Rat Kidney Pathology Induced by Chronic Exposure to Fumonisin B1 Includes Rare Variants of Renal Tubule Tumor

The carcinogenicity of fumonisin B1 (FB1), a worldwide contaminant of corn produced by Fusaria species of fungi, has been tested recently in 2-year feeding studies in Fischer F344 rats and B6C3F1 mice. Inclusion of FB1 at 50 and 80 ppm in the diet induced liver tumors in female mice, and at 50 and 1...

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Veröffentlicht in:	Toxicologic pathology 2001-05, Vol.29 (3), p.379-386
Hauptverfasser:	Hard, Gordon C., Howard, Paul C., Kovatch, Robert M., Bucci, Thomas J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenoma - chemically induced Adenoma - pathology Animals Carboxylic Acids - administration & dosage Carboxylic Acids - toxicity Carcinogenicity Tests Carcinogens, Environmental - administration & dosage Carcinogens, Environmental - toxicity Carcinoma - chemically induced Carcinoma - secondary Diet Dose-Response Relationship, Drug Female Fumonisins Hyperplasia - chemically induced Hyperplasia - pathology Kidney Neoplasms - chemically induced Kidney Neoplasms - pathology Kidney Tubules, Proximal - pathology Male Mycotoxins - administration & dosage Mycotoxins - toxicity Precancerous Conditions - chemically induced Precancerous Conditions - pathology Rats Rats, Inbred F344
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