Orthogonal bioorthogonal chemistries
•Mutually orthogonal bioorthogonal reactions are described.•Current challenges in compatible reaction development are outlined.•Strategies to identify and generate orthogonal reactions are presented.•Recent applications of orthogonal bioorthogonal reactions in cellular imaging and macromolecular ass...
Gespeichert in:
| Veröffentlicht in: | Current opinion in chemical biology 2015-10, Vol.28, p.141-149 |
|---|---|
| Hauptverfasser: | , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 149 |
|---|---|
| container_issue | |
| container_start_page | 141 |
| container_title | Current opinion in chemical biology |
| container_volume | 28 |
| creator | Patterson, David M Prescher, Jennifer A |
| description | •Mutually orthogonal bioorthogonal reactions are described.•Current challenges in compatible reaction development are outlined.•Strategies to identify and generate orthogonal reactions are presented.•Recent applications of orthogonal bioorthogonal reactions in cellular imaging and macromolecular assembly are highlighted.
Bioorthogonal reactions have long been used to examine individual biomolecules in living systems. Studies of multi-component networks demand not only reliable bioorthogonal chemistries, but also combinations of reactions that can be used in tandem. Such ‘orthogonal bioorthogonal’ transformations have been reported in recent years, and these chemistries are enabling new explorations into biology. This article highlights the development of orthogonal bioorthogonal reactions and their application in multi-target imaging and macromolecule assembly. Methods to tune and control orthogonal reactivity are also discussed, along with prospects for identifying new classes of compatible reactions. |
| doi_str_mv | 10.1016/j.cbpa.2015.07.006 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1728262861</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S1367593115000824</els_id><sourcerecordid>1728262861</sourcerecordid><originalsourceid>FETCH-LOGICAL-c356t-52042d80dbfa5217d13c925a07f8f33e1af162da3a4d6a62740ae0a95320afb73</originalsourceid><addsrcrecordid>eNp9kE9LAzEQxYMoVqtfwIN48OBl10mySXbBixT_QaEXPYdsMmtTtk1NtoLf3pRWvXmaGfjN471HyAWFkgKVt4vStmtTMqCiBFUCyANyQmvVFFABO8w7l6oQDacjcprSAjLBanFMRkwyJfNxQq5ncZiH97Ay_VXrQ_i77ByXPg3RYzojR53pE57v55i8PT68Tp6L6ezpZXI_LSwXcigEg4q5GlzbGcGocpTbhgkDqqs7zpGajkrmDDeVkyZbqMAgmEZwBqZrFR-Tm53uOoaPDaZBZwcW-96sMGySporV2XotaUbZDrUxpBSx0-volyZ-aQp6245e6G07etuOBqVz9vx0udfftEt0vy8_dWTgbgdgTvnpMepkPa4sOh_RDtoF_5_-N9NsdJ4</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1728262861</pqid></control><display><type>article</type><title>Orthogonal bioorthogonal chemistries</title><source>MEDLINE</source><source>ScienceDirect Journals (5 years ago - present)</source><creator>Patterson, David M ; Prescher, Jennifer A</creator><creatorcontrib>Patterson, David M ; Prescher, Jennifer A</creatorcontrib><description>•Mutually orthogonal bioorthogonal reactions are described.•Current challenges in compatible reaction development are outlined.•Strategies to identify and generate orthogonal reactions are presented.•Recent applications of orthogonal bioorthogonal reactions in cellular imaging and macromolecular assembly are highlighted.
Bioorthogonal reactions have long been used to examine individual biomolecules in living systems. Studies of multi-component networks demand not only reliable bioorthogonal chemistries, but also combinations of reactions that can be used in tandem. Such ‘orthogonal bioorthogonal’ transformations have been reported in recent years, and these chemistries are enabling new explorations into biology. This article highlights the development of orthogonal bioorthogonal reactions and their application in multi-target imaging and macromolecule assembly. Methods to tune and control orthogonal reactivity are also discussed, along with prospects for identifying new classes of compatible reactions.</description><identifier>ISSN: 1367-5931</identifier><identifier>EISSN: 1879-0402</identifier><identifier>DOI: 10.1016/j.cbpa.2015.07.006</identifier><identifier>PMID: 26276062</identifier><language>eng</language><publisher>England: Elsevier Ltd</publisher><subject>Alkynes - chemistry ; Animals ; Azides - chemistry ; Biochemistry - methods ; Humans ; Models, Molecular ; Molecular Imaging - methods ; Proteins - analysis ; Proteins - metabolism</subject><ispartof>Current opinion in chemical biology, 2015-10, Vol.28, p.141-149</ispartof><rights>2015 Elsevier Ltd</rights><rights>Copyright © 2015 Elsevier Ltd. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c356t-52042d80dbfa5217d13c925a07f8f33e1af162da3a4d6a62740ae0a95320afb73</citedby><cites>FETCH-LOGICAL-c356t-52042d80dbfa5217d13c925a07f8f33e1af162da3a4d6a62740ae0a95320afb73</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.cbpa.2015.07.006$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26276062$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Patterson, David M</creatorcontrib><creatorcontrib>Prescher, Jennifer A</creatorcontrib><title>Orthogonal bioorthogonal chemistries</title><title>Current opinion in chemical biology</title><addtitle>Curr Opin Chem Biol</addtitle><description>•Mutually orthogonal bioorthogonal reactions are described.•Current challenges in compatible reaction development are outlined.•Strategies to identify and generate orthogonal reactions are presented.•Recent applications of orthogonal bioorthogonal reactions in cellular imaging and macromolecular assembly are highlighted.
Bioorthogonal reactions have long been used to examine individual biomolecules in living systems. Studies of multi-component networks demand not only reliable bioorthogonal chemistries, but also combinations of reactions that can be used in tandem. Such ‘orthogonal bioorthogonal’ transformations have been reported in recent years, and these chemistries are enabling new explorations into biology. This article highlights the development of orthogonal bioorthogonal reactions and their application in multi-target imaging and macromolecule assembly. Methods to tune and control orthogonal reactivity are also discussed, along with prospects for identifying new classes of compatible reactions.</description><subject>Alkynes - chemistry</subject><subject>Animals</subject><subject>Azides - chemistry</subject><subject>Biochemistry - methods</subject><subject>Humans</subject><subject>Models, Molecular</subject><subject>Molecular Imaging - methods</subject><subject>Proteins - analysis</subject><subject>Proteins - metabolism</subject><issn>1367-5931</issn><issn>1879-0402</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE9LAzEQxYMoVqtfwIN48OBl10mySXbBixT_QaEXPYdsMmtTtk1NtoLf3pRWvXmaGfjN471HyAWFkgKVt4vStmtTMqCiBFUCyANyQmvVFFABO8w7l6oQDacjcprSAjLBanFMRkwyJfNxQq5ncZiH97Ay_VXrQ_i77ByXPg3RYzojR53pE57v55i8PT68Tp6L6ezpZXI_LSwXcigEg4q5GlzbGcGocpTbhgkDqqs7zpGajkrmDDeVkyZbqMAgmEZwBqZrFR-Tm53uOoaPDaZBZwcW-96sMGySporV2XotaUbZDrUxpBSx0-volyZ-aQp6245e6G07etuOBqVz9vx0udfftEt0vy8_dWTgbgdgTvnpMepkPa4sOh_RDtoF_5_-N9NsdJ4</recordid><startdate>201510</startdate><enddate>201510</enddate><creator>Patterson, David M</creator><creator>Prescher, Jennifer A</creator><general>Elsevier Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>201510</creationdate><title>Orthogonal bioorthogonal chemistries</title><author>Patterson, David M ; Prescher, Jennifer A</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c356t-52042d80dbfa5217d13c925a07f8f33e1af162da3a4d6a62740ae0a95320afb73</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Alkynes - chemistry</topic><topic>Animals</topic><topic>Azides - chemistry</topic><topic>Biochemistry - methods</topic><topic>Humans</topic><topic>Models, Molecular</topic><topic>Molecular Imaging - methods</topic><topic>Proteins - analysis</topic><topic>Proteins - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Patterson, David M</creatorcontrib><creatorcontrib>Prescher, Jennifer A</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Current opinion in chemical biology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Patterson, David M</au><au>Prescher, Jennifer A</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Orthogonal bioorthogonal chemistries</atitle><jtitle>Current opinion in chemical biology</jtitle><addtitle>Curr Opin Chem Biol</addtitle><date>2015-10</date><risdate>2015</risdate><volume>28</volume><spage>141</spage><epage>149</epage><pages>141-149</pages><issn>1367-5931</issn><eissn>1879-0402</eissn><abstract>•Mutually orthogonal bioorthogonal reactions are described.•Current challenges in compatible reaction development are outlined.•Strategies to identify and generate orthogonal reactions are presented.•Recent applications of orthogonal bioorthogonal reactions in cellular imaging and macromolecular assembly are highlighted.
Bioorthogonal reactions have long been used to examine individual biomolecules in living systems. Studies of multi-component networks demand not only reliable bioorthogonal chemistries, but also combinations of reactions that can be used in tandem. Such ‘orthogonal bioorthogonal’ transformations have been reported in recent years, and these chemistries are enabling new explorations into biology. This article highlights the development of orthogonal bioorthogonal reactions and their application in multi-target imaging and macromolecule assembly. Methods to tune and control orthogonal reactivity are also discussed, along with prospects for identifying new classes of compatible reactions.</abstract><cop>England</cop><pub>Elsevier Ltd</pub><pmid>26276062</pmid><doi>10.1016/j.cbpa.2015.07.006</doi><tpages>9</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1367-5931 |
| ispartof | Current opinion in chemical biology, 2015-10, Vol.28, p.141-149 |
| issn | 1367-5931 1879-0402 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1728262861 |
| source | MEDLINE; ScienceDirect Journals (5 years ago - present) |
| subjects | Alkynes - chemistry Animals Azides - chemistry Biochemistry - methods Humans Models, Molecular Molecular Imaging - methods Proteins - analysis Proteins - metabolism |
| title | Orthogonal bioorthogonal chemistries |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-22T19%3A11%3A18IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Orthogonal%20bioorthogonal%20chemistries&rft.jtitle=Current%20opinion%20in%20chemical%20biology&rft.au=Patterson,%20David%20M&rft.date=2015-10&rft.volume=28&rft.spage=141&rft.epage=149&rft.pages=141-149&rft.issn=1367-5931&rft.eissn=1879-0402&rft_id=info:doi/10.1016/j.cbpa.2015.07.006&rft_dat=%3Cproquest_cross%3E1728262861%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1728262861&rft_id=info:pmid/26276062&rft_els_id=S1367593115000824&rfr_iscdi=true |