Hydroxychloroquine reduces microglial activity and attenuates experimental autoimmune encephalomyelitis

Abstract Background Microglial activation is thought to be a key pathophysiological mechanism underlying disease activity in all forms of MS. Hydroxychloroquine (HCQ) is an antimalarial drug with immunomodulatory properties that is widely used in the treatment of rheumatological diseases. In this se...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Journal of the neurological sciences 2015-11, Vol.358 (1), p.131-137
Hauptverfasser:	Koch, Marcus W, Zabad, Rana, Giuliani, Fabrizio, Hader, Walter, Lewkonia, Ray, Metz, Luanne, Wee Yong, V
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cytokines - metabolism EAE Encephalomyelitis, Autoimmune, Experimental - drug therapy Encephalomyelitis, Autoimmune, Experimental - metabolism Encephalomyelitis, Autoimmune, Experimental - pathology Humans Hydroxychloroquine Hydroxychloroquine - pharmacology Hydroxychloroquine - therapeutic use Macrophage Macrophages - drug effects Macrophages - metabolism Mice Microglia Microglia - drug effects Microglia - metabolism Multiple sclerosis Neurology Spinal Cord - drug effects Spinal Cord - metabolism Spinal Cord - pathology Treatment Outcome
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!