Gut-expressed gustducin and taste receptors regulate secretion of glucagon-like peptide-1

Glucagon-like peptide-1 (GLP-1), released from gut endocrine L cells in response to glucose, regulates appetite, insulin secretion, and gut motility. How glucose given orally, but not systemically, induces GLP-1 secretion is unknown. We show that human duodenal L cells express sweet taste receptors,...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2007-09, Vol.104 (38), p.15069-15074
Hauptverfasser:	Jang, Hyeung-Jin, Kokrashvili, Zaza, Theodorakis, Michael J, Carlson, Olga D, Kim, Byung-Joon, Zhou, Jie, Kim, Hyeon Ho, Xu, Xiangru, Chan, Sic L, Juhaszova, Magdalena, Bernier, Michel, Mosinger, Bedrich, Margolskee, Robert F, Egan, Josephine M
Format:	Artikel
Sprache:	eng
Schlagworte:	alpha-gustducin Animals Biological Sciences Cell lines Cells, Cultured chemoreceptors digestive physiology Digestive system Duodenum Duodenum - metabolism Endocrine system enterocytes Enteroendocrine cells Enteroendocrine Cells - metabolism Epithelial cells Fluorescent Antibody Technique food intake Glucagon-Like Peptide 1 - metabolism glucagon-like peptides Glucose Glucose - metabolism gustducin Heterotrimeric GTP-Binding Proteins - metabolism hormone secretion Hormones human cell lines Humans L cells Mice Mice, Inbred C57BL Mice, Transgenic nutrient availability Peptides Receptors Receptors, G-Protein-Coupled - metabolism Secretion signal transduction Small interfering RNA small intestine Taste cells villi
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!