Squamous/adenosquamous carcinoma of the gallbladder: Analysis of 34 cases and comparison of clinicopathologic features and surgical outcomes with adenocarcinoma
Objectives To explore clinicopathological features and effects of surgical treatment of squamous/adenosquamous carcinoma of the gallbladder. Methods We enrolled 411 patients who were surgically treated for gallbladder cancer in our hospital, including 10 with squamous cell carcinoma (SCC), 24 with a...
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| Veröffentlicht in: | Journal of surgical oncology 2015-11, Vol.112 (6), p.677-680 |
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| creator | Song, Hu-Wei Chen, Chen Shen, Hao-Xin Ma, Li Zhao, Ya-Ling Zhang, Guan-Jun Geng, Zhi-Min Wang, Lin |
| description | Objectives
To explore clinicopathological features and effects of surgical treatment of squamous/adenosquamous carcinoma of the gallbladder.
Methods
We enrolled 411 patients who were surgically treated for gallbladder cancer in our hospital, including 10 with squamous cell carcinoma (SCC), 24 with adenosquamous carcinoma (ASC), and 377 with adenocarcinoma (AC). The ASC–SCC group was compared with the AC group for clinicopathological features and surgical outcomes.
Results
The patients' average age was 61.4 years. Abdominal pain was the most common presenting symptom, and 67.6% of patients had gallstones. All patients had advanced‐stage (T3/T4) carcinomas. The ASC–SCC group had significantly higher percentages of T4 disease (61.8%) and N1 nodal involvement (58.8%) than did the AC group (T4 disease: 34.0%, P = 0.001; N1 involvement: 39.0%, P = 0.02). Patients in the ASC–SCC group who underwent R0 resections had significantly better 1‐year survival (30%) than those who underwent R1 or R2 resections (0%; P = 0.025), but lower 1‐year survival rates than similar‐staged patients in the AC group (69.3%; P = 0.016).
Conclusions
Patients with gallbladder ASC–SCC were similar to those with AC in clinical characteristics, but tended to have more infiltration of multiple adjacent organs and lymphatic metastasis. Curative resection could give these patients better outcomes. J. Surg. Oncol. 2015;112:677–680. © 2015 Wiley Periodicals, Inc. |
| doi_str_mv | 10.1002/jso.24065 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1727995674</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>3846876071</sourcerecordid><originalsourceid>FETCH-LOGICAL-c3915-d8e5ee24227bd0849b87d127abadaf970684a71f5edeb504a5775bc4207d71ea3</originalsourceid><addsrcrecordid>eNp1kc1u1DAUhSMEokNhwQsgS2xgkY7t2HHMripM-anaRUEsrRvb6Xhw4qmdqMzb8Kh4fjoLJFaW7_nuufY9RfGa4DOCMZ2vUjijDNf8STEjWNalxLJ5WsyyRksmJD4pXqS0whhLWbPnxQmtGW-YJLPiz-39BH2Y0hyMHUI63JCGqN0QekChQ-PSojvwvvVgjI0f0PkAfpNc2ooVy3CyCcFgkA79GqJLYdhK2rvB6bCGcRl8uHMadRbGKR7gNMVcA4_CNObGXH1w4xLtHnKc_7J41oFP9tXhPC1-LD59v_hcXt1cfrk4vyp1JQkvTWO5tZRRKlqD89_aRhhCBbRgoJMC1w0DQTpujW05ZsCF4K1mFAsjiIXqtHi3913HcD_ZNKreJW29h8HmhSgiqJCS14Jl9O0_6CpMMa9kR9VCVoLiTL3fUzqGlKLt1Dq6HuJGEay2sakcm9rFltk3B8ep7a05ko85ZWC-Bx6ct5v_O6mvtzePluW-w6XR_j52QPylalEJrn5eX6pvC1wtmo9MXVd_AUIvs9g</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1726793720</pqid></control><display><type>article</type><title>Squamous/adenosquamous carcinoma of the gallbladder: Analysis of 34 cases and comparison of clinicopathologic features and surgical outcomes with adenocarcinoma</title><source>Wiley Online Library - AutoHoldings Journals</source><source>MEDLINE</source><creator>Song, Hu-Wei ; Chen, Chen ; Shen, Hao-Xin ; Ma, Li ; Zhao, Ya-Ling ; Zhang, Guan-Jun ; Geng, Zhi-Min ; Wang, Lin</creator><creatorcontrib>Song, Hu-Wei ; Chen, Chen ; Shen, Hao-Xin ; Ma, Li ; Zhao, Ya-Ling ; Zhang, Guan-Jun ; Geng, Zhi-Min ; Wang, Lin</creatorcontrib><description>Objectives
To explore clinicopathological features and effects of surgical treatment of squamous/adenosquamous carcinoma of the gallbladder.
Methods
We enrolled 411 patients who were surgically treated for gallbladder cancer in our hospital, including 10 with squamous cell carcinoma (SCC), 24 with adenosquamous carcinoma (ASC), and 377 with adenocarcinoma (AC). The ASC–SCC group was compared with the AC group for clinicopathological features and surgical outcomes.
Results
The patients' average age was 61.4 years. Abdominal pain was the most common presenting symptom, and 67.6% of patients had gallstones. All patients had advanced‐stage (T3/T4) carcinomas. The ASC–SCC group had significantly higher percentages of T4 disease (61.8%) and N1 nodal involvement (58.8%) than did the AC group (T4 disease: 34.0%, P = 0.001; N1 involvement: 39.0%, P = 0.02). Patients in the ASC–SCC group who underwent R0 resections had significantly better 1‐year survival (30%) than those who underwent R1 or R2 resections (0%; P = 0.025), but lower 1‐year survival rates than similar‐staged patients in the AC group (69.3%; P = 0.016).
Conclusions
Patients with gallbladder ASC–SCC were similar to those with AC in clinical characteristics, but tended to have more infiltration of multiple adjacent organs and lymphatic metastasis. Curative resection could give these patients better outcomes. J. Surg. Oncol. 2015;112:677–680. © 2015 Wiley Periodicals, Inc.</description><identifier>ISSN: 0022-4790</identifier><identifier>EISSN: 1096-9098</identifier><identifier>DOI: 10.1002/jso.24065</identifier><identifier>PMID: 26458491</identifier><language>eng</language><publisher>United States: Blackwell Publishing Ltd</publisher><subject>Adenocarcinoma - mortality ; Adenocarcinoma - pathology ; Adenocarcinoma - surgery ; adenosquamous cell carcinoma ; Adult ; Aged ; Aged, 80 and over ; Carcinoma, Adenosquamous - mortality ; Carcinoma, Adenosquamous - pathology ; Carcinoma, Adenosquamous - surgery ; Carcinoma, Squamous Cell - mortality ; Carcinoma, Squamous Cell - pathology ; Carcinoma, Squamous Cell - surgery ; Female ; Follow-Up Studies ; gallbladder carcinoma ; Gallbladder Neoplasms - mortality ; Gallbladder Neoplasms - pathology ; Gallbladder Neoplasms - surgery ; Humans ; Male ; Middle Aged ; Neoplasm Staging ; Postoperative Complications ; Prognosis ; Retrospective Studies ; squamous cell carcinoma ; Survival Rate</subject><ispartof>Journal of surgical oncology, 2015-11, Vol.112 (6), p.677-680</ispartof><rights>2015 Wiley Periodicals, Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3915-d8e5ee24227bd0849b87d127abadaf970684a71f5edeb504a5775bc4207d71ea3</citedby><cites>FETCH-LOGICAL-c3915-d8e5ee24227bd0849b87d127abadaf970684a71f5edeb504a5775bc4207d71ea3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fjso.24065$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fjso.24065$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26458491$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Song, Hu-Wei</creatorcontrib><creatorcontrib>Chen, Chen</creatorcontrib><creatorcontrib>Shen, Hao-Xin</creatorcontrib><creatorcontrib>Ma, Li</creatorcontrib><creatorcontrib>Zhao, Ya-Ling</creatorcontrib><creatorcontrib>Zhang, Guan-Jun</creatorcontrib><creatorcontrib>Geng, Zhi-Min</creatorcontrib><creatorcontrib>Wang, Lin</creatorcontrib><title>Squamous/adenosquamous carcinoma of the gallbladder: Analysis of 34 cases and comparison of clinicopathologic features and surgical outcomes with adenocarcinoma</title><title>Journal of surgical oncology</title><addtitle>J. Surg. Oncol</addtitle><description>Objectives
To explore clinicopathological features and effects of surgical treatment of squamous/adenosquamous carcinoma of the gallbladder.
Methods
We enrolled 411 patients who were surgically treated for gallbladder cancer in our hospital, including 10 with squamous cell carcinoma (SCC), 24 with adenosquamous carcinoma (ASC), and 377 with adenocarcinoma (AC). The ASC–SCC group was compared with the AC group for clinicopathological features and surgical outcomes.
Results
The patients' average age was 61.4 years. Abdominal pain was the most common presenting symptom, and 67.6% of patients had gallstones. All patients had advanced‐stage (T3/T4) carcinomas. The ASC–SCC group had significantly higher percentages of T4 disease (61.8%) and N1 nodal involvement (58.8%) than did the AC group (T4 disease: 34.0%, P = 0.001; N1 involvement: 39.0%, P = 0.02). Patients in the ASC–SCC group who underwent R0 resections had significantly better 1‐year survival (30%) than those who underwent R1 or R2 resections (0%; P = 0.025), but lower 1‐year survival rates than similar‐staged patients in the AC group (69.3%; P = 0.016).
Conclusions
Patients with gallbladder ASC–SCC were similar to those with AC in clinical characteristics, but tended to have more infiltration of multiple adjacent organs and lymphatic metastasis. Curative resection could give these patients better outcomes. J. Surg. Oncol. 2015;112:677–680. © 2015 Wiley Periodicals, Inc.</description><subject>Adenocarcinoma - mortality</subject><subject>Adenocarcinoma - pathology</subject><subject>Adenocarcinoma - surgery</subject><subject>adenosquamous cell carcinoma</subject><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Carcinoma, Adenosquamous - mortality</subject><subject>Carcinoma, Adenosquamous - pathology</subject><subject>Carcinoma, Adenosquamous - surgery</subject><subject>Carcinoma, Squamous Cell - mortality</subject><subject>Carcinoma, Squamous Cell - pathology</subject><subject>Carcinoma, Squamous Cell - surgery</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>gallbladder carcinoma</subject><subject>Gallbladder Neoplasms - mortality</subject><subject>Gallbladder Neoplasms - pathology</subject><subject>Gallbladder Neoplasms - surgery</subject><subject>Humans</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Neoplasm Staging</subject><subject>Postoperative Complications</subject><subject>Prognosis</subject><subject>Retrospective Studies</subject><subject>squamous cell carcinoma</subject><subject>Survival Rate</subject><issn>0022-4790</issn><issn>1096-9098</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kc1u1DAUhSMEokNhwQsgS2xgkY7t2HHMripM-anaRUEsrRvb6Xhw4qmdqMzb8Kh4fjoLJFaW7_nuufY9RfGa4DOCMZ2vUjijDNf8STEjWNalxLJ5WsyyRksmJD4pXqS0whhLWbPnxQmtGW-YJLPiz-39BH2Y0hyMHUI63JCGqN0QekChQ-PSojvwvvVgjI0f0PkAfpNc2ooVy3CyCcFgkA79GqJLYdhK2rvB6bCGcRl8uHMadRbGKR7gNMVcA4_CNObGXH1w4xLtHnKc_7J41oFP9tXhPC1-LD59v_hcXt1cfrk4vyp1JQkvTWO5tZRRKlqD89_aRhhCBbRgoJMC1w0DQTpujW05ZsCF4K1mFAsjiIXqtHi3913HcD_ZNKreJW29h8HmhSgiqJCS14Jl9O0_6CpMMa9kR9VCVoLiTL3fUzqGlKLt1Dq6HuJGEay2sakcm9rFltk3B8ep7a05ko85ZWC-Bx6ct5v_O6mvtzePluW-w6XR_j52QPylalEJrn5eX6pvC1wtmo9MXVd_AUIvs9g</recordid><startdate>201511</startdate><enddate>201511</enddate><creator>Song, Hu-Wei</creator><creator>Chen, Chen</creator><creator>Shen, Hao-Xin</creator><creator>Ma, Li</creator><creator>Zhao, Ya-Ling</creator><creator>Zhang, Guan-Jun</creator><creator>Geng, Zhi-Min</creator><creator>Wang, Lin</creator><general>Blackwell Publishing Ltd</general><general>Wiley Subscription Services, Inc</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope><scope>7X8</scope></search><sort><creationdate>201511</creationdate><title>Squamous/adenosquamous carcinoma of the gallbladder: Analysis of 34 cases and comparison of clinicopathologic features and surgical outcomes with adenocarcinoma</title><author>Song, Hu-Wei ; Chen, Chen ; Shen, Hao-Xin ; Ma, Li ; Zhao, Ya-Ling ; Zhang, Guan-Jun ; Geng, Zhi-Min ; Wang, Lin</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3915-d8e5ee24227bd0849b87d127abadaf970684a71f5edeb504a5775bc4207d71ea3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Adenocarcinoma - mortality</topic><topic>Adenocarcinoma - pathology</topic><topic>Adenocarcinoma - surgery</topic><topic>adenosquamous cell carcinoma</topic><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Carcinoma, Adenosquamous - mortality</topic><topic>Carcinoma, Adenosquamous - pathology</topic><topic>Carcinoma, Adenosquamous - surgery</topic><topic>Carcinoma, Squamous Cell - mortality</topic><topic>Carcinoma, Squamous Cell - pathology</topic><topic>Carcinoma, Squamous Cell - surgery</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>gallbladder carcinoma</topic><topic>Gallbladder Neoplasms - mortality</topic><topic>Gallbladder Neoplasms - pathology</topic><topic>Gallbladder Neoplasms - surgery</topic><topic>Humans</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Neoplasm Staging</topic><topic>Postoperative Complications</topic><topic>Prognosis</topic><topic>Retrospective Studies</topic><topic>squamous cell carcinoma</topic><topic>Survival Rate</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Song, Hu-Wei</creatorcontrib><creatorcontrib>Chen, Chen</creatorcontrib><creatorcontrib>Shen, Hao-Xin</creatorcontrib><creatorcontrib>Ma, Li</creatorcontrib><creatorcontrib>Zhao, Ya-Ling</creatorcontrib><creatorcontrib>Zhang, Guan-Jun</creatorcontrib><creatorcontrib>Geng, Zhi-Min</creatorcontrib><creatorcontrib>Wang, Lin</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of surgical oncology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Song, Hu-Wei</au><au>Chen, Chen</au><au>Shen, Hao-Xin</au><au>Ma, Li</au><au>Zhao, Ya-Ling</au><au>Zhang, Guan-Jun</au><au>Geng, Zhi-Min</au><au>Wang, Lin</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Squamous/adenosquamous carcinoma of the gallbladder: Analysis of 34 cases and comparison of clinicopathologic features and surgical outcomes with adenocarcinoma</atitle><jtitle>Journal of surgical oncology</jtitle><addtitle>J. Surg. Oncol</addtitle><date>2015-11</date><risdate>2015</risdate><volume>112</volume><issue>6</issue><spage>677</spage><epage>680</epage><pages>677-680</pages><issn>0022-4790</issn><eissn>1096-9098</eissn><abstract>Objectives
To explore clinicopathological features and effects of surgical treatment of squamous/adenosquamous carcinoma of the gallbladder.
Methods
We enrolled 411 patients who were surgically treated for gallbladder cancer in our hospital, including 10 with squamous cell carcinoma (SCC), 24 with adenosquamous carcinoma (ASC), and 377 with adenocarcinoma (AC). The ASC–SCC group was compared with the AC group for clinicopathological features and surgical outcomes.
Results
The patients' average age was 61.4 years. Abdominal pain was the most common presenting symptom, and 67.6% of patients had gallstones. All patients had advanced‐stage (T3/T4) carcinomas. The ASC–SCC group had significantly higher percentages of T4 disease (61.8%) and N1 nodal involvement (58.8%) than did the AC group (T4 disease: 34.0%, P = 0.001; N1 involvement: 39.0%, P = 0.02). Patients in the ASC–SCC group who underwent R0 resections had significantly better 1‐year survival (30%) than those who underwent R1 or R2 resections (0%; P = 0.025), but lower 1‐year survival rates than similar‐staged patients in the AC group (69.3%; P = 0.016).
Conclusions
Patients with gallbladder ASC–SCC were similar to those with AC in clinical characteristics, but tended to have more infiltration of multiple adjacent organs and lymphatic metastasis. Curative resection could give these patients better outcomes. J. Surg. Oncol. 2015;112:677–680. © 2015 Wiley Periodicals, Inc.</abstract><cop>United States</cop><pub>Blackwell Publishing Ltd</pub><pmid>26458491</pmid><doi>10.1002/jso.24065</doi><tpages>4</tpages></addata></record> |
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| subjects | Adenocarcinoma - mortality Adenocarcinoma - pathology Adenocarcinoma - surgery adenosquamous cell carcinoma Adult Aged Aged, 80 and over Carcinoma, Adenosquamous - mortality Carcinoma, Adenosquamous - pathology Carcinoma, Adenosquamous - surgery Carcinoma, Squamous Cell - mortality Carcinoma, Squamous Cell - pathology Carcinoma, Squamous Cell - surgery Female Follow-Up Studies gallbladder carcinoma Gallbladder Neoplasms - mortality Gallbladder Neoplasms - pathology Gallbladder Neoplasms - surgery Humans Male Middle Aged Neoplasm Staging Postoperative Complications Prognosis Retrospective Studies squamous cell carcinoma Survival Rate |
| title | Squamous/adenosquamous carcinoma of the gallbladder: Analysis of 34 cases and comparison of clinicopathologic features and surgical outcomes with adenocarcinoma |
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