Elevation of cardiovascular risk by non-steroidal anti-inflammatory drugs

Abstract Non-steroidal anti-inflammatory drugs (NSAIDs) are one of the most frequently used medications. NSAIDs profoundly modify prostaglandin homeostasis through inhibition of the enzyme, cyclooxygenase (COX), especially COX-2. COX-2 inhibition is associated with adverse cardiovascular outcomes as...

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Veröffentlicht in:	Trends in cardiovascular medicine 2015-11, Vol.25 (8), p.726-735
Hauptverfasser:	Anwar, Asif, MD, John Anwar, Imran, MS, Delafontaine, Patrice, MD
Format:	Artikel
Sprache:	eng
Schlagworte:	Acute coronary syndromes Adult Aged Anti-Inflammatory Agents, Non-Steroidal - adverse effects Anti-Inflammatory Agents, Non-Steroidal - therapeutic use Arthritis Aspirin Cardiovascular Cardiovascular disease Cardiovascular Diseases - enzymology Cardiovascular Diseases - etiology Cardiovascular Diseases - physiopathology Case-Control Studies Cell growth Cyclooxygenase 1 - drug effects Cyclooxygenase 1 - metabolism Cyclooxygenase 2 - drug effects Cyclooxygenase 2 - metabolism Cytokines Drug dosages Enzymes Female Follow-Up Studies Gene expression Growth factors Heart attacks Homeostasis Homeostasis - drug effects Humans Inflammation Lactones - adverse effects Lactones - therapeutic use Male Middle Aged Naproxen - adverse effects Naproxen - therapeutic use Patients Prevalence Randomized Controlled Trials as Topic Risk Assessment Rodents Smooth muscle Studies Sulfones - adverse effects Sulfones - therapeutic use Thrombosis
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