Intratracheal Cell Transfer Demonstrates the Profibrotic Potential of Resident Fibroblasts in Pulmonary Fibrosis

Pulmonary fibrosis is a devastating disease for which there are few effective therapies. Activated fibroblasts form subepithelial clusters known as fibroblastic foci, which are characterized by excessive collagen deposition. The origin of activated fibroblasts is controversial and needs to be clarif...

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Veröffentlicht in:	The American journal of pathology 2015-11, Vol.185 (11), p.2939-2948
Hauptverfasser:	Tsukui, Tatsuya, Ueha, Satoshi, Shichino, Shigeyuki, Inagaki, Yutaka, Matsushima, Kouji
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Bleomycin - adverse effects Collagen - metabolism Disease Models, Animal Epithelial Cells - metabolism Epithelial Cells - pathology Epithelium - metabolism Epithelium - pathology Female Fibroblasts - metabolism Fibroblasts - pathology Gene Expression Regulation Genes, Reporter Male Mice Mice, Inbred C57BL Mice, Transgenic Pathology Pulmonary Alveoli - metabolism Pulmonary Alveoli - pathology Pulmonary Fibrosis - metabolism Pulmonary Fibrosis - pathology Up-Regulation
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