Membrane Composition Influences the Activity of in Vitro Refolded Human Vitamin K Epoxide Reductase

Human vitamin K epoxide reductase (hVKOR) is an integral membrane protein responsible for the maintenance of reduced vitamin K pools, a prerequisite for the action of γ-glutamyl carboxylase and hence for hemostasis. Here we describe the recombinant expression of hVKOR as an insoluble fusion protein...

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Veröffentlicht in:	Biochemistry (Easton) 2015-10, Vol.54 (42), p.6454-6461
Hauptverfasser:	Jaenecke, Frank, Friedrich-Epler, Beatrice, Parthier, Christoph, Stubbs, Milton T
Format:	Artikel
Sprache:	eng
Schlagworte:	Enzyme Inhibitors - pharmacology Humans In Vitro Techniques Kinetics Membrane Lipids - chemistry Membrane Lipids - metabolism Membrane Proteins - chemistry Membrane Proteins - genetics Membrane Proteins - metabolism Models, Molecular Phospholipids - chemistry Phospholipids - metabolism Protein Folding Recombinant Fusion Proteins - chemistry Recombinant Fusion Proteins - genetics Recombinant Fusion Proteins - metabolism Vitamin K Epoxide Reductases - chemistry Vitamin K Epoxide Reductases - genetics Vitamin K Epoxide Reductases - metabolism Warfarin - pharmacology
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