ICP0 and the U sub(S)3 protein kinase of herpes simplex virus 1 independently block histone deacetylation to enable gene expression

SK-N-SH cells exposed to low ratios of ICP0-null ( Delta ICP0) mutants of herpes simplex virus per cell express the viral alpha proteins, but the progression to beta and gamma gene expression does not ensue. In these restrictive cells, post- alpha gene expression can be induced after exposure of the...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2006-06, Vol.103 (26), p.9993-9998
Hauptverfasser:	Poon, Alice PW, Gu, Haidong, Roizman, Bernard
Format:	Artikel
Sprache:	eng
Schlagworte:	Baculovirus Cytomegalovirus Herpes simplex virus 1
Online-Zugang:	Volltext
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