Oncogene regulation of tumor suppressor genes in tumorigenesis

We attempted to demonstrate whether there is an epigenetic link between oncogenes and tumor suppression genes in tumorigenesis. We designed a high throughput model to identify a candidate group of tumor suppressor genes potentially regulated by oncogenes. Gene expression profiling of mock-transfecte...

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Veröffentlicht in:	Carcinogenesis (New York) 2005-02, Vol.26 (2), p.487-494
Hauptverfasser:	Sung, Jimmy, Turner, Joel, McCarthy, Susan, Enkemann, Steve, Li, Chan Gong, Yan, Perally, Huang, Timothy, Yeatman, Timothy J.
Format:	Artikel
Sprache:	eng
Schlagworte:	5-aza-2′-deoxycytidine Animals Azacitidine - analogs & derivatives Azacitidine - pharmacology Biological and medical sciences Carcinogenesis, carcinogens and anticarcinogens Cells, Cultured DAC DNA Methylation - drug effects DNA Modification Methylases - metabolism DNA-cytosine 5-methyltransferase DNMT1 Fibroblasts - metabolism Gene Expression Regulation, Neoplastic - drug effects Gene Expression Regulation, Neoplastic - physiology Genes, src - genetics Genes, Tumor Suppressor Medical sciences Microarray Analysis - methods Oncogenes Promoter Regions, Genetic - genetics Rats Tumors
Online-Zugang:	Volltext
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