Kaempferol Inhibits IL-4-Induced STAT6 Activation by Specifically Targeting JAK3

IL-4 is involved in several human diseases including allergies, autoimmunity, and cancer. Its effects are mainly mediated through the transcription factor STAT6. Therefore, investigation of compounds that regulate STAT6 activation is of great interest for these diseases. Natural polyphenols are comp...

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Veröffentlicht in:	Journal of Immunology 2007-09, Vol.179 (6), p.3881-3887
Hauptverfasser:	Cortes, Jose R, Perez-G, Moises, Rivas, Maria D, Zamorano, Jose
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cell Line, Tumor Dose-Response Relationship, Drug Drug Delivery Systems HL-60 Cells Humans Interleukin-4 - antagonists & inhibitors Interleukin-4 - physiology Janus Kinase 1 - metabolism Janus Kinase 3 - antagonists & inhibitors Janus Kinase 3 - biosynthesis Janus Kinase 3 - deficiency Janus Kinase 3 - genetics Kaempferols - pharmacology Kaempferols - toxicity Lymphocyte Culture Test, Mixed Mice Mice, Inbred BALB C Phosphorylation - drug effects Protein Kinase Inhibitors - pharmacology Protein Kinase Inhibitors - toxicity STAT6 Transcription Factor - antagonists & inhibitors STAT6 Transcription Factor - metabolism U937 Cells
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