Elevation of cardiovascular risk by non-steroidal anti-inflammatory drugs
Abstract Non-steroidal anti-inflammatory drugs (NSAIDs) are one of the most frequently used medications. NSAIDs profoundly modify prostaglandin homeostasis through inhibition of the enzyme, cyclooxygenase (COX), especially COX-2. COX-2 inhibition is associated with adverse cardiovascular outcomes as...
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| Veröffentlicht in: | Trends in cardiovascular medicine 2015-11, Vol.25 (8), p.726-735 |
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| creator | Anwar, Asif, MD John Anwar, Imran, MS Delafontaine, Patrice, MD |
| description | Abstract Non-steroidal anti-inflammatory drugs (NSAIDs) are one of the most frequently used medications. NSAIDs profoundly modify prostaglandin homeostasis through inhibition of the enzyme, cyclooxygenase (COX), especially COX-2. COX-2 inhibition is associated with adverse cardiovascular outcomes as demonstrated by recent trials using this type of drug. This review explores the latest available data, including recent, randomized, clinical trials, controversies, and pathophysiology of the adverse effects of COX-inhibition. |
| doi_str_mv | 10.1016/j.tcm.2015.03.006 |
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NSAIDs profoundly modify prostaglandin homeostasis through inhibition of the enzyme, cyclooxygenase (COX), especially COX-2. COX-2 inhibition is associated with adverse cardiovascular outcomes as demonstrated by recent trials using this type of drug. This review explores the latest available data, including recent, randomized, clinical trials, controversies, and pathophysiology of the adverse effects of COX-inhibition.</description><identifier>ISSN: 1050-1738</identifier><identifier>EISSN: 1873-2615</identifier><identifier>DOI: 10.1016/j.tcm.2015.03.006</identifier><identifier>PMID: 25956433</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Acute coronary syndromes ; Adult ; Aged ; Anti-Inflammatory Agents, Non-Steroidal - adverse effects ; Anti-Inflammatory Agents, Non-Steroidal - therapeutic use ; Arthritis ; Aspirin ; Cardiovascular ; Cardiovascular disease ; Cardiovascular Diseases - enzymology ; Cardiovascular Diseases - etiology ; Cardiovascular Diseases - physiopathology ; Case-Control Studies ; Cell growth ; Cyclooxygenase 1 - drug effects ; Cyclooxygenase 1 - metabolism ; Cyclooxygenase 2 - drug effects ; Cyclooxygenase 2 - metabolism ; Cytokines ; Drug dosages ; Enzymes ; Female ; Follow-Up Studies ; Gene expression ; Growth factors ; Heart attacks ; Homeostasis ; Homeostasis - drug effects ; Humans ; Inflammation ; Lactones - adverse effects ; Lactones - therapeutic use ; Male ; Middle Aged ; Naproxen - adverse effects ; Naproxen - therapeutic use ; Patients ; Prevalence ; Randomized Controlled Trials as Topic ; Risk Assessment ; Rodents ; Smooth muscle ; Studies ; Sulfones - adverse effects ; Sulfones - therapeutic use ; Thrombosis</subject><ispartof>Trends in cardiovascular medicine, 2015-11, Vol.25 (8), p.726-735</ispartof><rights>Elsevier Inc.</rights><rights>2015 Elsevier Inc.</rights><rights>Copyright © 2015 Elsevier Inc. All rights reserved.</rights><rights>Copyright Elsevier Limited 2015</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c436t-33f0f1aedaba4c93ef2f5f91ed1221ae49a8fa91d0d07e64d9d1f1f539572ec23</citedby><cites>FETCH-LOGICAL-c436t-33f0f1aedaba4c93ef2f5f91ed1221ae49a8fa91d0d07e64d9d1f1f539572ec23</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.tcm.2015.03.006$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3548,27923,27924,45994</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25956433$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Anwar, Asif, MD</creatorcontrib><creatorcontrib>John Anwar, Imran, MS</creatorcontrib><creatorcontrib>Delafontaine, Patrice, MD</creatorcontrib><title>Elevation of cardiovascular risk by non-steroidal anti-inflammatory drugs</title><title>Trends in cardiovascular medicine</title><addtitle>Trends Cardiovasc Med</addtitle><description>Abstract Non-steroidal anti-inflammatory drugs (NSAIDs) are one of the most frequently used medications. NSAIDs profoundly modify prostaglandin homeostasis through inhibition of the enzyme, cyclooxygenase (COX), especially COX-2. COX-2 inhibition is associated with adverse cardiovascular outcomes as demonstrated by recent trials using this type of drug. This review explores the latest available data, including recent, randomized, clinical trials, controversies, and pathophysiology of the adverse effects of COX-inhibition.</description><subject>Acute coronary syndromes</subject><subject>Adult</subject><subject>Aged</subject><subject>Anti-Inflammatory Agents, Non-Steroidal - adverse effects</subject><subject>Anti-Inflammatory Agents, Non-Steroidal - therapeutic use</subject><subject>Arthritis</subject><subject>Aspirin</subject><subject>Cardiovascular</subject><subject>Cardiovascular disease</subject><subject>Cardiovascular Diseases - enzymology</subject><subject>Cardiovascular Diseases - etiology</subject><subject>Cardiovascular Diseases - physiopathology</subject><subject>Case-Control Studies</subject><subject>Cell growth</subject><subject>Cyclooxygenase 1 - drug effects</subject><subject>Cyclooxygenase 1 - metabolism</subject><subject>Cyclooxygenase 2 - drug effects</subject><subject>Cyclooxygenase 2 - metabolism</subject><subject>Cytokines</subject><subject>Drug dosages</subject><subject>Enzymes</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>Gene expression</subject><subject>Growth factors</subject><subject>Heart attacks</subject><subject>Homeostasis</subject><subject>Homeostasis - drug effects</subject><subject>Humans</subject><subject>Inflammation</subject><subject>Lactones - adverse effects</subject><subject>Lactones - therapeutic use</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Naproxen - adverse effects</subject><subject>Naproxen - therapeutic use</subject><subject>Patients</subject><subject>Prevalence</subject><subject>Randomized Controlled Trials as Topic</subject><subject>Risk Assessment</subject><subject>Rodents</subject><subject>Smooth muscle</subject><subject>Studies</subject><subject>Sulfones - adverse effects</subject><subject>Sulfones - therapeutic use</subject><subject>Thrombosis</subject><issn>1050-1738</issn><issn>1873-2615</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kcFqFTEUhoMotlYfwI0MuOlmxpxkkrmDIJRStVDooroOucmJ5DaT1GTmwn37ZrhVoQtXCeH7f3K-Q8h7oB1QkJ923WymjlEQHeUdpfIFOYXNwFsmQbysdypoCwPfnJA3pexoJXoJr8kJE6OQPeen5Poq4F7PPsUmucbobH3a62KWoHOTfblvtocmptiWGXPyVodGx9m3Prqgp0nPKR8am5df5S155XQo-O7pPCM_v179uPze3tx-u768uGlNz-Xccu6oA41Wb3VvRo6OOeFGQAuM1fd-1BunR7DU0gFlb0cLDpzgoxgYGsbPyPmx9yGn3wuWWU2-GAxBR0xLUTCwDRNSUFHRj8_QXVpyrL9bKTkIoAOtFBwpk1MpGZ16yH7S-aCAqtWz2qnqWa2eFeWqWqyZD0_Ny3ZC-zfxR2wFPh8BrCr2HrMqxmM0aH1GMyub_H_rvzxLm-CjNzrc4wHLvylUYYqqu3XR655B1B0PI_BHUAOiug</recordid><startdate>20151101</startdate><enddate>20151101</enddate><creator>Anwar, Asif, MD</creator><creator>John Anwar, Imran, MS</creator><creator>Delafontaine, Patrice, MD</creator><general>Elsevier Inc</general><general>Elsevier Limited</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7X8</scope></search><sort><creationdate>20151101</creationdate><title>Elevation of cardiovascular risk by non-steroidal anti-inflammatory drugs</title><author>Anwar, Asif, MD ; John Anwar, Imran, MS ; Delafontaine, Patrice, MD</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c436t-33f0f1aedaba4c93ef2f5f91ed1221ae49a8fa91d0d07e64d9d1f1f539572ec23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Acute coronary syndromes</topic><topic>Adult</topic><topic>Aged</topic><topic>Anti-Inflammatory Agents, Non-Steroidal - adverse effects</topic><topic>Anti-Inflammatory Agents, Non-Steroidal - therapeutic use</topic><topic>Arthritis</topic><topic>Aspirin</topic><topic>Cardiovascular</topic><topic>Cardiovascular disease</topic><topic>Cardiovascular Diseases - enzymology</topic><topic>Cardiovascular Diseases - etiology</topic><topic>Cardiovascular Diseases - physiopathology</topic><topic>Case-Control Studies</topic><topic>Cell growth</topic><topic>Cyclooxygenase 1 - drug effects</topic><topic>Cyclooxygenase 1 - metabolism</topic><topic>Cyclooxygenase 2 - drug effects</topic><topic>Cyclooxygenase 2 - metabolism</topic><topic>Cytokines</topic><topic>Drug dosages</topic><topic>Enzymes</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>Gene expression</topic><topic>Growth factors</topic><topic>Heart attacks</topic><topic>Homeostasis</topic><topic>Homeostasis - drug effects</topic><topic>Humans</topic><topic>Inflammation</topic><topic>Lactones - adverse effects</topic><topic>Lactones - therapeutic use</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Naproxen - adverse effects</topic><topic>Naproxen - therapeutic use</topic><topic>Patients</topic><topic>Prevalence</topic><topic>Randomized Controlled Trials as Topic</topic><topic>Risk Assessment</topic><topic>Rodents</topic><topic>Smooth muscle</topic><topic>Studies</topic><topic>Sulfones - adverse effects</topic><topic>Sulfones - therapeutic use</topic><topic>Thrombosis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Anwar, Asif, MD</creatorcontrib><creatorcontrib>John Anwar, Imran, MS</creatorcontrib><creatorcontrib>Delafontaine, Patrice, MD</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>MEDLINE - Academic</collection><jtitle>Trends in cardiovascular medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Anwar, Asif, MD</au><au>John Anwar, Imran, MS</au><au>Delafontaine, Patrice, MD</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Elevation of cardiovascular risk by non-steroidal anti-inflammatory drugs</atitle><jtitle>Trends in cardiovascular medicine</jtitle><addtitle>Trends Cardiovasc Med</addtitle><date>2015-11-01</date><risdate>2015</risdate><volume>25</volume><issue>8</issue><spage>726</spage><epage>735</epage><pages>726-735</pages><issn>1050-1738</issn><eissn>1873-2615</eissn><abstract>Abstract Non-steroidal anti-inflammatory drugs (NSAIDs) are one of the most frequently used medications. NSAIDs profoundly modify prostaglandin homeostasis through inhibition of the enzyme, cyclooxygenase (COX), especially COX-2. COX-2 inhibition is associated with adverse cardiovascular outcomes as demonstrated by recent trials using this type of drug. This review explores the latest available data, including recent, randomized, clinical trials, controversies, and pathophysiology of the adverse effects of COX-inhibition.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>25956433</pmid><doi>10.1016/j.tcm.2015.03.006</doi><tpages>10</tpages></addata></record> |
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| subjects | Acute coronary syndromes Adult Aged Anti-Inflammatory Agents, Non-Steroidal - adverse effects Anti-Inflammatory Agents, Non-Steroidal - therapeutic use Arthritis Aspirin Cardiovascular Cardiovascular disease Cardiovascular Diseases - enzymology Cardiovascular Diseases - etiology Cardiovascular Diseases - physiopathology Case-Control Studies Cell growth Cyclooxygenase 1 - drug effects Cyclooxygenase 1 - metabolism Cyclooxygenase 2 - drug effects Cyclooxygenase 2 - metabolism Cytokines Drug dosages Enzymes Female Follow-Up Studies Gene expression Growth factors Heart attacks Homeostasis Homeostasis - drug effects Humans Inflammation Lactones - adverse effects Lactones - therapeutic use Male Middle Aged Naproxen - adverse effects Naproxen - therapeutic use Patients Prevalence Randomized Controlled Trials as Topic Risk Assessment Rodents Smooth muscle Studies Sulfones - adverse effects Sulfones - therapeutic use Thrombosis |
| title | Elevation of cardiovascular risk by non-steroidal anti-inflammatory drugs |
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