Matrix Metalloproteinase-9 in the Culprit Coronary Artery and Myocardial No-Reflow
Background Matrix Metalloproteinases (MMPs) have been implicated in the pathogenesis of acute myocardial infarction (AMI). However, little is known about the association between MMP-9 and myocardial no-reflow. The aim of this study was to evaluate the role of MMP-9 in the culprit coronary artery as...
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| Veröffentlicht in: | The American journal of the medical sciences 2015-11, Vol.350 (5), p.352-356 |
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| creator | Dong, Mei, MD, PhD Ren, Faxin, MD, PhD Li, Fengli, MM Zhang, Chuanhuan, MM Yang, Jun, MD, PhD Mu, Nan, MD, PhD |
| description | Background Matrix Metalloproteinases (MMPs) have been implicated in the pathogenesis of acute myocardial infarction (AMI). However, little is known about the association between MMP-9 and myocardial no-reflow. The aim of this study was to evaluate the role of MMP-9 in the culprit coronary artery as a predictor of no-reflow in patients with ST-elevation AMI. Methods Ninety patients with ST-elevation AMI who underwent emergency percutaneous coronary intervention were consecutively recruited in this study. Blood samples were obtained from the extraction catheter placed distal to the culprit lesion at the beginning of percutaneous coronary intervention. No-reflow was defined as a coronary thrombolysis in myocardial infarction flow grade ≤2 after vessel reopening or thrombolysis in myocardial infarction flow 3 with a final myocardial blush grade ≤2. Results No-reflow was observed in 25 patients (27.8%). Using multiple logistic regression analysis, local MMP-9 levels (odds ratio [OR] = 3.356; confidence interval [CI]: 1.441–5.881; P = 0.007) were found to be a significant risk factor of no-reflow together with lesion length (OR = 6.985; CI: 2.574–11.533; P = 0.009) and time to balloon (OR = 2.143; CI: 1.216–5.901; P = 0.042). Conclusions Elevation of MMP-9 level in the culprit coronary artery may predict no-reflow in patients with ST-elevation AMI. |
| doi_str_mv | 10.1097/MAJ.0000000000000559 |
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However, little is known about the association between MMP-9 and myocardial no-reflow. The aim of this study was to evaluate the role of MMP-9 in the culprit coronary artery as a predictor of no-reflow in patients with ST-elevation AMI. Methods Ninety patients with ST-elevation AMI who underwent emergency percutaneous coronary intervention were consecutively recruited in this study. Blood samples were obtained from the extraction catheter placed distal to the culprit lesion at the beginning of percutaneous coronary intervention. No-reflow was defined as a coronary thrombolysis in myocardial infarction flow grade ≤2 after vessel reopening or thrombolysis in myocardial infarction flow 3 with a final myocardial blush grade ≤2. Results No-reflow was observed in 25 patients (27.8%). Using multiple logistic regression analysis, local MMP-9 levels (odds ratio [OR] = 3.356; confidence interval [CI]: 1.441–5.881; P = 0.007) were found to be a significant risk factor of no-reflow together with lesion length (OR = 6.985; CI: 2.574–11.533; P = 0.009) and time to balloon (OR = 2.143; CI: 1.216–5.901; P = 0.042). Conclusions Elevation of MMP-9 level in the culprit coronary artery may predict no-reflow in patients with ST-elevation AMI.</description><identifier>ISSN: 0002-9629</identifier><identifier>EISSN: 1538-2990</identifier><identifier>DOI: 10.1097/MAJ.0000000000000559</identifier><identifier>PMID: 26359995</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Acute myocardial infarction ; Aged ; Angioplasty, Balloon, Coronary - adverse effects ; Angioplasty, Balloon, Coronary - methods ; Coronary Angiography - methods ; Coronary Circulation ; Coronary Vessels - pathology ; Coronary Vessels - physiopathology ; Electrocardiography - methods ; Female ; Humans ; Inflammation ; Internal Medicine ; Male ; Matrix Metalloproteinase 9 - blood ; Middle Aged ; MMP-9 ; Myocardial Infarction - diagnosis ; Myocardial Infarction - physiopathology ; Myocardial Infarction - therapy ; No-reflow ; No-Reflow Phenomenon - blood ; No-Reflow Phenomenon - diagnosis ; No-Reflow Phenomenon - etiology ; No-Reflow Phenomenon - physiopathology ; Predictive Value of Tests ; Prognosis</subject><ispartof>The American journal of the medical sciences, 2015-11, Vol.350 (5), p.352-356</ispartof><rights>Southern Society for Clinical Investigation</rights><rights>2015 Southern Society for Clinical Investigation</rights><rights>Copyright © 2015 by the Southern Society for Clinical Investigation. Unauthorized reproduction of this article is prohibited.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4669-d0d59befaa708a72fa870f42214155df0edb8d98e5887b501d61cc09905231e53</citedby><cites>FETCH-LOGICAL-c4669-d0d59befaa708a72fa870f42214155df0edb8d98e5887b501d61cc09905231e53</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,777,781,27905,27906</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26359995$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Dong, Mei, MD, PhD</creatorcontrib><creatorcontrib>Ren, Faxin, MD, PhD</creatorcontrib><creatorcontrib>Li, Fengli, MM</creatorcontrib><creatorcontrib>Zhang, Chuanhuan, MM</creatorcontrib><creatorcontrib>Yang, Jun, MD, PhD</creatorcontrib><creatorcontrib>Mu, Nan, MD, PhD</creatorcontrib><title>Matrix Metalloproteinase-9 in the Culprit Coronary Artery and Myocardial No-Reflow</title><title>The American journal of the medical sciences</title><addtitle>Am J Med Sci</addtitle><description>Background Matrix Metalloproteinases (MMPs) have been implicated in the pathogenesis of acute myocardial infarction (AMI). However, little is known about the association between MMP-9 and myocardial no-reflow. The aim of this study was to evaluate the role of MMP-9 in the culprit coronary artery as a predictor of no-reflow in patients with ST-elevation AMI. Methods Ninety patients with ST-elevation AMI who underwent emergency percutaneous coronary intervention were consecutively recruited in this study. Blood samples were obtained from the extraction catheter placed distal to the culprit lesion at the beginning of percutaneous coronary intervention. No-reflow was defined as a coronary thrombolysis in myocardial infarction flow grade ≤2 after vessel reopening or thrombolysis in myocardial infarction flow 3 with a final myocardial blush grade ≤2. Results No-reflow was observed in 25 patients (27.8%). Using multiple logistic regression analysis, local MMP-9 levels (odds ratio [OR] = 3.356; confidence interval [CI]: 1.441–5.881; P = 0.007) were found to be a significant risk factor of no-reflow together with lesion length (OR = 6.985; CI: 2.574–11.533; P = 0.009) and time to balloon (OR = 2.143; CI: 1.216–5.901; P = 0.042). Conclusions Elevation of MMP-9 level in the culprit coronary artery may predict no-reflow in patients with ST-elevation AMI.</description><subject>Acute myocardial infarction</subject><subject>Aged</subject><subject>Angioplasty, Balloon, Coronary - adverse effects</subject><subject>Angioplasty, Balloon, Coronary - methods</subject><subject>Coronary Angiography - methods</subject><subject>Coronary Circulation</subject><subject>Coronary Vessels - pathology</subject><subject>Coronary Vessels - physiopathology</subject><subject>Electrocardiography - methods</subject><subject>Female</subject><subject>Humans</subject><subject>Inflammation</subject><subject>Internal Medicine</subject><subject>Male</subject><subject>Matrix Metalloproteinase 9 - blood</subject><subject>Middle Aged</subject><subject>MMP-9</subject><subject>Myocardial Infarction - diagnosis</subject><subject>Myocardial Infarction - physiopathology</subject><subject>Myocardial Infarction - therapy</subject><subject>No-reflow</subject><subject>No-Reflow Phenomenon - blood</subject><subject>No-Reflow Phenomenon - diagnosis</subject><subject>No-Reflow Phenomenon - etiology</subject><subject>No-Reflow Phenomenon - physiopathology</subject><subject>Predictive Value of Tests</subject><subject>Prognosis</subject><issn>0002-9629</issn><issn>1538-2990</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqVkk9rGzEQxUVoSdyk3yCEPfayqUa72pUuAWPSf8QtJO1ZyNIsViKvEklb19--Mk5L6aVUlwHx3sy8H0PIOdBLoLJ_u5x_uqR_Ps7lEZkBb0TNpKQvyKx8slp2TJ6QVyndUwpMQHNMTljXcCkln5Hbpc7R_aiWmLX34TGGjG7UCWtZubHKa6wWk3-MLleLEMOo466ax4yl6NFWy10wOlqnffU51Lc4-LA9Iy8H7RO-fq6n5Nu766-LD_XNl_cfF_Ob2rRdJ2tLLZcrHLTuqdA9G7To6dAyBi1wbgeKdiWsFMiF6Fecgu3AGFqScdYA8uaUvDn0LUs_TZiy2rhk0Hs9YpiSgp6JMqgDKNL2IDUxpBRxUCXRpmRRQNWepio01d80i-3iecK02qD9bfqFrwjEQbANvjBJD37aYlRr1D6v_9X76mDFgui7K65kHI4GrYtosrLB_W8D493ojPYPuMN0H6Y4FvwKVGKKqrv9MexvAXgLDWto8xMSLKgg</recordid><startdate>201511</startdate><enddate>201511</enddate><creator>Dong, Mei, MD, PhD</creator><creator>Ren, Faxin, MD, PhD</creator><creator>Li, Fengli, MM</creator><creator>Zhang, Chuanhuan, MM</creator><creator>Yang, Jun, MD, PhD</creator><creator>Mu, Nan, MD, PhD</creator><general>Elsevier Inc</general><general>Copyright by the Southern Society for Clinical Investigation. Unauthorized reproduction of this article is prohibited</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>201511</creationdate><title>Matrix Metalloproteinase-9 in the Culprit Coronary Artery and Myocardial No-Reflow</title><author>Dong, Mei, MD, PhD ; Ren, Faxin, MD, PhD ; Li, Fengli, MM ; Zhang, Chuanhuan, MM ; Yang, Jun, MD, PhD ; Mu, Nan, MD, PhD</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4669-d0d59befaa708a72fa870f42214155df0edb8d98e5887b501d61cc09905231e53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Acute myocardial infarction</topic><topic>Aged</topic><topic>Angioplasty, Balloon, Coronary - adverse effects</topic><topic>Angioplasty, Balloon, Coronary - methods</topic><topic>Coronary Angiography - methods</topic><topic>Coronary Circulation</topic><topic>Coronary Vessels - pathology</topic><topic>Coronary Vessels - physiopathology</topic><topic>Electrocardiography - methods</topic><topic>Female</topic><topic>Humans</topic><topic>Inflammation</topic><topic>Internal Medicine</topic><topic>Male</topic><topic>Matrix Metalloproteinase 9 - blood</topic><topic>Middle Aged</topic><topic>MMP-9</topic><topic>Myocardial Infarction - diagnosis</topic><topic>Myocardial Infarction - physiopathology</topic><topic>Myocardial Infarction - therapy</topic><topic>No-reflow</topic><topic>No-Reflow Phenomenon - blood</topic><topic>No-Reflow Phenomenon - diagnosis</topic><topic>No-Reflow Phenomenon - etiology</topic><topic>No-Reflow Phenomenon - physiopathology</topic><topic>Predictive Value of Tests</topic><topic>Prognosis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Dong, Mei, MD, PhD</creatorcontrib><creatorcontrib>Ren, Faxin, MD, PhD</creatorcontrib><creatorcontrib>Li, Fengli, MM</creatorcontrib><creatorcontrib>Zhang, Chuanhuan, MM</creatorcontrib><creatorcontrib>Yang, Jun, MD, PhD</creatorcontrib><creatorcontrib>Mu, Nan, MD, PhD</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>The American journal of the medical sciences</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Dong, Mei, MD, PhD</au><au>Ren, Faxin, MD, PhD</au><au>Li, Fengli, MM</au><au>Zhang, Chuanhuan, MM</au><au>Yang, Jun, MD, PhD</au><au>Mu, Nan, MD, PhD</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Matrix Metalloproteinase-9 in the Culprit Coronary Artery and Myocardial No-Reflow</atitle><jtitle>The American journal of the medical sciences</jtitle><addtitle>Am J Med Sci</addtitle><date>2015-11</date><risdate>2015</risdate><volume>350</volume><issue>5</issue><spage>352</spage><epage>356</epage><pages>352-356</pages><issn>0002-9629</issn><eissn>1538-2990</eissn><abstract>Background Matrix Metalloproteinases (MMPs) have been implicated in the pathogenesis of acute myocardial infarction (AMI). However, little is known about the association between MMP-9 and myocardial no-reflow. The aim of this study was to evaluate the role of MMP-9 in the culprit coronary artery as a predictor of no-reflow in patients with ST-elevation AMI. Methods Ninety patients with ST-elevation AMI who underwent emergency percutaneous coronary intervention were consecutively recruited in this study. Blood samples were obtained from the extraction catheter placed distal to the culprit lesion at the beginning of percutaneous coronary intervention. No-reflow was defined as a coronary thrombolysis in myocardial infarction flow grade ≤2 after vessel reopening or thrombolysis in myocardial infarction flow 3 with a final myocardial blush grade ≤2. Results No-reflow was observed in 25 patients (27.8%). Using multiple logistic regression analysis, local MMP-9 levels (odds ratio [OR] = 3.356; confidence interval [CI]: 1.441–5.881; P = 0.007) were found to be a significant risk factor of no-reflow together with lesion length (OR = 6.985; CI: 2.574–11.533; P = 0.009) and time to balloon (OR = 2.143; CI: 1.216–5.901; P = 0.042). Conclusions Elevation of MMP-9 level in the culprit coronary artery may predict no-reflow in patients with ST-elevation AMI.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>26359995</pmid><doi>10.1097/MAJ.0000000000000559</doi><tpages>5</tpages></addata></record> |
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| subjects | Acute myocardial infarction Aged Angioplasty, Balloon, Coronary - adverse effects Angioplasty, Balloon, Coronary - methods Coronary Angiography - methods Coronary Circulation Coronary Vessels - pathology Coronary Vessels - physiopathology Electrocardiography - methods Female Humans Inflammation Internal Medicine Male Matrix Metalloproteinase 9 - blood Middle Aged MMP-9 Myocardial Infarction - diagnosis Myocardial Infarction - physiopathology Myocardial Infarction - therapy No-reflow No-Reflow Phenomenon - blood No-Reflow Phenomenon - diagnosis No-Reflow Phenomenon - etiology No-Reflow Phenomenon - physiopathology Predictive Value of Tests Prognosis |
| title | Matrix Metalloproteinase-9 in the Culprit Coronary Artery and Myocardial No-Reflow |
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