Polymorphism in apoptotic BAX (-248G>A) gene but not in anti-apoptotic BCL2 (-938C>A) gene and its protein and mRNA expression are associated with cervical intraepithelial neoplasia

HPV is associated with cervical cancer and plays a crucial role in tumor formation. Apoptosis is regulated by different pathways involving genes that either promote (BCL2 gene) or inhibit (BAX gene) cell death. Our goal was to determine whether the BCL2 - 938C>A (rs2279115) and BAX - 248G>A (r...

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Veröffentlicht in:	Apoptosis (London) 2015-10, Vol.20 (10), p.1347-1357
Hauptverfasser:	Fernandes, Ana Teresa G., Rocha, Natália P., Vendrame, Elena, Russomano, Fabio, Grinsztejn, Beatriz J., Friedman, Ruth K., Pinto, Amanda C., Klumb, Evandro M., Avvad, Elyzabeth, Macedo, Jacyara, Martínez-Maza, Otoniel, Bonecini-Almeida, Maria da Gloria
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Apoptosis bcl-2-Associated X Protein - genetics bcl-2-Associated X Protein - metabolism Biochemistry Biomedical and Life Sciences Biomedicine Cancer Research Carcinogenesis Carcinoma, Squamous Cell - genetics Carcinoma, Squamous Cell - metabolism Case-Control Studies Cell Biology Cervical Intraepithelial Neoplasia - genetics Cervical Intraepithelial Neoplasia - metabolism Female Genotype Human papillomavirus Humans Middle Aged Oncology Original Paper Papillomaviridae - metabolism Polymorphism, Single Nucleotide Proto-Oncogene Proteins c-bcl-2 - genetics Proto-Oncogene Proteins c-bcl-2 - metabolism RNA, Messenger - genetics RNA, Messenger - metabolism Uterine Cervical Neoplasms - genetics Uterine Cervical Neoplasms - metabolism Virology
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