Immediate Effects of Use of Recombinant Bone Morphogenetic Protein in Children Having Spinal Fusion and Refusion Procedures in United States

Immediate Effects of Use of Recombinant Bone Morphogenetic Protein in Children Having Spinal Fusion and Refusion Procedures in United States

STUDY DESIGN.Retrospective study of Nationwide Inpatient Sample (NIS). OBJECTIVE.The objective of this study is to estimate the prevalence of complications in children who had insertion of recombinant human bone morphogenetic protein (rhBMP) at the time of spinal fusion procedures (SFP) and to exami...

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Veröffentlicht in:Spine (Philadelphia, Pa. 1976) Pa. 1976), 2015-11, Vol.40 (21), p.1719-1726
Hauptverfasser: Allareddy, Veerasathpurush, Allareddy, Veerajalandhar, Martinez-Schlurmann, Natalia, Rampa, Sankeerth, Nalliah, R.P, Lidsky, K B, Rotta, A.T, Elangovan, Satheesh
Format: Artikel
Sprache:eng
Schlagworte:
Adolescent
Bone Morphogenetic Proteins - therapeutic use
Child
Child, Preschool
Female
Humans
Infant
Infant, Newborn
Male
Postoperative Complications - drug therapy
Postoperative Complications - epidemiology
Postoperative Complications - prevention & control
Recombinant Proteins - therapeutic use
Reoperation - methods
Reoperation - statistics & numerical data
Retrospective Studies
Spinal Fusion - methods
Spinal Fusion - statistics & numerical data
Treatment Outcome
United States
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Zusammenfassung:STUDY DESIGN.Retrospective study of Nationwide Inpatient Sample (NIS). OBJECTIVE.The objective of this study is to estimate the prevalence of complications in children who had insertion of recombinant human bone morphogenetic protein (rhBMP) at the time of spinal fusion procedures (SFP) and to examine if the use of rhBMP is associated with an increased risk of complications. SUMMARY OF BACKGROUND DATA.Use of rhBMP for SFP has been associated with conflicting safety profile reports in adults. METHODS.NIS (years 2004–2010) was used. All patients with age  
ISSN:0362-2436
1528-1159
DOI:10.1097/BRS.0000000000001110