDMoaYpUGUsfyQjMOcRQFAmI7IiXPrMASexvkxGUUMIOMRG5P166p3ujXtUithqNc1Uudtp3xnkbYV9SsctlILox0VjUerW0vr1g9TKK8_te9p2VndLKkziBuqG1prhdfUCr89Kemqq0XjTslRJYzDs_0_IYv7u8XsMZi_PDzNbueBShjkQaLiUkIpYllyJYTKIGUcc5CSy1xAqVDmsuIJF1UsK5VVGeOATDIRJzJL4gm53Gk3tv3o0Pmi1k6hMaLBtnMF8KEOj8IsHdCrHaps65zFqthYXQvbFxAW27LFULb4KTuwF3ttJ2ss_8jflAMw3QFf2mD_v6l4fn_bKb8BOBaFiA</recordid><startdate>201512</startdate><enddate>201512</enddate><creator>Silvani, Alessandro</creator><creator>Martire, Viviana LO</creator><creator>Salvadè, Agnese</creator><creator>Bastianini, Stefano</creator><creator>Ferri, Raffaele</creator><creator>Berteotti, Chiara</creator><creator>Baracchi, Francesca</creator><creator>Pace, Marta</creator><creator>Bassetti, Claudio L.</creator><creator>Zoccoli, Giovanna</creator><creator>Manconi, Mauro</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>201512</creationdate><title>Physiological time structure of the tibialis anterior motor activity during sleep in mice, rats and humans</title><author>Silvani, Alessandro ; Martire, Viviana LO ; Salvadè, Agnese ; Bastianini, Stefano ; Ferri, Raffaele ; Berteotti, Chiara ; Baracchi, Francesca ; Pace, Marta ; Bassetti, Claudio L. ; Zoccoli, Giovanna ; Manconi, Mauro</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4619-4c3db1da3bd7caac81567e91bb7b9a1dceb9bf747af3bfc8f8671e6b6a34b843</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Adult</topic><topic>Algorithms</topic><topic>animal</topic><topic>Animals</topic><topic>computer‐assisted detection</topic><topic>Disease Models, Animal</topic><topic>Electroencephalography</topic><topic>Electromyography</topic><topic>Female</topic><topic>Healthy Volunteers</topic><topic>Humans</topic><topic>Leg - physiology</topic><topic>Male</topic><topic>Mice</topic><topic>Mice, Inbred C57BL</topic><topic>Movement - physiology</topic><topic>Muscle, Skeletal - physiology</topic><topic>nocturnal myoclonus</topic><topic>normative data</topic><topic>Polysomnography</topic><topic>Rats</topic><topic>Rats, Sprague-Dawley</topic><topic>Restless Legs Syndrome - physiopathology</topic><topic>Sleep - physiology</topic><topic>sleep related movement disorders</topic><topic>Time Factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Silvani, Alessandro</creatorcontrib><creatorcontrib>Martire, Viviana LO</creatorcontrib><creatorcontrib>Salvadè, Agnese</creatorcontrib><creatorcontrib>Bastianini, Stefano</creatorcontrib><creatorcontrib>Ferri, Raffaele</creatorcontrib><creatorcontrib>Berteotti, Chiara</creatorcontrib><creatorcontrib>Baracchi, Francesca</creatorcontrib><creatorcontrib>Pace, Marta</creatorcontrib><creatorcontrib>Bassetti, Claudio L.</creatorcontrib><creatorcontrib>Zoccoli, Giovanna</creatorcontrib><creatorcontrib>Manconi, Mauro</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of sleep research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Silvani, Alessandro</au><au>Martire, Viviana LO</au><au>Salvadè, Agnese</au><au>Bastianini, Stefano</au><au>Ferri, Raffaele</au><au>Berteotti, Chiara</au><au>Baracchi, Francesca</au><au>Pace, Marta</au><au>Bassetti, Claudio L.</au><au>Zoccoli, Giovanna</au><au>Manconi, Mauro</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Physiological time structure of the tibialis anterior motor activity during sleep in mice, rats and humans</atitle><jtitle>Journal of sleep research</jtitle><addtitle>J Sleep Res</addtitle><date>2015-12</date><risdate>2015</risdate><volume>24</volume><issue>6</issue><spage>695</spage><epage>701</epage><pages>695-701</pages><issn>0962-1105</issn><eissn>1365-2869</eissn><abstract>Summary
The validation of rodent models for restless legs syndrome (Willis–Ekbom disease) and periodic limb movements during sleep requires knowledge of physiological limb motor activity during sleep in rodents. This study aimed to determine the physiological time structure of tibialis anterior activity during sleep in mice and rats, and compare it with that of healthy humans. Wild‐type mice (n = 9) and rats (n = 8) were instrumented with electrodes for recording the electroencephalogram and electromyogram of neck muscles and both tibialis anterior muscles. Healthy human subjects (31 ± 1 years, n = 21) underwent overnight polysomnography. An algorithm for automatic scoring of tibialis anterior electromyogram events of mice and rats during non‐rapid eye movement sleep was developed and validated. Visual scoring assisted by this algorithm had inter‐rater sensitivity of 92–95% and false‐positive rates of 13–19% in mice and rats. The distribution of the time intervals between consecutive tibialis anterior electromyogram events during non‐rapid eye movement sleep had a single peak extending up to 10 s in mice, rats and human subjects. The tibialis anterior electromyogram events separated by intervals <10 s mainly occurred in series of two‐three events, their occurrence rate in humans being lower than in mice and similar to that in rats. In conclusion, this study proposes reliable rules for scoring tibialis anterior electromyogram events during non‐rapid eye movement sleep in mice and rats, demonstrating that their physiological time structure is similar to that of healthy young human subjects. These results strengthen the basis for translational rodent models of periodic limb movements during sleep and restless legs syndrome/Willis–Ekbom disease.</abstract><cop>England</cop><pmid>26118726</pmid><doi>10.1111/jsr.12319</doi><tpages>7</tpages></addata></record> |
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| subjects | Adult Algorithms animal Animals computer‐assisted detection Disease Models, Animal Electroencephalography Electromyography Female Healthy Volunteers Humans Leg - physiology Male Mice Mice, Inbred C57BL Movement - physiology Muscle, Skeletal - physiology nocturnal myoclonus normative data Polysomnography Rats Rats, Sprague-Dawley Restless Legs Syndrome - physiopathology Sleep - physiology sleep related movement disorders Time Factors |
| title | Physiological time structure of the tibialis anterior motor activity during sleep in mice, rats and humans |
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