Characterization of a conserved aphidicolin-sensitive common fragile site at human 4q22 and mouse 6C1: possible association with an inherited disease and cancer

Fragile sites are classified as common or rare depending on their occurrence in the populations. While rare sites are mainly associated with inherited diseases, common sites have been involved in somatic rearrangements found in the chromosomes of cancer cells. Here we study a mouse locus containing...

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Veröffentlicht in:	Oncogene 2004-09, Vol.23 (41), p.6872-6880
Hauptverfasser:	Rozier, Lorène, El-Achkar, Eliane, Apiou, Françoise, Debatisse, Michelle
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Aphidicolin Aphidicolin - pharmacology Apoptosis Biological and medical sciences Carcinogenesis Cell Biology Cell physiology Cell transformation and carcinogenesis. Action of oncogenes and antioncogenes Chromosome Aberrations Chromosome Fragile Sites Chromosome fragility (bloom syndrome, ataxia telangiectasia, fanconi anemia, x-linked mental retardation...) Chromosome Mapping Chromosome rearrangements Chromosomes Chromosomes, Human, Pair 4 Conserved Sequence Disease Fragile sites Fundamental and applied biological sciences. Psychology Genetic Diseases, Inborn - genetics Genomes Glutamic acid receptors (ionotropic) Hepatocellular carcinoma Hereditary diseases Human Genetics Humans In Situ Hybridization, Fluorescence Inbreeding Internal Medicine Liver cancer Liver Neoplasms - genetics Loss of Heterozygosity Medical genetics Medical sciences Medicine Medicine & Public Health Mice Molecular and cellular biology Oncology original-paper Receptors, Glutamate - genetics Synteny
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