Dopamine and glutamate neurotoxicity in cultured chick telencephali cells: effects of nmda antagonists, antioxidants and mao inhibitors

In a recent study, it was found that the intrastriatal administration to rats of the organophosphorous compound soman and kainic acid produced a rapid release not only of glutamate but also of dopamine in this brain region. Dopamine is a potent source of free radicals and is known to produce cytotox...

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Veröffentlicht in:	Neurochemistry international 1999, Vol.34 (1), p.49-62
Hauptverfasser:	Jacobsson, S.o.p, Fowler, C.J
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antioxidants - pharmacology Biological and medical sciences Cell Death Cells, Cultured Central nervous system Central neurotransmission. Neuromudulation. Pathways and receptors Chick Embryo Chick neurons Dopamine Dopamine - administration & dosage Dopamine - toxicity Drug Interactions Fundamental and applied biological sciences. Psychology Glutamate Glutamic Acid - administration & dosage Glutamic Acid - toxicity Lipid Peroxidation - drug effects Melanins - metabolism Monoamine oxidase Monoamine Oxidase - metabolism Monoamine Oxidase Inhibitors - pharmacology N-Methylaspartate - antagonists & inhibitors Neurons - drug effects Neurotoxicity Oxidative stress Soman Telencephalon - drug effects Telencephalon - embryology Telencephalon - enzymology Vertebrates: nervous system and sense organs
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