Maternal overt hypothyroidism and neurobehavioral outcome of neonates: A cohort study from an iodine-deficient area of Northern India
Objective To study the relation between maternal overt hypothyroidism and neurodevelopmental outcome of neonates in iodine-deficient region of Northern India (Kashmir Valley). Design Prospective cohort study. Setting Endocrinology department of a tertiary-care hospital. Participants 82 hypothyroid p...
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| Veröffentlicht in: | Indian pediatrics 2015-10, Vol.52 (10), p.864-866 |
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| creator | Ganaie, Mohammad Ashraf Charoo, Bashir A. Sofi, Riyaz Ahmad Ahmed, Asif Bhat, Javeed Iqbal |
| description | Objective
To study the relation between maternal overt hypothyroidism and neurodevelopmental outcome of neonates in iodine-deficient region of Northern India (Kashmir Valley).
Design
Prospective cohort study.
Setting
Endocrinology department of a tertiary-care hospital.
Participants
82 hypothyroid pregnant women were enrolled and followed up till delivery. The neonates born to this group represented the case neonates. 51 euthyroid healthy pregnant women were selected as control group. The neonates born to these mothers served as controls.
Main outcome measures
Early neonatal behavioral assessment at 3-4 weeks of age.
Results
The mean TSH and free T4 in neonates of mothers with well controlled hypothyroidism was significantly different from those born to mothers with poorly controlled hypothyroidism and controls in 1st trimester, but the difference was statistically insignificant for 2nd and 3rd trimester values.
Conclusion
Overt maternal hypothyroidism in iodine-deficient area constitutes a risk factor for an abnormal neurobehavioral development of affected child. |
| doi_str_mv | 10.1007/s13312-015-0733-8 |
| format | Article |
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To study the relation between maternal overt hypothyroidism and neurodevelopmental outcome of neonates in iodine-deficient region of Northern India (Kashmir Valley).
Design
Prospective cohort study.
Setting
Endocrinology department of a tertiary-care hospital.
Participants
82 hypothyroid pregnant women were enrolled and followed up till delivery. The neonates born to this group represented the case neonates. 51 euthyroid healthy pregnant women were selected as control group. The neonates born to these mothers served as controls.
Main outcome measures
Early neonatal behavioral assessment at 3-4 weeks of age.
Results
The mean TSH and free T4 in neonates of mothers with well controlled hypothyroidism was significantly different from those born to mothers with poorly controlled hypothyroidism and controls in 1st trimester, but the difference was statistically insignificant for 2nd and 3rd trimester values.
Conclusion
Overt maternal hypothyroidism in iodine-deficient area constitutes a risk factor for an abnormal neurobehavioral development of affected child.</description><identifier>ISSN: 0019-6061</identifier><identifier>EISSN: 0974-7559</identifier><identifier>DOI: 10.1007/s13312-015-0733-8</identifier><identifier>PMID: 26499010</identifier><language>eng</language><publisher>New Delhi: Springer India</publisher><subject>Adult ; Cohort Studies ; Cross-Sectional Studies ; Developing Countries ; Female ; Goiter, Endemic - diagnosis ; Goiter, Endemic - epidemiology ; Humans ; Hypothyroidism - diagnosis ; Hypothyroidism - epidemiology ; India ; Infant, Newborn ; Infant, Newborn, Diseases - diagnosis ; Infant, Newborn, Diseases - epidemiology ; Iodine - deficiency ; Maternal and Child Health ; Medicine ; Medicine & Public Health ; Neurodevelopmental Disorders - diagnosis ; Neurodevelopmental Disorders - epidemiology ; Pediatric Surgery ; Pediatrics ; Pregnancy ; Pregnancy Complications - diagnosis ; Pregnancy Complications - epidemiology ; Prospective Studies ; Reference Values ; Research Paper ; Thyroid Function Tests</subject><ispartof>Indian pediatrics, 2015-10, Vol.52 (10), p.864-866</ispartof><rights>Indian Academy of Pediatrics 2015</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c344t-205b111c84c1e46e9bfb54089880a249d7928e6ca2df852127fd7494d58032ae3</citedby><cites>FETCH-LOGICAL-c344t-205b111c84c1e46e9bfb54089880a249d7928e6ca2df852127fd7494d58032ae3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s13312-015-0733-8$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s13312-015-0733-8$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26499010$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ganaie, Mohammad Ashraf</creatorcontrib><creatorcontrib>Charoo, Bashir A.</creatorcontrib><creatorcontrib>Sofi, Riyaz Ahmad</creatorcontrib><creatorcontrib>Ahmed, Asif</creatorcontrib><creatorcontrib>Bhat, Javeed Iqbal</creatorcontrib><title>Maternal overt hypothyroidism and neurobehavioral outcome of neonates: A cohort study from an iodine-deficient area of Northern India</title><title>Indian pediatrics</title><addtitle>Indian Pediatr</addtitle><addtitle>Indian Pediatr</addtitle><description>Objective
To study the relation between maternal overt hypothyroidism and neurodevelopmental outcome of neonates in iodine-deficient region of Northern India (Kashmir Valley).
Design
Prospective cohort study.
Setting
Endocrinology department of a tertiary-care hospital.
Participants
82 hypothyroid pregnant women were enrolled and followed up till delivery. The neonates born to this group represented the case neonates. 51 euthyroid healthy pregnant women were selected as control group. The neonates born to these mothers served as controls.
Main outcome measures
Early neonatal behavioral assessment at 3-4 weeks of age.
Results
The mean TSH and free T4 in neonates of mothers with well controlled hypothyroidism was significantly different from those born to mothers with poorly controlled hypothyroidism and controls in 1st trimester, but the difference was statistically insignificant for 2nd and 3rd trimester values.
Conclusion
Overt maternal hypothyroidism in iodine-deficient area constitutes a risk factor for an abnormal neurobehavioral development of affected child.</description><subject>Adult</subject><subject>Cohort Studies</subject><subject>Cross-Sectional Studies</subject><subject>Developing Countries</subject><subject>Female</subject><subject>Goiter, Endemic - diagnosis</subject><subject>Goiter, Endemic - epidemiology</subject><subject>Humans</subject><subject>Hypothyroidism - diagnosis</subject><subject>Hypothyroidism - epidemiology</subject><subject>India</subject><subject>Infant, Newborn</subject><subject>Infant, Newborn, Diseases - diagnosis</subject><subject>Infant, Newborn, Diseases - epidemiology</subject><subject>Iodine - deficiency</subject><subject>Maternal and Child Health</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Neurodevelopmental Disorders - diagnosis</subject><subject>Neurodevelopmental Disorders - epidemiology</subject><subject>Pediatric Surgery</subject><subject>Pediatrics</subject><subject>Pregnancy</subject><subject>Pregnancy Complications - diagnosis</subject><subject>Pregnancy Complications - epidemiology</subject><subject>Prospective Studies</subject><subject>Reference Values</subject><subject>Research Paper</subject><subject>Thyroid Function Tests</subject><issn>0019-6061</issn><issn>0974-7559</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kM1u3SAQRlHUKv8PkE3EshtSwGAguyhK20hpu0nWCMM4Jro2N2BHug_Q9y7WTbrsapDmfN-Ig9AFo1eMUvW1sKZhnFAmCVVNQ_QBOqZGCaKkNJ_qmzJDWtqyI3RSygulvOGSHaIj3gpjKKPH6M9PN0Oe3AanN8gzHnbbNA-7nGKIZcRuCniCJacOBvcWU17BZfZpBJz6ukpTzZdrfIN9GlItKPMSdrjPaQ3jmEKcgAToo48wzdhlcGvyV2WHehjfTyG6M_S5d5sC5-_zFD19u3u8_UEefn-_v715IL4RYiacyo4x5rXwDEQLpus7Kag2WlPHhQnKcA2tdzz0WnLGVR-UMCJITRvuoDlFX_a925xeFyizHWPxsNm4-pOlWKa4MrqVqq0o26M-p1Iy9Hab4-jyzjJqV_t2b99W-3a1b3XNXL7XL90I4V_iQ3cF-B4odTU9Q7YvaVntl_-0_gUOh5FM</recordid><startdate>20151001</startdate><enddate>20151001</enddate><creator>Ganaie, Mohammad Ashraf</creator><creator>Charoo, Bashir A.</creator><creator>Sofi, Riyaz Ahmad</creator><creator>Ahmed, Asif</creator><creator>Bhat, Javeed Iqbal</creator><general>Springer India</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20151001</creationdate><title>Maternal overt hypothyroidism and neurobehavioral outcome of neonates: A cohort study from an iodine-deficient area of Northern India</title><author>Ganaie, Mohammad Ashraf ; Charoo, Bashir A. ; Sofi, Riyaz Ahmad ; Ahmed, Asif ; Bhat, Javeed Iqbal</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c344t-205b111c84c1e46e9bfb54089880a249d7928e6ca2df852127fd7494d58032ae3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Adult</topic><topic>Cohort Studies</topic><topic>Cross-Sectional Studies</topic><topic>Developing Countries</topic><topic>Female</topic><topic>Goiter, Endemic - diagnosis</topic><topic>Goiter, Endemic - epidemiology</topic><topic>Humans</topic><topic>Hypothyroidism - diagnosis</topic><topic>Hypothyroidism - epidemiology</topic><topic>India</topic><topic>Infant, Newborn</topic><topic>Infant, Newborn, Diseases - diagnosis</topic><topic>Infant, Newborn, Diseases - epidemiology</topic><topic>Iodine - deficiency</topic><topic>Maternal and Child Health</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Neurodevelopmental Disorders - diagnosis</topic><topic>Neurodevelopmental Disorders - epidemiology</topic><topic>Pediatric Surgery</topic><topic>Pediatrics</topic><topic>Pregnancy</topic><topic>Pregnancy Complications - diagnosis</topic><topic>Pregnancy Complications - epidemiology</topic><topic>Prospective Studies</topic><topic>Reference Values</topic><topic>Research Paper</topic><topic>Thyroid Function Tests</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ganaie, Mohammad Ashraf</creatorcontrib><creatorcontrib>Charoo, Bashir A.</creatorcontrib><creatorcontrib>Sofi, Riyaz Ahmad</creatorcontrib><creatorcontrib>Ahmed, Asif</creatorcontrib><creatorcontrib>Bhat, Javeed Iqbal</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Indian pediatrics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ganaie, Mohammad Ashraf</au><au>Charoo, Bashir A.</au><au>Sofi, Riyaz Ahmad</au><au>Ahmed, Asif</au><au>Bhat, Javeed Iqbal</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Maternal overt hypothyroidism and neurobehavioral outcome of neonates: A cohort study from an iodine-deficient area of Northern India</atitle><jtitle>Indian pediatrics</jtitle><stitle>Indian Pediatr</stitle><addtitle>Indian Pediatr</addtitle><date>2015-10-01</date><risdate>2015</risdate><volume>52</volume><issue>10</issue><spage>864</spage><epage>866</epage><pages>864-866</pages><issn>0019-6061</issn><eissn>0974-7559</eissn><abstract>Objective
To study the relation between maternal overt hypothyroidism and neurodevelopmental outcome of neonates in iodine-deficient region of Northern India (Kashmir Valley).
Design
Prospective cohort study.
Setting
Endocrinology department of a tertiary-care hospital.
Participants
82 hypothyroid pregnant women were enrolled and followed up till delivery. The neonates born to this group represented the case neonates. 51 euthyroid healthy pregnant women were selected as control group. The neonates born to these mothers served as controls.
Main outcome measures
Early neonatal behavioral assessment at 3-4 weeks of age.
Results
The mean TSH and free T4 in neonates of mothers with well controlled hypothyroidism was significantly different from those born to mothers with poorly controlled hypothyroidism and controls in 1st trimester, but the difference was statistically insignificant for 2nd and 3rd trimester values.
Conclusion
Overt maternal hypothyroidism in iodine-deficient area constitutes a risk factor for an abnormal neurobehavioral development of affected child.</abstract><cop>New Delhi</cop><pub>Springer India</pub><pmid>26499010</pmid><doi>10.1007/s13312-015-0733-8</doi><tpages>3</tpages></addata></record> |
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| ispartof | Indian pediatrics, 2015-10, Vol.52 (10), p.864-866 |
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| language | eng |
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| source | MEDLINE; Springer Nature - Complete Springer Journals; EZB-FREE-00999 freely available EZB journals; Alma/SFX Local Collection |
| subjects | Adult Cohort Studies Cross-Sectional Studies Developing Countries Female Goiter, Endemic - diagnosis Goiter, Endemic - epidemiology Humans Hypothyroidism - diagnosis Hypothyroidism - epidemiology India Infant, Newborn Infant, Newborn, Diseases - diagnosis Infant, Newborn, Diseases - epidemiology Iodine - deficiency Maternal and Child Health Medicine Medicine & Public Health Neurodevelopmental Disorders - diagnosis Neurodevelopmental Disorders - epidemiology Pediatric Surgery Pediatrics Pregnancy Pregnancy Complications - diagnosis Pregnancy Complications - epidemiology Prospective Studies Reference Values Research Paper Thyroid Function Tests |
| title | Maternal overt hypothyroidism and neurobehavioral outcome of neonates: A cohort study from an iodine-deficient area of Northern India |
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