Changes in the extracellular profiles of neuroactive amino acids in the rat striatum at the asymptomatic stage of hepatic failure

Rats were treated with a hepatotoxin thioacetamide (TAA) and examined 21 days later, when they showed moderate fatty metamorphosis of the liver and morphological changes in brain indicative of excitotoxic neuronal damage, but no evident biochemical or neurophysiological symptoms of hepatic encephalo...

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Veröffentlicht in:	Journal of neuroscience research 1999-04, Vol.56 (1), p.76-84
Hauptverfasser:	Hilgier, W., Zielińska, M., Borkowska, H.D., Gadamski, R., Walski, M., Oja, S.S., Saransaari, P., Albrecht, J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Alanine - metabolism Amino Acids - blood Animals aspartate Aspartic Acid - metabolism Biological Transport Corpus Striatum - drug effects Corpus Striatum - metabolism Corpus Striatum - pathology Excitatory Amino Acids - metabolism Fatty Liver - chemically induced Fatty Liver - metabolism Fatty Liver - pathology Gliosis glutamate Glutamic Acid - metabolism Glutamine - metabolism Hepatic Encephalopathy - chemically induced Hepatic Encephalopathy - metabolism Hepatic Encephalopathy - pathology hepatic failure Liver - drug effects Liver - metabolism Liver - pathology Male Microdialysis Potassium - pharmacology rat Rats Rats, Wistar striatum subclinical hepatic encephalopathy taurine Taurine - metabolism Thioacetamide - toxicity
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