TIMP-1 affects the spatial distribution of dendritic processes of second-order neurons in a rat model of Retinitis Pigmentosa

Retinitis Pigmentosa (RP) is an inherited disorder that may lead to blindness. In the rhodopsin S334ter-line-3 rat model of RP, the death of rods induces spatial rearrangement of cones into regular ring mosaics. Using this model, we discovered that the ring mosaics are restored to a homogeneous dist...

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Veröffentlicht in:	Experimental eye research 2015-11, Vol.140, p.41-52
Hauptverfasser:	Shin, Jung-A., Eom, Yun Sung, Yu, Wan-Qing, Grzywacz, Norberto M., Craft, Cheryl Mae, Lee, Eun-Jin
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biomarkers - metabolism Bipolar cell Cell Count Cell Movement Cone mosaic Cone outer segment Dendrites - metabolism Disease Models, Animal Eye Proteins - metabolism Female Fluorescent Antibody Technique, Indirect Horizontal cell Intravitreal Injections Male Microscopy, Confocal Neuronal Plasticity - physiology Rats Rats, Sprague-Dawley Retinal Bipolar Cells - metabolism Retinal Cone Photoreceptor Cells - metabolism Retinal Cone Photoreceptor Cells - pathology Retinitis pigmentosa Retinitis Pigmentosa - drug therapy Retinitis Pigmentosa - metabolism Synaptic protein Tissue Inhibitor of Metalloproteinase-1 - administration & dosage Tissue Inhibitor of Metalloproteinase-1 - pharmacology Tissue inhibitor of metalloproteinase-1(TIMP-1)
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