Cytotoxicity assessment of three therapeutic agents, cyclosporin-A, cisplatin and doxorubicin, with the ciliated protozoan Tetrahymena pyriformis

Cyclosporin-A, a drug possessing potent immunosuppressive properties, is used to prevent allograft rejection. Cisplatin and doxorubicin are two of the pharmaceutical drugs most widely used in cancer chemotherapy. In this study, the cytotoxicological impact of these three therapeutic agents was deter...

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Veröffentlicht in:	Research in microbiology 2003-06, Vol.154 (5), p.375-385
Hauptverfasser:	Bonnet, Jean-Louis, Dusser, Martine, Bohatier, Jacques, Laffosse, Josée
Format:	Artikel
Sprache:	eng
Schlagworte:	Action of physical and chemical agents Animals Antineoplastic Agents - pharmacology Antineoplastic Agents - toxicity Biological and medical sciences Biological Assay Cisplatin Cisplatin - pharmacology Cisplatin - toxicity Cyclosporin-A Cyclosporine - pharmacology Cyclosporine - toxicity Cytotoxicity Dose-Response Relationship, Drug Doxorubicin Doxorubicin - pharmacology Doxorubicin - toxicity Drug Resistance Fundamental and applied biological sciences. Psychology Immunosuppressive Agents - pharmacology Immunosuppressive Agents - toxicity In vitro alternative test Medical sciences Microbiology Tetrahymena pyriformis Tetrahymena pyriformis - drug effects Tetrahymena pyriformis - growth & development Tetrahymena pyriformis - ultrastructure Tumors Virology
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