Th17 Cytokines Regulate Osteoclastogenesis in Rheumatoid Arthritis

This study determined the effect of type 17 helper T-cell (Th17) cytokines on osteoclastogenesis in rheumatoid arthritis (RA). The expression of IL-17 and receptor activator of NF-κB ligand (RANKL) was determined in synovial tissue, fibroblast-like synoviocytes (FLSs), and synovial fluids of RA pati...

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Veröffentlicht in:	The American journal of pathology 2015-11, Vol.185 (11), p.3011-3024
Hauptverfasser:	Kim, Kyoung-Woon, Kim, Hae-Rim, Kim, Bo-Mi, Cho, Mi-La, Lee, Sang-Heon
Format:	Artikel
Sprache:	eng
Schlagworte:	Acid Phosphatase Arthritis, Rheumatoid - immunology Arthritis, Rheumatoid - pathology Cell Differentiation Cytokines - genetics Cytokines - metabolism Fibroblasts - immunology Fibroblasts - metabolism Humans Isoenzymes Macrophage Colony-Stimulating Factor - genetics Macrophage Colony-Stimulating Factor - metabolism Monocytes - immunology Monocytes - metabolism Osteoclasts - immunology Osteoclasts - metabolism Osteogenesis - immunology Pathology RANK Ligand - genetics RANK Ligand - metabolism Signal Transduction Synovial Fluid - metabolism Tartrate-Resistant Acid Phosphatase Th17 Cells - immunology Th17 Cells - metabolism TNF Receptor-Associated Factor 6 - genetics TNF Receptor-Associated Factor 6 - metabolism Transcription Factor AP-1 - genetics Transcription Factor AP-1 - metabolism Tumor Necrosis Factor-alpha - genetics Tumor Necrosis Factor-alpha - metabolism Up-Regulation
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