Functionalized biocompatible WO3 nanoparticles for triggered and targeted in vitro and in vivo photothermal therapy
We report on dopamine-conjugated hyaluronic acid (HA-D), a mussel-inspired facile capping material that can modify tungsten oxide (WO3) nanoparticles to be both biocompatible and targetable, allowing precise delivery (WO3-HA) to a tumor site. Near-infrared (NIR) irradiated WO3-HA showed a rapid and...
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| Veröffentlicht in: | Journal of controlled release 2015-11, Vol.217, p.211-220 |
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| creator | Sharker, Shazid Md Kim, Sung Min Lee, Jung Eun Choi, Kyung Ho Shin, Gyojic Lee, Sangkug Lee, Kang Dae Jeong, Ji Hoon Lee, Haeshin Park, Sung Young |
| description | We report on dopamine-conjugated hyaluronic acid (HA-D), a mussel-inspired facile capping material that can modify tungsten oxide (WO3) nanoparticles to be both biocompatible and targetable, allowing precise delivery (WO3-HA) to a tumor site. Near-infrared (NIR) irradiated WO3-HA showed a rapid and substantial rise in photothermal heat to complete in vitro thermolysis of malignant MDAMB and A549 cancer cellsbut was found to be relatively less sensitive to normal MDCK cells. A long-term in vivo investigation of ~10nm HA thickness on WO3 (WO3-HA) nanoparticles demonstrated efficient photo-thermal conversion with time-dependent tumor target accumulation. This long-term in vivo survival study of WO3-HA showed promising biocompatibility, with a complete recovery from malignant tumor. Due to the importance of keeping simplicity in the design of therapeutic nanoparticles, we therefore expect that this facile scheme (HA-D) would contribute to the biocompatible development of versatile metallic nanoparticles for photothermal applications.
The ~10nm thickness of adhesive dopamine-conjugated hyaluronic acid (HA-D) on non-biocompatible WO3 nanoparticles demonstrated both biocompatible and targetable, allowing precise delivery (WO3-HA) to tumor site results promising hyperthermal therapy. [Display omitted] |
| doi_str_mv | 10.1016/j.jconrel.2015.09.010 |
| format | Article |
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The ~10nm thickness of adhesive dopamine-conjugated hyaluronic acid (HA-D) on non-biocompatible WO3 nanoparticles demonstrated both biocompatible and targetable, allowing precise delivery (WO3-HA) to tumor site results promising hyperthermal therapy. [Display omitted]</description><identifier>ISSN: 0168-3659</identifier><identifier>EISSN: 1873-4995</identifier><identifier>DOI: 10.1016/j.jconrel.2015.09.010</identifier><identifier>PMID: 26381897</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>Animals ; Biocompatibility ; Cell Line, Tumor ; Cell Survival ; Dogs ; Dopamine - administration & dosage ; Dopamine - chemistry ; Dopamine - therapeutic use ; Humans ; Hyaluronic acid ; Hyaluronic Acid - administration & dosage ; Hyaluronic Acid - chemistry ; Hyaluronic Acid - therapeutic use ; Light ; Madin Darby Canine Kidney Cells ; Metal Nanoparticles - administration & dosage ; Metal Nanoparticles - chemistry ; Metal Nanoparticles - therapeutic use ; Mice, Inbred BALB C ; Neoplasms - therapy ; Oxides - administration & dosage ; Oxides - chemistry ; Oxides - therapeutic use ; Phototherapy ; Photothermal therapy ; Target delivery ; Tungsten - administration & dosage ; Tungsten - chemistry ; Tungsten - therapeutic use ; WO3</subject><ispartof>Journal of controlled release, 2015-11, Vol.217, p.211-220</ispartof><rights>2015 Elsevier B.V.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c365t-6a839d29884bfd60daa096fe5d7c3a8c4df3e2f04b48ec00f26fd95d1691c103</citedby><cites>FETCH-LOGICAL-c365t-6a839d29884bfd60daa096fe5d7c3a8c4df3e2f04b48ec00f26fd95d1691c103</cites><orcidid>0000-0002-0358-6946</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0168365915301127$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26381897$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Sharker, Shazid Md</creatorcontrib><creatorcontrib>Kim, Sung Min</creatorcontrib><creatorcontrib>Lee, Jung Eun</creatorcontrib><creatorcontrib>Choi, Kyung Ho</creatorcontrib><creatorcontrib>Shin, Gyojic</creatorcontrib><creatorcontrib>Lee, Sangkug</creatorcontrib><creatorcontrib>Lee, Kang Dae</creatorcontrib><creatorcontrib>Jeong, Ji Hoon</creatorcontrib><creatorcontrib>Lee, Haeshin</creatorcontrib><creatorcontrib>Park, Sung Young</creatorcontrib><title>Functionalized biocompatible WO3 nanoparticles for triggered and targeted in vitro and in vivo photothermal therapy</title><title>Journal of controlled release</title><addtitle>J Control Release</addtitle><description>We report on dopamine-conjugated hyaluronic acid (HA-D), a mussel-inspired facile capping material that can modify tungsten oxide (WO3) nanoparticles to be both biocompatible and targetable, allowing precise delivery (WO3-HA) to a tumor site. Near-infrared (NIR) irradiated WO3-HA showed a rapid and substantial rise in photothermal heat to complete in vitro thermolysis of malignant MDAMB and A549 cancer cellsbut was found to be relatively less sensitive to normal MDCK cells. A long-term in vivo investigation of ~10nm HA thickness on WO3 (WO3-HA) nanoparticles demonstrated efficient photo-thermal conversion with time-dependent tumor target accumulation. This long-term in vivo survival study of WO3-HA showed promising biocompatibility, with a complete recovery from malignant tumor. Due to the importance of keeping simplicity in the design of therapeutic nanoparticles, we therefore expect that this facile scheme (HA-D) would contribute to the biocompatible development of versatile metallic nanoparticles for photothermal applications.
The ~10nm thickness of adhesive dopamine-conjugated hyaluronic acid (HA-D) on non-biocompatible WO3 nanoparticles demonstrated both biocompatible and targetable, allowing precise delivery (WO3-HA) to tumor site results promising hyperthermal therapy. [Display omitted]</description><subject>Animals</subject><subject>Biocompatibility</subject><subject>Cell Line, Tumor</subject><subject>Cell Survival</subject><subject>Dogs</subject><subject>Dopamine - administration & dosage</subject><subject>Dopamine - chemistry</subject><subject>Dopamine - therapeutic use</subject><subject>Humans</subject><subject>Hyaluronic acid</subject><subject>Hyaluronic Acid - administration & dosage</subject><subject>Hyaluronic Acid - chemistry</subject><subject>Hyaluronic Acid - therapeutic use</subject><subject>Light</subject><subject>Madin Darby Canine Kidney Cells</subject><subject>Metal Nanoparticles - administration & dosage</subject><subject>Metal Nanoparticles - chemistry</subject><subject>Metal Nanoparticles - therapeutic use</subject><subject>Mice, Inbred BALB C</subject><subject>Neoplasms - therapy</subject><subject>Oxides - administration & dosage</subject><subject>Oxides - chemistry</subject><subject>Oxides - therapeutic use</subject><subject>Phototherapy</subject><subject>Photothermal therapy</subject><subject>Target delivery</subject><subject>Tungsten - administration & dosage</subject><subject>Tungsten - chemistry</subject><subject>Tungsten - therapeutic use</subject><subject>WO3</subject><issn>0168-3659</issn><issn>1873-4995</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkE9v1DAQxS0EotvCRwDlyCVhHCeOfUKoooBUqZdKHC3HHm-9Suxge1cqn57sH7j2NHqj38ybeYR8oNBQoPzzrtmZGBJOTQu0b0A2QOEV2VAxsLqTsn9NNisnasZ7eUWuc94BQM-64S25ajkTVMhhQ_LdPpjiY9CT_4O2Gn00cV508eOE1a8HVgUd4qJT8WbCXLmYqpL8dotppXWwVdFpi2UVPlQHX1I8dU_iEKvlKZZYnjDNeqqOVS_P78gbp6eM7y_1hjzefXu8_VHfP3z_efv1vjbrzaXmWjBpWylENzrLwWoNkjvs7WCYFqazjmHroBs7gQbAtdxZ2VvKJTUU2A35dF67pPh7j7mo2WeD06QDxn1WdGgHKXreyRXtz6hJMeeETi3Jzzo9KwrqGLfaqUvc6hi3AqngZPHxYrEfZ7T_p_7luwJfzgCufx48JpWNx2DQ-oSmKBv9CxZ_Aebplqs</recordid><startdate>20151110</startdate><enddate>20151110</enddate><creator>Sharker, Shazid Md</creator><creator>Kim, Sung Min</creator><creator>Lee, Jung Eun</creator><creator>Choi, Kyung Ho</creator><creator>Shin, Gyojic</creator><creator>Lee, Sangkug</creator><creator>Lee, Kang Dae</creator><creator>Jeong, Ji Hoon</creator><creator>Lee, Haeshin</creator><creator>Park, Sung Young</creator><general>Elsevier B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-0358-6946</orcidid></search><sort><creationdate>20151110</creationdate><title>Functionalized biocompatible WO3 nanoparticles for triggered and targeted in vitro and in vivo photothermal therapy</title><author>Sharker, Shazid Md ; Kim, Sung Min ; Lee, Jung Eun ; Choi, Kyung Ho ; Shin, Gyojic ; Lee, Sangkug ; Lee, Kang Dae ; Jeong, Ji Hoon ; Lee, Haeshin ; Park, Sung Young</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c365t-6a839d29884bfd60daa096fe5d7c3a8c4df3e2f04b48ec00f26fd95d1691c103</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Animals</topic><topic>Biocompatibility</topic><topic>Cell Line, Tumor</topic><topic>Cell Survival</topic><topic>Dogs</topic><topic>Dopamine - administration & dosage</topic><topic>Dopamine - chemistry</topic><topic>Dopamine - therapeutic use</topic><topic>Humans</topic><topic>Hyaluronic acid</topic><topic>Hyaluronic Acid - administration & dosage</topic><topic>Hyaluronic Acid - chemistry</topic><topic>Hyaluronic Acid - therapeutic use</topic><topic>Light</topic><topic>Madin Darby Canine Kidney Cells</topic><topic>Metal Nanoparticles - administration & dosage</topic><topic>Metal Nanoparticles - chemistry</topic><topic>Metal Nanoparticles - therapeutic use</topic><topic>Mice, Inbred BALB C</topic><topic>Neoplasms - therapy</topic><topic>Oxides - administration & dosage</topic><topic>Oxides - chemistry</topic><topic>Oxides - therapeutic use</topic><topic>Phototherapy</topic><topic>Photothermal therapy</topic><topic>Target delivery</topic><topic>Tungsten - administration & dosage</topic><topic>Tungsten - chemistry</topic><topic>Tungsten - therapeutic use</topic><topic>WO3</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sharker, Shazid Md</creatorcontrib><creatorcontrib>Kim, Sung Min</creatorcontrib><creatorcontrib>Lee, Jung Eun</creatorcontrib><creatorcontrib>Choi, Kyung Ho</creatorcontrib><creatorcontrib>Shin, Gyojic</creatorcontrib><creatorcontrib>Lee, Sangkug</creatorcontrib><creatorcontrib>Lee, Kang Dae</creatorcontrib><creatorcontrib>Jeong, Ji Hoon</creatorcontrib><creatorcontrib>Lee, Haeshin</creatorcontrib><creatorcontrib>Park, Sung Young</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of controlled release</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sharker, Shazid Md</au><au>Kim, Sung Min</au><au>Lee, Jung Eun</au><au>Choi, Kyung Ho</au><au>Shin, Gyojic</au><au>Lee, Sangkug</au><au>Lee, Kang Dae</au><au>Jeong, Ji Hoon</au><au>Lee, Haeshin</au><au>Park, Sung Young</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Functionalized biocompatible WO3 nanoparticles for triggered and targeted in vitro and in vivo photothermal therapy</atitle><jtitle>Journal of controlled release</jtitle><addtitle>J Control Release</addtitle><date>2015-11-10</date><risdate>2015</risdate><volume>217</volume><spage>211</spage><epage>220</epage><pages>211-220</pages><issn>0168-3659</issn><eissn>1873-4995</eissn><abstract>We report on dopamine-conjugated hyaluronic acid (HA-D), a mussel-inspired facile capping material that can modify tungsten oxide (WO3) nanoparticles to be both biocompatible and targetable, allowing precise delivery (WO3-HA) to a tumor site. Near-infrared (NIR) irradiated WO3-HA showed a rapid and substantial rise in photothermal heat to complete in vitro thermolysis of malignant MDAMB and A549 cancer cellsbut was found to be relatively less sensitive to normal MDCK cells. A long-term in vivo investigation of ~10nm HA thickness on WO3 (WO3-HA) nanoparticles demonstrated efficient photo-thermal conversion with time-dependent tumor target accumulation. This long-term in vivo survival study of WO3-HA showed promising biocompatibility, with a complete recovery from malignant tumor. Due to the importance of keeping simplicity in the design of therapeutic nanoparticles, we therefore expect that this facile scheme (HA-D) would contribute to the biocompatible development of versatile metallic nanoparticles for photothermal applications.
The ~10nm thickness of adhesive dopamine-conjugated hyaluronic acid (HA-D) on non-biocompatible WO3 nanoparticles demonstrated both biocompatible and targetable, allowing precise delivery (WO3-HA) to tumor site results promising hyperthermal therapy. [Display omitted]</abstract><cop>Netherlands</cop><pub>Elsevier B.V</pub><pmid>26381897</pmid><doi>10.1016/j.jconrel.2015.09.010</doi><tpages>10</tpages><orcidid>https://orcid.org/0000-0002-0358-6946</orcidid></addata></record> |
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| identifier | ISSN: 0168-3659 |
| ispartof | Journal of controlled release, 2015-11, Vol.217, p.211-220 |
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| subjects | Animals Biocompatibility Cell Line, Tumor Cell Survival Dogs Dopamine - administration & dosage Dopamine - chemistry Dopamine - therapeutic use Humans Hyaluronic acid Hyaluronic Acid - administration & dosage Hyaluronic Acid - chemistry Hyaluronic Acid - therapeutic use Light Madin Darby Canine Kidney Cells Metal Nanoparticles - administration & dosage Metal Nanoparticles - chemistry Metal Nanoparticles - therapeutic use Mice, Inbred BALB C Neoplasms - therapy Oxides - administration & dosage Oxides - chemistry Oxides - therapeutic use Phototherapy Photothermal therapy Target delivery Tungsten - administration & dosage Tungsten - chemistry Tungsten - therapeutic use WO3 |
| title | Functionalized biocompatible WO3 nanoparticles for triggered and targeted in vitro and in vivo photothermal therapy |
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